ENSG00000165359

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370752 ENSG00000165359 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS6L protein_coding protein_coding 3.065495 2.394334 3.565411 0.3256476 0.1580328 0.5724718 0.4488302 0.73555425 0.3957178 0.06274169 0.12028031 -0.8778368 0.15123750 0.3148000 0.11436667 -0.200433333 0.02997776 0.02997776 FALSE TRUE
ENST00000493637 ENSG00000165359 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS6L protein_coding retained_intron 3.065495 2.394334 3.565411 0.3256476 0.1580328 0.5724718 0.4486013 0.14216217 0.4598907 0.04414399 0.02739215 1.6267155 0.14133750 0.0591000 0.12980000 0.070700000 0.12113571 0.02997776 FALSE TRUE
ENST00000494957 ENSG00000165359 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS6L protein_coding processed_transcript 3.065495 2.394334 3.565411 0.3256476 0.1580328 0.5724718 0.2431295 0.09867014 0.1547502 0.09867014 0.15475018 0.6003245 0.07262083 0.0326000 0.04063333 0.008033333 0.97468889 0.02997776 FALSE TRUE
ENST00000639893 ENSG00000165359 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS6L protein_coding protein_coding 3.065495 2.394334 3.565411 0.3256476 0.1580328 0.5724718 1.3843970 0.70843530 1.7229586 0.13378938 0.14124029 1.2703071 0.44446667 0.3046333 0.48373333 0.179100000 0.18427805 0.02997776 FALSE TRUE
MSTRG.34949.4 ENSG00000165359 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS6L protein_coding   3.065495 2.394334 3.565411 0.3256476 0.1580328 0.5724718 0.3215923 0.51575611 0.4300275 0.26901915 0.21506869 -0.2567999 0.11919583 0.2071000 0.12206667 -0.085033333 0.91834971 0.02997776 FALSE TRUE
MSTRG.34949.6 ENSG00000165359 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS6L protein_coding   3.065495 2.394334 3.565411 0.3256476 0.1580328 0.5724718 0.1531204 0.11795589 0.4020667 0.05956118 0.24080157 1.6872311 0.05047917 0.0567000 0.10940000 0.052700000 0.92654745 0.02997776 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165359 E001 1.921837 0.2391683791 1.869510e-01 3.098952e-01 X 135520659 135520659 1 + 0.582 0.249 -1.866
ENSG00000165359 E002 12.260884 0.0226497383 1.809948e-01 3.024654e-01 X 135520660 135520992 333 + 1.187 1.020 -0.604
ENSG00000165359 E003 7.485783 0.0025366943 4.599575e-01 6.000177e-01 X 135520993 135521103 111 + 0.963 0.868 -0.359
ENSG00000165359 E004 1.739037 0.0977276936 4.865962e-01 6.243089e-01 X 135521198 135521240 43 + 0.383 0.509 0.654
ENSG00000165359 E005 10.160942 0.0016957471 3.438586e-01 4.879113e-01 X 135521241 135521318 78 + 1.090 0.984 -0.388
ENSG00000165359 E006 16.491326 0.0011084064 6.878842e-02 1.413638e-01 X 135545423 135545572 150 + 1.311 1.150 -0.569
ENSG00000165359 E007 15.242221 0.0011721678 4.293806e-02 9.642815e-02 X 135546380 135546469 90 + 1.287 1.101 -0.658
ENSG00000165359 E008 18.778228 0.0182423583 3.496535e-01 4.938590e-01 X 135546702 135546885 184 + 1.329 1.231 -0.344
ENSG00000165359 E009 15.606601 0.0409107779 4.591448e-02 1.018842e-01 X 135547137 135547265 129 + 1.312 1.058 -0.903
ENSG00000165359 E010 20.369003 0.0046991372 1.869513e-02 4.866561e-02 X 135549642 135549805 164 + 1.408 1.205 -0.708
ENSG00000165359 E011 22.992294 0.0125609117 4.766712e-02 1.050265e-01 X 135551994 135552146 153 + 1.458 1.270 -0.652
ENSG00000165359 E012 19.919978 0.0203392692 3.376532e-02 7.928237e-02 X 135556168 135556300 133 + 1.417 1.191 -0.792
ENSG00000165359 E013 14.047548 0.0654917958 1.533126e-01 2.661835e-01 X 135569337 135569431 95 + 1.274 1.044 -0.821
ENSG00000165359 E014 9.124503 0.1514897267 7.738421e-02 1.552774e-01 X 135569432 135570435 1004 + 1.120 0.793 -1.227
ENSG00000165359 E015 16.386216 0.0011947474 3.947986e-04 1.754560e-03 X 135570436 135570546 111 + 1.362 1.046 -1.120
ENSG00000165359 E016 18.404033 0.0012779965 7.987106e-05 4.272336e-04 X 135570547 135572814 2268 + 1.412 1.075 -1.190
ENSG00000165359 E017 27.187098 0.0009491917 2.310163e-01 3.636838e-01 X 135572815 135573033 219 + 1.486 1.398 -0.303
ENSG00000165359 E018 24.371839 0.0040465690 2.202259e-01 3.506863e-01 X 135573939 135574062 124 + 1.449 1.350 -0.342
ENSG00000165359 E019 30.519857 0.0007051240 8.633258e-01 9.158356e-01 X 135575084 135575226 143 + 1.506 1.486 -0.067
ENSG00000165359 E020 27.005477 0.0008117782 8.549970e-01 9.103236e-01 X 135577193 135577295 103 + 1.444 1.447 0.010
ENSG00000165359 E021 19.770153 0.0018849681 1.215967e-01 2.222085e-01 X 135577296 135577427 132 + 1.254 1.365 0.387
ENSG00000165359 E022 24.406649 0.0100136852 1.469785e-01 2.575704e-01 X 135579788 135579884 97 + 1.351 1.458 0.370
ENSG00000165359 E023 23.359067 0.0014874313 1.361606e-02 3.734649e-02 X 135579885 135579936 52 + 1.299 1.464 0.573
ENSG00000165359 E024 47.298940 0.0004787273 2.250445e-02 5.672962e-02 X 135579937 135580162 226 + 1.628 1.732 0.350
ENSG00000165359 E025 28.612633 0.0007631668 7.418187e-02 1.502280e-01 X 135581050 135581143 94 + 1.412 1.517 0.361
ENSG00000165359 E026 20.279752 0.0010597974 6.282240e-02 1.314114e-01 X 135581528 135581564 37 + 1.254 1.385 0.458
ENSG00000165359 E027 23.742963 0.0009006728 1.249413e-02 3.472007e-02 X 135581565 135581631 67 + 1.305 1.470 0.571
ENSG00000165359 E028 66.575354 0.0006214824 1.602511e-09 2.286953e-08 X 135581632 135582240 609 + 1.695 1.939 0.823
ENSG00000165359 E029 22.418862 0.0208152331 1.508195e-03 5.662714e-03 X 135582241 135582510 270 + 1.203 1.501 1.039