ENSG00000165458

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298229 ENSG00000165458 HEK293_OSMI2_2hA HEK293_TMG_2hB INPPL1 protein_coding protein_coding 53.58138 70.35906 37.24241 5.456736 0.4779524 -0.9176073 4.152030 10.8032944 2.624566 1.8408945 1.3140962 -2.0371687 0.06510833 0.151500000 0.07010000 -0.08140000 6.510571e-01 7.93531e-38 FALSE TRUE
ENST00000537656 ENSG00000165458 HEK293_OSMI2_2hA HEK293_TMG_2hB INPPL1 protein_coding protein_coding 53.58138 70.35906 37.24241 5.456736 0.4779524 -0.9176073 1.990460 0.5706576 2.466084 0.1336643 0.5159132 2.0923004 0.04225417 0.008166667 0.06656667 0.05840000 3.005438e-06 7.93531e-38   FALSE
ENST00000538751 ENSG00000165458 HEK293_OSMI2_2hA HEK293_TMG_2hB INPPL1 protein_coding protein_coding 53.58138 70.35906 37.24241 5.456736 0.4779524 -0.9176073 4.574904 4.2310010 1.792808 1.9554212 0.5813886 -1.2341595 0.09166250 0.060366667 0.04790000 -0.01246667 1.000000e+00 7.93531e-38 FALSE TRUE
ENST00000541303 ENSG00000165458 HEK293_OSMI2_2hA HEK293_TMG_2hB INPPL1 protein_coding retained_intron 53.58138 70.35906 37.24241 5.456736 0.4779524 -0.9176073 2.439339 1.3318397 3.139099 0.6154946 0.6042714 1.2307268 0.04929167 0.018100000 0.08440000 0.06630000 1.373895e-02 7.93531e-38 FALSE TRUE
ENST00000541752 ENSG00000165458 HEK293_OSMI2_2hA HEK293_TMG_2hB INPPL1 protein_coding protein_coding 53.58138 70.35906 37.24241 5.456736 0.4779524 -0.9176073 7.947107 20.0857464 0.000000 2.7571347 0.0000000 -10.9726745 0.12128750 0.285700000 0.00000000 -0.28570000 7.935310e-38 7.93531e-38 FALSE FALSE
ENST00000545355 ENSG00000165458 HEK293_OSMI2_2hA HEK293_TMG_2hB INPPL1 protein_coding retained_intron 53.58138 70.35906 37.24241 5.456736 0.4779524 -0.9176073 7.252936 4.8388645 6.635649 0.9404803 0.1991802 0.4547632 0.14379583 0.067700000 0.17830000 0.11060000 1.370783e-08 7.93531e-38 FALSE TRUE
MSTRG.5911.13 ENSG00000165458 HEK293_OSMI2_2hA HEK293_TMG_2hB INPPL1 protein_coding   53.58138 70.35906 37.24241 5.456736 0.4779524 -0.9176073 8.239266 15.1885749 5.073555 1.8267675 0.5181206 -1.5800265 0.14782083 0.219200000 0.13640000 -0.08280000 1.740583e-01 7.93531e-38 FALSE TRUE
MSTRG.5911.4 ENSG00000165458 HEK293_OSMI2_2hA HEK293_TMG_2hB INPPL1 protein_coding   53.58138 70.35906 37.24241 5.456736 0.4779524 -0.9176073 5.868982 6.0707281 4.715821 1.6569822 0.7744883 -0.3636792 0.10917917 0.085766667 0.12700000 0.04123333 5.379444e-01 7.93531e-38 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165458 E001 1.7275716 0.0218042912 6.256713e-02 1.309727e-01 11 72223685 72223700 16 + 0.587 0.277 -1.683
ENSG00000165458 E002 3.8666376 0.0040648419 3.265038e-02 7.710115e-02 11 72223701 72223803 103 + 0.828 0.537 -1.230
ENSG00000165458 E003 1.4027985 0.0101563390 3.878808e-03 1.280323e-02 11 72223871 72223890 20 + 0.638 0.159 -2.913
ENSG00000165458 E004 15.3261298 0.0235230009 6.300346e-02 1.317114e-01 11 72223891 72223943 53 + 1.282 1.104 -0.633
ENSG00000165458 E005 16.7558819 0.0194092039 3.054645e-02 7.304245e-02 11 72223944 72223960 17 + 1.333 1.132 -0.707
ENSG00000165458 E006 4.9986825 0.0036318860 6.681402e-02 1.380867e-01 11 72223961 72224114 154 + 0.886 0.658 -0.912
ENSG00000165458 E007 0.8115992 0.0159648674 1.778733e-01 2.984700e-01 11 72224115 72224119 5 + 0.386 0.159 -1.691
ENSG00000165458 E008 2.6960098 0.1014851536 9.337004e-02 1.803887e-01 11 72224120 72224146 27 + 0.724 0.411 -1.447
ENSG00000165458 E009 9.5231372 0.0023172075 6.769085e-02 1.395168e-01 11 72224147 72224184 38 + 1.095 0.920 -0.646
ENSG00000165458 E010 2.1294891 0.1171211866 1.649602e-01 2.816464e-01 11 72224185 72224205 21 + 0.638 0.369 -1.319
ENSG00000165458 E011 2.1734938 0.0073129924 6.800942e-01 7.840669e-01 11 72224767 72224779 13 + 0.386 0.477 0.481
ENSG00000165458 E012 69.9342489 0.0233417996 3.800660e-03 1.258299e-02 11 72224780 72225068 289 + 1.941 1.732 -0.705
ENSG00000165458 E013 63.1704177 0.0058664009 5.716270e-04 2.427713e-03 11 72225069 72225166 98 + 1.875 1.702 -0.585
ENSG00000165458 E014 6.5173464 0.0055327788 1.501178e-06 1.200480e-05 11 72227881 72228189 309 + 1.157 0.589 -2.212
ENSG00000165458 E015 87.0404021 0.0118931462 1.151332e-02 3.238022e-02 11 72228190 72228253 64 + 1.988 1.853 -0.456
ENSG00000165458 E016 146.9713486 0.0002621515 1.134927e-03 4.420861e-03 11 72228348 72228467 120 + 2.170 2.093 -0.257
ENSG00000165458 E017 114.8083871 0.0006094060 3.550054e-03 1.186904e-02 11 72228468 72228498 31 + 2.065 1.984 -0.270
ENSG00000165458 E018 16.1924455 0.0011245628 7.825640e-11 1.405788e-09 11 72228499 72228715 217 + 1.492 0.975 -1.835
ENSG00000165458 E019 176.0777382 0.0010986624 3.821945e-02 8.776436e-02 11 72228727 72228847 121 + 2.223 2.183 -0.133
ENSG00000165458 E020 11.8606492 0.0014640136 7.160402e-17 3.137906e-15 11 72228849 72229007 159 + 1.465 0.679 -2.901
ENSG00000165458 E021 15.7854154 0.0076589557 3.118117e-05 1.847957e-04 11 72229008 72229089 82 + 1.404 1.042 -1.283
ENSG00000165458 E022 215.9966603 0.0013187551 2.987967e-04 1.374770e-03 11 72229090 72229230 141 + 2.342 2.259 -0.276
ENSG00000165458 E023 207.3695909 0.0019831679 2.345208e-04 1.110691e-03 11 72229465 72229558 94 + 2.333 2.239 -0.316
ENSG00000165458 E024 193.6978527 0.0067222874 1.884451e-03 6.866246e-03 11 72229663 72229752 90 + 2.322 2.203 -0.397
ENSG00000165458 E025 211.8108686 0.0015664349 2.618986e-02 6.433430e-02 11 72229924 72230019 96 + 2.305 2.263 -0.142
ENSG00000165458 E026 3.0895084 0.0394212969 6.803585e-02 1.401075e-01 11 72230101 72230120 20 + 0.762 0.477 -1.257
ENSG00000165458 E027 259.9047528 0.0002002365 3.505311e-02 8.175190e-02 11 72230121 72230271 151 + 2.381 2.357 -0.083
ENSG00000165458 E028 243.3345303 0.0006163151 1.375995e-03 5.228203e-03 11 72230362 72230468 107 + 2.379 2.320 -0.195
ENSG00000165458 E029 2.3742304 0.0136349610 2.186490e-02 5.539752e-02 11 72230718 72230795 78 + 0.724 0.367 -1.693
ENSG00000165458 E030 284.0207580 0.0001511585 6.837295e-06 4.720155e-05 11 72230796 72230898 103 + 2.456 2.380 -0.254
ENSG00000165458 E031 341.8048012 0.0001777298 6.406915e-03 1.967947e-02 11 72230993 72231141 149 + 2.505 2.474 -0.104
ENSG00000165458 E032 224.2580970 0.0002286653 1.426975e-01 2.516956e-01 11 72231142 72231189 48 + 2.306 2.294 -0.040
ENSG00000165458 E033 6.5062253 0.0026054038 4.131936e-07 3.716036e-06 11 72231190 72231249 60 + 1.172 0.589 -2.264
ENSG00000165458 E034 12.6322008 0.0013435175 1.931344e-11 3.837711e-10 11 72231250 72231497 248 + 1.428 0.830 -2.161
ENSG00000165458 E035 325.2585127 0.0003602048 2.467792e-02 6.122041e-02 11 72231498 72231615 118 + 2.477 2.453 -0.080
ENSG00000165458 E036 263.6668633 0.0002032392 3.566524e-04 1.605902e-03 11 72232240 72232307 68 + 2.412 2.353 -0.197
ENSG00000165458 E037 207.9833596 0.0001750615 9.461808e-07 7.888185e-06 11 72232308 72232336 29 + 2.339 2.236 -0.344
ENSG00000165458 E038 18.0619400 0.0432938650 9.591531e-10 1.427181e-08 11 72232337 72232625 289 + 1.624 0.864 -2.705
ENSG00000165458 E039 349.2001971 0.0001658707 9.961680e-05 5.200646e-04 11 72232626 72232764 139 + 2.530 2.476 -0.182
ENSG00000165458 E040 0.5890081 0.0362705852 4.228405e-01 5.659832e-01 11 72232871 72232874 4 + 0.291 0.159 -1.112
ENSG00000165458 E041 289.5445906 0.0003246542 2.623386e-03 9.138076e-03 11 72232875 72232974 100 + 2.442 2.398 -0.147
ENSG00000165458 E042 329.4302908 0.0001668160 7.494187e-04 3.076651e-03 11 72233075 72233163 89 + 2.497 2.451 -0.153
ENSG00000165458 E043 336.9387188 0.0001919118 3.099696e-02 7.391258e-02 11 72233441 72233522 82 + 2.489 2.469 -0.066
ENSG00000165458 E044 44.9674060 0.0007697787 6.172007e-30 1.034751e-27 11 72233523 72233654 132 + 1.939 1.361 -1.967
ENSG00000165458 E045 229.6476772 0.0001902838 5.678019e-01 6.945579e-01 11 72233655 72233679 25 + 2.300 2.312 0.039
ENSG00000165458 E046 338.3096306 0.0001568753 3.324100e-02 7.827631e-02 11 72233680 72233744 65 + 2.491 2.472 -0.063
ENSG00000165458 E047 431.1257211 0.0001398590 2.887551e-03 9.933321e-03 11 72234281 72234394 114 + 2.604 2.574 -0.098
ENSG00000165458 E048 358.7640283 0.0010529877 6.189029e-02 1.297982e-01 11 72234527 72234615 89 + 2.517 2.499 -0.061
ENSG00000165458 E049 3.0143395 0.0546252552 2.023315e-01 3.291342e-01 11 72234616 72234646 31 + 0.683 0.482 -0.907
ENSG00000165458 E050 341.3629393 0.0002145914 8.572711e-01 9.118583e-01 11 72235116 72235203 88 + 2.457 2.488 0.103
ENSG00000165458 E051 368.5245307 0.0001455920 2.064743e-03 7.425759e-03 11 72235296 72235451 156 + 2.445 2.537 0.308
ENSG00000165458 E052 226.8175670 0.0001952565 1.556254e-08 1.850538e-07 11 72235675 72235753 79 + 2.161 2.346 0.621
ENSG00000165458 E053 146.7356729 0.0015435715 1.004073e-05 6.669888e-05 11 72235846 72235896 51 + 1.960 2.163 0.679
ENSG00000165458 E054 159.7421706 0.0002495719 8.024080e-07 6.800107e-06 11 72235897 72235986 90 + 2.003 2.196 0.644
ENSG00000165458 E055 188.0856404 0.0004635992 3.235232e-09 4.362934e-08 11 72237124 72237205 82 + 2.057 2.275 0.727
ENSG00000165458 E056 740.7808900 0.0026977127 2.109335e-11 4.164744e-10 11 72237206 72237659 454 + 2.647 2.873 0.752
ENSG00000165458 E057 335.0844403 0.0047106103 2.151759e-10 3.583270e-09 11 72237660 72237796 137 + 2.250 2.541 0.973
ENSG00000165458 E058 288.7947002 0.0046278025 7.603357e-09 9.579896e-08 11 72238042 72238175 134 + 2.201 2.473 0.907
ENSG00000165458 E059 5.6509019 0.0262682509 1.089720e-02 3.091777e-02 11 72238176 72238262 87 + 0.982 0.640 -1.352
ENSG00000165458 E060 1045.4862510 0.0032532418 1.021420e-17 5.015682e-16 11 72238263 72239020 758 + 2.750 3.033 0.941
ENSG00000165458 E061 62.4502451 0.0127093537 4.554333e-03 1.469354e-02 11 72239021 72239147 127 + 1.555 1.809 0.862