ENSG00000165609

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000491614 ENSG00000165609 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDT5 protein_coding protein_coding 92.02706 92.48018 98.73938 12.09816 0.5527089 0.09447138 15.20361 12.23222 20.72376 0.8131575 1.1958522 0.7601164 0.1637125 0.1344333 0.2098 0.07536667 1.656943e-03 5.889127e-15 FALSE TRUE
ENST00000537776 ENSG00000165609 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDT5 protein_coding protein_coding 92.02706 92.48018 98.73938 12.09816 0.5527089 0.09447138 63.42039 70.87701 62.56532 9.6201648 0.3990644 -0.1799276 0.6885542 0.7655333 0.6337 -0.13183333 5.889127e-15 5.889127e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165609 E001 384.659542 0.0028449489 1.017682e-02 2.920057e-02 10 12165330 12166088 759 - 2.638 2.537 -0.335
ENSG00000165609 E002 256.294381 0.0072015218 2.309894e-03 8.182087e-03 10 12166089 12166508 420 - 2.495 2.327 -0.560
ENSG00000165609 E003 170.228200 0.0004460457 9.965315e-10 1.478386e-08 10 12166509 12166743 235 - 2.330 2.148 -0.609
ENSG00000165609 E004 356.701197 0.0031222048 5.315869e-20 3.372657e-18 10 12166744 12167543 800 - 2.706 2.384 -1.074
ENSG00000165609 E005 53.525940 0.0006459193 2.544856e-17 1.176752e-15 10 12167544 12167544 1 - 1.930 1.501 -1.455
ENSG00000165609 E006 100.542532 0.0079889339 2.420201e-09 3.340131e-08 10 12167545 12167575 31 - 2.173 1.821 -1.181
ENSG00000165609 E007 79.835892 0.0069725861 1.178836e-09 1.722935e-08 10 12167576 12167576 1 - 2.078 1.719 -1.209
ENSG00000165609 E008 189.054137 0.0016151152 1.197270e-08 1.455088e-07 10 12167577 12167656 80 - 2.381 2.187 -0.648
ENSG00000165609 E009 163.815899 0.0002604950 1.417336e-05 9.089405e-05 10 12167657 12167659 3 - 2.290 2.161 -0.433
ENSG00000165609 E010 180.796568 0.0002170066 5.844859e-03 1.820424e-02 10 12167660 12167661 2 - 2.308 2.227 -0.271
ENSG00000165609 E011 283.350125 0.0013677108 6.157071e-01 7.339185e-01 10 12167662 12167671 10 - 2.453 2.458 0.016
ENSG00000165609 E012 539.682744 0.0010922435 9.748575e-06 6.499290e-05 10 12167672 12167737 66 - 2.682 2.769 0.287
ENSG00000165609 E013 634.747456 0.0002430648 9.684452e-19 5.364592e-17 10 12167738 12167811 74 - 2.728 2.857 0.429
ENSG00000165609 E014 30.060657 0.0108991670 1.575503e-06 1.253251e-05 10 12169722 12170156 435 - 1.674 1.261 -1.422
ENSG00000165609 E015 7.273965 0.1039203798 4.912233e-02 1.075897e-01 10 12170232 12170257 26 - 1.080 0.708 -1.427
ENSG00000165609 E016 18.886664 0.0009681741 1.079903e-05 7.119696e-05 10 12170258 12170470 213 - 1.467 1.113 -1.240
ENSG00000165609 E017 18.556804 0.0010398482 7.164669e-05 3.881509e-04 10 12170471 12170716 246 - 1.446 1.123 -1.131
ENSG00000165609 E018 516.458649 0.0008379654 6.325537e-14 1.848456e-12 10 12170717 12170768 52 - 2.626 2.772 0.487
ENSG00000165609 E019 302.669630 0.0019156212 1.579710e-05 1.002887e-04 10 12170769 12170770 2 - 2.412 2.531 0.397
ENSG00000165609 E020 18.069029 0.0010369720 8.748189e-02 1.713185e-01 10 12170771 12170899 129 - 1.363 1.221 -0.496
ENSG00000165609 E021 388.872188 0.0012687524 1.917563e-04 9.285738e-04 10 12170900 12170908 9 - 2.543 2.627 0.279
ENSG00000165609 E022 16.807795 0.0012102504 8.815427e-02 1.723127e-01 10 12170909 12170912 4 - 1.180 1.314 0.473
ENSG00000165609 E023 10.072948 0.0110302307 3.938786e-05 2.274141e-04 10 12172490 12172764 275 - 1.261 0.791 -1.733
ENSG00000165609 E024 434.279562 0.0008534446 2.409015e-03 8.488906e-03 10 12172765 12172768 4 - 2.607 2.665 0.191
ENSG00000165609 E025 751.908009 0.0007535396 4.732905e-07 4.205604e-06 10 12172769 12172866 98 - 2.830 2.910 0.265
ENSG00000165609 E026 695.673021 0.0001392190 1.274711e-05 8.264834e-05 10 12173718 12173813 96 - 2.815 2.867 0.174
ENSG00000165609 E027 557.342684 0.0002383037 4.747406e-04 2.063322e-03 10 12177793 12177842 50 - 2.721 2.769 0.158
ENSG00000165609 E028 522.549214 0.0001256317 3.892208e-03 1.284187e-02 10 12177843 12177900 58 - 2.700 2.737 0.123
ENSG00000165609 E029 3.019551 0.0064445833 8.517281e-01 9.080629e-01 10 12179029 12179082 54 - 0.613 0.576 -0.166
ENSG00000165609 E030 656.798904 0.0001096087 1.946284e-01 3.195348e-01 10 12179083 12179132 50 - 2.815 2.824 0.030
ENSG00000165609 E031 4.814229 0.0605597086 1.958366e-02 5.059341e-02 10 12180395 12180489 95 - 0.951 0.569 -1.551
ENSG00000165609 E032 3.790267 0.0047187069 4.268793e-02 9.597337e-02 10 12184494 12184532 39 - 0.836 0.538 -1.256
ENSG00000165609 E033 797.309716 0.0006102462 3.312618e-01 4.748650e-01 10 12184889 12184956 68 - 2.919 2.887 -0.104
ENSG00000165609 E034 914.115935 0.0010258625 3.469294e-02 8.106105e-02 10 12186229 12186332 104 - 2.991 2.934 -0.191
ENSG00000165609 E035 3.165669 0.0050509215 5.140225e-01 6.487791e-01 10 12192378 12192440 63 - 0.681 0.575 -0.457
ENSG00000165609 E036 6.332390 0.0498273215 4.054915e-01 5.491723e-01 10 12195687 12195769 83 - 0.791 0.907 0.449
ENSG00000165609 E037 734.775438 0.0040495622 6.927212e-02 1.421526e-01 10 12195770 12196144 375 - 2.909 2.825 -0.280