ENSG00000165322

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311380 ENSG00000165322 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP12 protein_coding protein_coding 2.985219 1.041944 4.664304 0.07248813 0.2292365 2.151693 0.53152507 0.18136682 0.8902910 0.18136682 0.09835741 2.234051 0.16240417 0.19993333 0.19090000 -0.009033333 6.072957e-01 2.851259e-05 FALSE TRUE
ENST00000344936 ENSG00000165322 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP12 protein_coding protein_coding 2.985219 1.041944 4.664304 0.07248813 0.2292365 2.151693 0.86954811 0.14182297 1.1634942 0.07228971 0.60787025 2.950349 0.23751250 0.14616667 0.25676667 0.110600000 9.208880e-01 2.851259e-05 FALSE TRUE
ENST00000375245 ENSG00000165322 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP12 protein_coding protein_coding 2.985219 1.041944 4.664304 0.07248813 0.2292365 2.151693 0.21259382 0.10818697 0.7019242 0.05998593 0.37620562 2.590653 0.06773333 0.09656667 0.15053333 0.053966667 9.499191e-01 2.851259e-05 FALSE TRUE
ENST00000375250 ENSG00000165322 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP12 protein_coding protein_coding 2.985219 1.041944 4.664304 0.07248813 0.2292365 2.151693 0.61025495 0.00000000 1.3798628 0.00000000 0.37986923 7.118799 0.17592500 0.00000000 0.29183333 0.291833333 2.851259e-05 2.851259e-05 FALSE TRUE
ENST00000396144 ENSG00000165322 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP12 protein_coding protein_coding 2.985219 1.041944 4.664304 0.07248813 0.2292365 2.151693 0.06441223 0.11283962 0.0000000 0.11283962 0.00000000 -3.618704 0.03642917 0.09763333 0.00000000 -0.097633333 4.862906e-01 2.851259e-05 FALSE TRUE
ENST00000492028 ENSG00000165322 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP12 protein_coding processed_transcript 2.985219 1.041944 4.664304 0.07248813 0.2292365 2.151693 0.04431043 0.09692266 0.0000000 0.09692266 0.00000000 -3.418496 0.04086250 0.09116667 0.00000000 -0.091166667 5.044717e-01 2.851259e-05 FALSE TRUE
ENST00000493008 ENSG00000165322 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP12 protein_coding processed_transcript 2.985219 1.041944 4.664304 0.07248813 0.2292365 2.151693 0.25397030 0.04200235 0.3884952 0.04200235 0.14771504 2.937914 0.12446667 0.04630000 0.08193333 0.035633333 6.822841e-01 2.851259e-05 FALSE TRUE
ENST00000497085 ENSG00000165322 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP12 protein_coding processed_transcript 2.985219 1.041944 4.664304 0.07248813 0.2292365 2.151693 0.15019114 0.35880298 0.1402368 0.18411483 0.14023684 -1.295612 0.09575000 0.32220000 0.02810000 -0.294100000 3.063355e-01 2.851259e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165322 E001 0.0000000       10 31805398 31805403 6 -      
ENSG00000165322 E002 0.0000000       10 31805404 31805436 33 -      
ENSG00000165322 E003 5.6664357 0.0798600846 6.337604e-03 1.950104e-02 10 31805437 31805713 277 - 0.591 1.110 2.036
ENSG00000165322 E004 19.4975301 0.0365210592 1.414429e-04 7.097695e-04 10 31805714 31806290 577 - 1.076 1.558 1.687
ENSG00000165322 E005 1.2983090 0.0109841334 3.053638e-03 1.042385e-02 10 31806291 31806293 3 - 0.150 0.685 3.214
ENSG00000165322 E006 117.6501453 0.0002874338 9.658500e-10 1.436243e-08 10 31806294 31807832 1539 - 1.911 2.134 0.748
ENSG00000165322 E007 0.3030308 0.3560569135 1.000000e+00   10 31808453 31808648 196 - 0.106 0.000 -10.160
ENSG00000165322 E008 19.6609018 0.0011818490 2.915805e-01 4.324537e-01 10 31808649 31808751 103 - 1.219 1.124 -0.341
ENSG00000165322 E009 19.5486918 0.0009853448 3.249148e-02 7.678813e-02 10 31808994 31809128 135 - 1.234 1.009 -0.807
ENSG00000165322 E010 1.4769841 0.0089916159 1.337944e-01 2.394271e-01 10 31809129 31809229 101 - 0.376 0.000 -13.092
ENSG00000165322 E011 17.0470562 0.0010531379 1.375747e-02 3.767163e-02 10 31809230 31809307 78 - 1.186 0.898 -1.052
ENSG00000165322 E012 1.6931308 0.0094199462 8.227674e-01 8.882526e-01 10 31809308 31809685 378 - 0.350 0.404 0.309
ENSG00000165322 E013 15.8092978 0.0011696677 3.567613e-01 5.011539e-01 10 31810649 31810747 99 - 1.132 1.041 -0.329
ENSG00000165322 E014 0.0000000       10 31812636 31812706 71 -      
ENSG00000165322 E015 17.7745980 0.0010113347 4.769615e-01 6.155618e-01 10 31812707 31812823 117 - 1.149 1.234 0.301
ENSG00000165322 E016 18.9557107 0.0022993581 5.381790e-01 6.696297e-01 10 31814259 31814361 103 - 1.178 1.253 0.265
ENSG00000165322 E017 18.6998207 0.0022655179 3.506065e-01 4.947918e-01 10 31817788 31817886 99 - 1.166 1.271 0.372
ENSG00000165322 E018 19.0481315 0.0010065714 5.290767e-01 6.619242e-01 10 31820387 31820443 57 - 1.178 1.253 0.265
ENSG00000165322 E019 16.6618205 0.0017061473 9.792982e-01 9.911096e-01 10 31820444 31820488 45 - 1.132 1.148 0.058
ENSG00000165322 E020 18.0432764 0.0010715620 5.185935e-01 6.528319e-01 10 31826304 31826385 82 - 1.178 1.124 -0.194
ENSG00000165322 E021 0.1482932 0.0411116371 7.085393e-02   10 31826785 31826974 190 - 0.000 0.247 12.423
ENSG00000165322 E022 17.0040030 0.0010752689 2.163195e-01 3.459776e-01 10 31831739 31831800 62 - 1.166 1.041 -0.450
ENSG00000165322 E023 5.6276034 0.0204678937 7.402237e-01 8.296937e-01 10 31839305 31839319 15 - 0.733 0.685 -0.197
ENSG00000165322 E024 11.0582126 0.0023574774 9.313599e-01 9.607559e-01 10 31839637 31839711 75 - 0.973 0.976 0.008
ENSG00000165322 E025 16.9914182 0.0010676320 2.163550e-01 3.460141e-01 10 31843461 31843586 126 - 1.166 1.041 -0.450
ENSG00000165322 E026 17.2490684 0.0012648461 3.011849e-01 4.429703e-01 10 31852517 31852597 81 - 1.170 1.070 -0.358
ENSG00000165322 E027 14.3193669 0.0013311525 3.531370e-02 8.225535e-02 10 31854066 31854206 141 - 1.114 0.854 -0.964
ENSG00000165322 E028 35.9816672 0.0006229747 3.550307e-07 3.234563e-06 10 31861395 31861658 264 - 1.513 1.041 -1.661
ENSG00000165322 E029 54.6875848 0.0009192896 3.243340e-05 1.913431e-04 10 31908172 31908926 755 - 1.671 1.395 -0.947
ENSG00000165322 E030 6.4355461 0.0025850957 2.284957e-02 5.742547e-02 10 31910525 31910563 39 - 0.823 0.404 -1.879
ENSG00000165322 E031 7.3233066 0.0022485619 9.657270e-03 2.791999e-02 10 31928683 31928876 194 - 0.874 0.404 -2.076