ENSG00000165283

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356493 ENSG00000165283 HEK293_OSMI2_2hA HEK293_TMG_2hB STOML2 protein_coding protein_coding 381.3207 624.2667 265.5589 13.4212 1.412453 -1.2331 244.79326 447.76767 161.60471 29.3136332 6.9669967 -1.4702241 0.619375 0.71760000 0.6083000 -0.10930000 2.613888e-01 1.178653e-39 FALSE TRUE
ENST00000487490 ENSG00000165283 HEK293_OSMI2_2hA HEK293_TMG_2hB STOML2 protein_coding processed_transcript 381.3207 624.2667 265.5589 13.4212 1.412453 -1.2331 18.51932 13.04587 19.47443 0.4156038 0.8451353 0.5776234 0.058775 0.02086667 0.0734000 0.05253333 1.178653e-39 1.178653e-39   FALSE
MSTRG.32608.4 ENSG00000165283 HEK293_OSMI2_2hA HEK293_TMG_2hB STOML2 protein_coding   381.3207 624.2667 265.5589 13.4212 1.412453 -1.2331 98.89378 141.55956 67.94069 30.2446907 4.1025567 -1.0589510 0.266950 0.22626667 0.2560333 0.02976667 7.979557e-01 1.178653e-39 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165283 E001 1.025569 0.0121989077 6.882077e-01 7.903810e-01 9 35099776 35099777 2 - 0.319 0.251 -0.474
ENSG00000165283 E002 3.126969 0.0049202751 5.802385e-01 7.050100e-01 9 35099778 35099890 113 - 0.629 0.548 -0.361
ENSG00000165283 E003 40.124238 0.0065692377 2.082864e-09 2.905687e-08 9 35099891 35099893 3 - 1.053 1.628 2.007
ENSG00000165283 E004 43.086532 0.0047390212 7.197819e-07 6.165417e-06 9 35099894 35099894 1 - 1.224 1.644 1.452
ENSG00000165283 E005 45.671609 0.0032910044 2.053162e-06 1.593011e-05 9 35099895 35099895 1 - 1.289 1.663 1.289
ENSG00000165283 E006 875.995924 0.0023321460 2.613398e-04 1.222048e-03 9 35099896 35100005 110 - 2.777 2.893 0.387
ENSG00000165283 E007 1096.928101 0.0032295269 1.590413e-02 4.251973e-02 9 35100006 35100024 19 - 2.897 2.985 0.294
ENSG00000165283 E008 3975.668519 0.0018203020 7.786244e-03 2.324243e-02 9 35100025 35100172 148 - 3.471 3.539 0.227
ENSG00000165283 E009 4388.774247 0.0013174587 1.581401e-04 7.834689e-04 9 35100598 35100726 129 - 3.505 3.584 0.265
ENSG00000165283 E010 66.269593 0.0019952269 9.984526e-11 1.761537e-09 9 35100727 35100931 205 - 1.967 1.660 -1.036
ENSG00000165283 E011 2968.515961 0.0002651417 1.005911e-14 3.306155e-13 9 35100932 35101011 80 - 3.322 3.419 0.321
ENSG00000165283 E012 4831.077401 0.0002318031 1.150218e-01 2.128709e-01 9 35101135 35101279 145 - 3.589 3.615 0.088
ENSG00000165283 E013 2584.611059 0.0005970848 1.567780e-03 5.854630e-03 9 35101426 35101449 24 - 3.361 3.330 -0.105
ENSG00000165283 E014 4158.008818 0.0006344032 2.491242e-04 1.171490e-03 9 35101450 35101560 111 - 3.570 3.535 -0.116
ENSG00000165283 E015 3641.659723 0.0001089635 7.802201e-08 8.091661e-07 9 35101710 35101780 71 - 3.509 3.479 -0.100
ENSG00000165283 E016 2803.911231 0.0002288527 8.562422e-07 7.215217e-06 9 35101781 35101811 31 - 3.401 3.364 -0.124
ENSG00000165283 E017 3147.767872 0.0002334571 4.605321e-05 2.617968e-04 9 35101904 35101962 59 - 3.444 3.416 -0.092
ENSG00000165283 E018 3451.455103 0.0003761667 2.992321e-03 1.024208e-02 9 35102095 35102194 100 - 3.478 3.458 -0.068
ENSG00000165283 E019 95.356406 0.0008915387 3.287057e-45 1.549062e-42 9 35102195 35102364 170 - 2.250 1.717 -1.790
ENSG00000165283 E020 2874.877518 0.0011272467 4.573894e-01 5.977088e-01 9 35102686 35102823 138 - 3.384 3.383 -0.002
ENSG00000165283 E021 37.224538 0.0005778562 4.937702e-10 7.736604e-09 9 35102910 35102946 37 - 1.751 1.395 -1.216
ENSG00000165283 E022 27.769288 0.0009532066 1.379176e-05 8.869301e-05 9 35102947 35102953 7 - 1.585 1.296 -0.998
ENSG00000165283 E023 70.568149 0.0034162552 9.236664e-07 7.720871e-06 9 35102954 35103049 96 - 1.952 1.706 -0.828
ENSG00000165283 E024 1273.078013 0.0026508467 2.086723e-01 3.369100e-01 9 35103050 35103160 111 - 2.993 3.040 0.156
ENSG00000165283 E025 41.492655 0.0007279766 5.081509e-01 6.436037e-01 9 35103161 35103258 98 - 1.579 1.551 -0.095