ENSG00000165288

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373275 ENSG00000165288 HEK293_OSMI2_2hA HEK293_TMG_2hB BRWD3 protein_coding protein_coding 2.84376 0.642851 4.678252 0.03839882 0.1947612 2.844224 1.545861 0.58651037 2.430479 0.007248309 0.02940541 2.032545 0.6259625 0.91773333 0.5208333 -0.3969000 1.301503e-05 1.301503e-05 FALSE TRUE
ENST00000473691 ENSG00000165288 HEK293_OSMI2_2hA HEK293_TMG_2hB BRWD3 protein_coding processed_transcript 2.84376 0.642851 4.678252 0.03839882 0.1947612 2.844224 1.228971 0.05634063 2.071039 0.032796542 0.08651085 4.971268 0.3554958 0.08226667 0.4427000 0.3604333 3.419996e-05 1.301503e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165288 E001 274.8158169 0.0003855197 1.458282e-24 1.528872e-22 X 80669503 80677244 7742 - 2.291 2.508 0.723
ENSG00000165288 E002 26.0940707 0.0009606128 4.762101e-02 1.049478e-01 X 80677245 80677363 119 - 1.306 1.461 0.536
ENSG00000165288 E003 26.7595483 0.0007494568 8.556289e-01 9.107378e-01 X 80681341 80681499 159 - 1.351 1.365 0.047
ENSG00000165288 E004 21.0880238 0.0016874790 4.559802e-01 5.964557e-01 X 80681997 80682094 98 - 1.241 1.308 0.233
ENSG00000165288 E005 23.1442361 0.0007986350 8.626978e-01 9.154602e-01 X 80682465 80682628 164 - 1.293 1.276 -0.060
ENSG00000165288 E006 14.8552887 0.0011759963 6.687627e-01 7.756953e-01 X 80684010 80684089 80 - 1.098 1.142 0.158
ENSG00000165288 E007 15.9672347 0.0013241357 3.591789e-01 5.035102e-01 X 80684090 80684162 73 - 1.114 1.205 0.327
ENSG00000165288 E008 13.2501203 0.0179722032 8.935105e-01 9.359090e-01 X 80685462 80685536 75 - 1.066 1.044 -0.081
ENSG00000165288 E009 18.1995982 0.0010578784 2.605408e-01 3.980828e-01 X 80686863 80687003 141 - 1.215 1.095 -0.427
ENSG00000165288 E010 14.3727330 0.0012175654 5.670147e-01 6.939003e-01 X 80688069 80688125 57 - 1.109 1.042 -0.241
ENSG00000165288 E011 13.9739621 0.0012621207 4.699937e-01 6.092096e-01 X 80689768 80689846 79 - 1.098 1.013 -0.312
ENSG00000165288 E012 17.6244691 0.0012270715 9.309043e-01 9.605293e-01 X 80689967 80690092 126 - 1.178 1.185 0.025
ENSG00000165288 E013 17.6519744 0.0066765645 4.379934e-01 5.798681e-01 X 80691053 80691173 121 - 1.165 1.242 0.273
ENSG00000165288 E014 20.4841793 0.0010964309 6.617668e-01 7.701708e-01 X 80691823 80691978 156 - 1.249 1.205 -0.155
ENSG00000165288 E015 13.5293300 0.0012989635 9.932746e-01 9.999516e-01 X 80692089 80692150 62 - 1.072 1.069 -0.009
ENSG00000165288 E016 16.7838588 0.0011499067 3.024560e-01 4.443326e-01 X 80692940 80693051 112 - 1.142 1.242 0.353
ENSG00000165288 E017 11.0492884 0.0102465731 3.286230e-01 4.721205e-01 X 80695908 80695990 83 - 0.975 1.094 0.436
ENSG00000165288 E018 16.3330023 0.0011500348 6.652034e-01 7.728966e-01 X 80696739 80696863 125 - 1.142 1.185 0.152
ENSG00000165288 E019 17.2809089 0.0018383338 1.582231e-01 2.727516e-01 X 80699957 80700064 108 - 1.199 1.042 -0.564
ENSG00000165288 E020 17.2464655 0.0012289779 2.497411e-01 3.856218e-01 X 80703480 80703593 114 - 1.195 1.069 -0.450
ENSG00000165288 E021 24.4929860 0.0050369799 1.253903e-03 4.822923e-03 X 80704678 80704846 169 - 1.366 1.013 -1.256
ENSG00000165288 E022 16.2218385 0.0012593959 9.693747e-03 2.800621e-02 X 80707427 80707503 77 - 1.190 0.872 -1.171
ENSG00000165288 E023 22.2627107 0.0091228081 9.113862e-03 2.656830e-02 X 80709428 80709577 150 - 1.318 1.014 -1.087
ENSG00000165288 E024 17.2421881 0.0012716785 5.036896e-04 2.173980e-03 X 80716157 80716250 94 - 1.226 0.779 -1.660
ENSG00000165288 E025 0.0000000       X 80716883 80717572 690 -      
ENSG00000165288 E026 20.9890436 0.0008937828 1.636329e-03 6.077787e-03 X 80717573 80717759 187 - 1.300 0.948 -1.267
ENSG00000165288 E027 21.3733548 0.0008867882 5.198336e-02 1.126976e-01 X 80719489 80719656 168 - 1.293 1.095 -0.705
ENSG00000165288 E028 24.7655408 0.0076540802 3.374381e-01 4.813390e-01 X 80722562 80722787 226 - 1.337 1.242 -0.334
ENSG00000165288 E029 14.0645064 0.0012580046 1.733370e-01 2.925372e-01 X 80723748 80723876 129 - 1.114 0.948 -0.607
ENSG00000165288 E030 16.6190398 0.0011217267 2.539431e-03 8.881727e-03 X 80724933 80725067 135 - 1.207 0.828 -1.399
ENSG00000165288 E031 20.1138708 0.0010211467 3.345739e-04 1.518726e-03 X 80728752 80728905 154 - 1.293 0.871 -1.535
ENSG00000165288 E032 15.2950427 0.0011238102 2.311098e-03 8.185740e-03 X 80729916 80730020 105 - 1.178 0.779 -1.489
ENSG00000165288 E033 0.5933762 0.0234326738 5.296252e-01 6.623794e-01 X 80733158 80733455 298 - 0.202 0.000 -11.100
ENSG00000165288 E034 10.3224400 0.0017653326 1.155716e-03 4.490760e-03 X 80733456 80733496 41 - 1.032 0.498 -2.186
ENSG00000165288 E035 12.6924832 0.0013548770 1.229607e-05 8.001698e-05 X 80734118 80734218 101 - 1.123 0.386 -3.102
ENSG00000165288 E036 8.8161854 0.0020038880 1.076635e-04 5.573583e-04 X 80735127 80735197 71 - 0.982 0.234 -3.585
ENSG00000165288 E037 8.5963570 0.0020379886 5.720066e-01 6.981802e-01 X 80735988 80736088 101 - 0.909 0.828 -0.311
ENSG00000165288 E038 0.1472490 0.0423983700 1.000000e+00   X 80743707 80744031 325 - 0.060 0.000 -9.118
ENSG00000165288 E039 16.2556069 0.0013792663 9.839420e-01 9.940426e-01 X 80744032 80744253 222 - 1.142 1.143 0.001
ENSG00000165288 E040 14.7086694 0.0027126495 5.167669e-01 6.512942e-01 X 80745569 80745729 161 - 1.118 1.042 -0.276
ENSG00000165288 E041 9.3774155 0.0238303527 1.415561e-01 2.501597e-01 X 80791854 80791952 99 - 0.968 0.724 -0.947
ENSG00000165288 E042 12.1054620 0.0318737722 4.756146e-01 6.143256e-01 X 80793622 80793772 151 - 1.007 1.097 0.325
ENSG00000165288 E043 8.0154126 0.0386532054 8.157612e-01 8.834086e-01 X 80808539 80808598 60 - 0.876 0.829 -0.179
ENSG00000165288 E044 5.5723191 0.0040288405 7.135149e-01 8.100008e-01 X 80809013 80809042 30 - 0.724 0.779 0.223
ENSG00000165288 E045 4.0890068 0.0059269594 5.010645e-01 6.372442e-01 X 80809246 80809304 59 - 0.614 0.723 0.465
ENSG00000165288 E046 5.9282312 0.0572135533 2.838778e-01 4.240740e-01 X 80809441 80809662 222 - 0.801 0.584 -0.907
ENSG00000165288 E047 3.9889778 0.0045136305 2.857450e-03 9.846146e-03 X 80809663 80809877 215 - 0.699 0.000 -13.678
ENSG00000165288 E048 0.1472490 0.0423983700 1.000000e+00   X 80810741 80811252 512 - 0.060 0.000 -9.118