ENSG00000165259

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297977 ENSG00000165259 HEK293_OSMI2_2hA HEK293_TMG_2hB HDX protein_coding protein_coding 0.9677922 0.404589 1.601561 0.1229944 0.1757935 1.958705 0.23134420 0.02469270 0.29796166 0.02469270 0.12144901 3.15004676 0.26018750 0.1542667 0.1771000 0.02283333 6.902109e-01 7.560616e-06 FALSE TRUE
ENST00000373177 ENSG00000165259 HEK293_OSMI2_2hA HEK293_TMG_2hB HDX protein_coding protein_coding 0.9677922 0.404589 1.601561 0.1229944 0.1757935 1.958705 0.08087009 0.00000000 0.21576901 0.00000000 0.16734995 4.49677557 0.05575833 0.0000000 0.1584333 0.15843333 6.930269e-01 7.560616e-06 FALSE TRUE
ENST00000465509 ENSG00000165259 HEK293_OSMI2_2hA HEK293_TMG_2hB HDX protein_coding processed_transcript 0.9677922 0.404589 1.601561 0.1229944 0.1757935 1.958705 0.11385048 0.19779193 0.19419665 0.10253649 0.06409024 -0.02518047 0.12338333 0.3787667 0.1174667 -0.26130000 3.490212e-02 7.560616e-06   FALSE
ENST00000472135 ENSG00000165259 HEK293_OSMI2_2hA HEK293_TMG_2hB HDX protein_coding retained_intron 0.9677922 0.404589 1.601561 0.1229944 0.1757935 1.958705 0.06205215 0.05841135 0.06265360 0.03779889 0.01665253 0.08679843 0.09351667 0.1087667 0.0382000 -0.07056667 3.496447e-01 7.560616e-06 FALSE TRUE
ENST00000506585 ENSG00000165259 HEK293_OSMI2_2hA HEK293_TMG_2hB HDX protein_coding protein_coding 0.9677922 0.404589 1.601561 0.1229944 0.1757935 1.958705 0.03631780 0.12369301 0.04152653 0.02503798 0.02338255 -1.37553662 0.11346250 0.3582000 0.0232000 -0.33500000 4.974112e-04 7.560616e-06 FALSE TRUE
MSTRG.34532.4 ENSG00000165259 HEK293_OSMI2_2hA HEK293_TMG_2hB HDX protein_coding   0.9677922 0.404589 1.601561 0.1229944 0.1757935 1.958705 0.44335748 0.00000000 0.78945316 0.00000000 0.14634094 6.32094161 0.35369167 0.0000000 0.4855000 0.48550000 7.560616e-06 7.560616e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165259 E001 0.000000       X 84317874 84317877 4 -      
ENSG00000165259 E002 30.131768 0.0007564672 0.02451776 0.06088528 X 84317878 84321726 3849 - 1.381 1.518 0.470
ENSG00000165259 E003 10.994928 0.0042055463 0.83620226 0.89758181 X 84321727 84322014 288 - 1.002 1.022 0.073
ENSG00000165259 E004 6.045806 0.0037036403 0.81684055 0.88415561 X 84326178 84326300 123 - 0.777 0.808 0.124
ENSG00000165259 E005 4.093159 0.0055757725 0.63011897 0.74534773 X 84333759 84333842 84 - 0.631 0.705 0.317
ENSG00000165259 E006 5.366177 0.1101600781 0.37021172 0.51465020 X 84336801 84336880 80 - 0.776 0.567 -0.884
ENSG00000165259 E007 9.331823 0.0024488398 0.21995231 0.35036623 X 84344250 84344457 208 - 0.974 0.809 -0.631
ENSG00000165259 E008 7.335988 0.0025740490 0.46006786 0.60012033 X 84361466 84361612 147 - 0.869 0.760 -0.425
ENSG00000165259 E009 1.217770 0.0113778388 0.04655703 0.10304484 X 84439973 84440531 559 - 0.210 0.570 2.123
ENSG00000165259 E010 2.741984 0.0058737293 0.83509132 0.89678565 X 84440532 84440585 54 - 0.523 0.483 -0.197
ENSG00000165259 E011 12.053760 0.0014636202 0.38323771 0.52741747 X 84468472 84468927 456 - 1.064 0.962 -0.378
ENSG00000165259 E012 14.025143 0.0014586232 0.24072337 0.37502807 X 84468928 84469575 648 - 1.124 0.993 -0.478
ENSG00000165259 E013 0.000000       X 84469576 84469576 1 -      
ENSG00000165259 E014 3.758294 0.0734920904 0.05755512 0.12242484 X 84475251 84475397 147 - 0.675 0.226 -2.450
ENSG00000165259 E015 2.273822 0.1455444000 0.73207237 0.82362977 X 84488024 84488132 109 - 0.480 0.373 -0.567
ENSG00000165259 E016 1.251181 0.0116805651 0.04567370 0.10143662 X 84500025 84500304 280 - 0.210 0.570 2.124
ENSG00000165259 E017 1.396354 0.0105810707 0.07626101 0.15352282 X 84501429 84501511 83 - 0.250 0.570 1.802
ENSG00000165259 E018 5.672554 0.0032583819 0.71515613 0.81115696 X 84502342 84502479 138 - 0.766 0.706 -0.244