ENSG00000165392

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298139 ENSG00000165392 HEK293_OSMI2_2hA HEK293_TMG_2hB WRN protein_coding protein_coding 7.155998 0.8248984 13.74246 0.05724584 0.8592105 4.041945 3.4410700 0.63152537 6.6322883 0.10762767 0.55517304 3.372102 0.5488875 0.7891333 0.48843333 -0.3007 2.808654e-01 3.722706e-06 FALSE TRUE
ENST00000520169 ENSG00000165392 HEK293_OSMI2_2hA HEK293_TMG_2hB WRN protein_coding retained_intron 7.155998 0.8248984 13.74246 0.05724584 0.8592105 4.041945 1.1296897 0.02101778 2.3562169 0.02101778 0.03881194 6.253343 0.1495542 0.0262000 0.17250000 0.1463 8.613395e-03 3.722706e-06 FALSE FALSE
ENST00000651642 ENSG00000165392 HEK293_OSMI2_2hA HEK293_TMG_2hB WRN protein_coding protein_coding 7.155998 0.8248984 13.74246 0.05724584 0.8592105 4.041945 1.8170412 0.00000000 3.7892874 0.00000000 0.74473382 8.569585 0.1339167 0.0000000 0.27180000 0.2718 3.722706e-06 3.722706e-06 FALSE FALSE
MSTRG.31366.2 ENSG00000165392 HEK293_OSMI2_2hA HEK293_TMG_2hB WRN protein_coding   7.155998 0.8248984 13.74246 0.05724584 0.8592105 4.041945 0.6643593 0.17235528 0.8112879 0.17235528 0.50809991 2.171136 0.1228208 0.1846667 0.05596667 -0.1287 9.869415e-01 3.722706e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165392 E001 0.3030308 0.3410436775 1.000000e+00   8 31033788 31033797 10 + 0.082 0.000 -8.212
ENSG00000165392 E002 0.7427016 0.0156520649 1.000000e+00 1.0000000000 8 31033798 31033809 12 + 0.182 0.000 -9.453
ENSG00000165392 E003 21.8025489 0.0073452613 1.299070e-01 0.2340379066 8 31033810 31033973 164 + 1.180 1.008 -0.622
ENSG00000165392 E004 42.9025522 0.0009259725 4.866874e-02 0.1068047356 8 31058372 31058543 172 + 1.460 1.309 -0.522
ENSG00000165392 E005 38.7331086 0.0005219699 4.563653e-01 0.5968111343 8 31059153 31059265 113 + 1.405 1.370 -0.121
ENSG00000165392 E006 47.3541169 0.0004696520 9.796012e-01 0.9912908225 8 31064289 31064434 146 + 1.483 1.513 0.106
ENSG00000165392 E007 44.9472839 0.0009027958 3.669637e-01 0.5113243867 8 31064915 31065063 149 + 1.449 1.553 0.357
ENSG00000165392 E008 40.0248809 0.0128735044 3.949054e-01 0.5387430763 8 31067033 31067182 150 + 1.400 1.514 0.393
ENSG00000165392 E009 19.0676308 0.0305093081 4.992014e-01 0.6355274668 8 31068258 31068308 51 + 1.095 1.213 0.421
ENSG00000165392 E010 10.0493246 0.0726841511 1.933678e-01 0.3180083456 8 31068309 31068327 19 + 0.885 0.608 -1.128
ENSG00000165392 E011 23.7261195 0.0008274829 7.050136e-01 0.8034475944 8 31076173 31076287 115 + 1.191 1.263 0.254
ENSG00000165392 E012 65.4362966 0.0004063629 7.676133e-05 0.0004127439 8 31080867 31081296 430 + 1.644 1.351 -1.008
ENSG00000165392 E013 18.2385818 0.0052490427 1.130345e-01 0.2099675168 8 31083699 31083779 81 + 1.109 0.911 -0.729
ENSG00000165392 E014 34.1383138 0.0111434224 1.971683e-01 0.3226897250 8 31085166 31085246 81 + 1.357 1.241 -0.406
ENSG00000165392 E015 0.2987644 0.0273409591 1.000000e+00   8 31087644 31087775 132 + 0.082 0.000 -8.132
ENSG00000165392 E016 45.7286986 0.0234074298 8.608818e-02 0.1691381665 8 31087776 31087920 145 + 1.483 1.315 -0.581
ENSG00000165392 E017 32.4313747 0.0118725656 1.894750e-01 0.3130846976 8 31088890 31088965 76 + 1.338 1.214 -0.435
ENSG00000165392 E018 32.4054521 0.0114805467 1.212705e-01 0.2217364228 8 31090465 31090532 68 + 1.340 1.186 -0.542
ENSG00000165392 E019 32.3169736 0.0006921336 3.774497e-03 0.0125101420 8 31090834 31090942 109 + 1.352 1.049 -1.075
ENSG00000165392 E020 26.2764216 0.0007514539 8.690593e-02 0.1704425451 8 31091830 31091898 69 + 1.256 1.087 -0.602
ENSG00000165392 E021 32.7793421 0.0011394116 1.113511e-01 0.2075333233 8 31096768 31096850 83 + 1.346 1.212 -0.469
ENSG00000165392 E022 36.4251635 0.0006143724 1.939233e-02 0.0501830897 8 31100849 31100955 107 + 1.394 1.184 -0.735
ENSG00000165392 E023 53.0733587 0.0005645435 6.325248e-02 0.1321269880 8 31111615 31111799 185 + 1.543 1.423 -0.413
ENSG00000165392 E024 51.6051256 0.0008998506 9.257141e-02 0.1791392688 8 31116354 31116528 175 + 1.530 1.423 -0.367
ENSG00000165392 E025 7.4769990 0.0021491282 1.168905e-01 0.2155355233 8 31119956 31120242 287 + 0.777 0.483 -1.289
ENSG00000165392 E026 50.3938601 0.0049426428 1.051991e-01 0.1983978640 8 31120243 31120424 182 + 1.520 1.408 -0.386
ENSG00000165392 E027 49.1932558 0.0010721604 2.536800e-02 0.0626329845 8 31124522 31124623 102 + 1.515 1.351 -0.568
ENSG00000165392 E028 45.0269789 0.0005149116 1.213870e-01 0.2219044037 8 31124908 31125000 93 + 1.474 1.370 -0.358
ENSG00000165392 E029 49.1762565 0.0125119983 5.810354e-02 0.1233821860 8 31132365 31132506 142 + 1.514 1.353 -0.555
ENSG00000165392 E030 55.4797200 0.0005367342 8.364752e-01 0.8977425782 8 31141430 31141600 171 + 1.547 1.565 0.060
ENSG00000165392 E031 32.7000246 0.0029365463 3.945022e-01 0.5383288210 8 31141681 31141775 95 + 1.312 1.424 0.389
ENSG00000165392 E032 32.0096527 0.0007461711 9.657940e-01 0.9824827735 8 31142626 31142701 76 + 1.314 1.351 0.127
ENSG00000165392 E033 25.5458686 0.0495965359 9.657341e-01 0.9824639706 8 31143550 31143623 74 + 1.222 1.269 0.166
ENSG00000165392 E034 36.0217219 0.0006861580 6.075802e-01 0.7275138401 8 31147053 31147128 76 + 1.362 1.440 0.269
ENSG00000165392 E035 39.7929728 0.0007738927 7.452632e-02 0.1507821464 8 31147364 31147476 113 + 1.390 1.565 0.599
ENSG00000165392 E036 44.2738691 0.0006533107 4.882599e-03 0.0156030198 8 31150341 31150455 115 + 1.424 1.662 0.813
ENSG00000165392 E037 53.6217401 0.0004631437 6.293486e-03 0.0193832332 8 31154624 31154755 132 + 1.509 1.724 0.735
ENSG00000165392 E038 57.1801524 0.0004603322 1.229511e-03 0.0047409412 8 31157368 31157530 163 + 1.532 1.772 0.816
ENSG00000165392 E039 0.0000000       8 31162710 31162915 206 +      
ENSG00000165392 E040 72.4455701 0.0205472710 1.048548e-01 0.1978725230 8 31167022 31167230 209 + 1.639 1.828 0.640
ENSG00000165392 E041 169.1293250 0.0235184405 5.618987e-04 0.0023917056 8 31172995 31176138 3144 + 1.983 2.284 1.008