ENSG00000165195

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333590 ENSG00000165195 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGA protein_coding protein_coding 8.726761 2.710636 13.73702 0.4644627 0.4112189 2.337103 4.6546000 1.34580131 7.3425453 0.15827095 0.91361739 2.439098 0.49224583 0.53293333 0.53153333 -0.00140000 1.000000e+00 4.193172e-06 FALSE TRUE
ENST00000634484 ENSG00000165195 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGA protein_coding retained_intron 8.726761 2.710636 13.73702 0.4644627 0.4112189 2.337103 0.4277510 0.08607525 0.8504335 0.03213584 0.11065709 3.162827 0.05029583 0.03770000 0.06223333 0.02453333 4.256226e-01 4.193172e-06   FALSE
ENST00000634640 ENSG00000165195 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGA protein_coding protein_coding 8.726761 2.710636 13.73702 0.4644627 0.4112189 2.337103 0.4882637 0.00000000 0.8753843 0.00000000 0.43807576 6.468232 0.03737917 0.00000000 0.06556667 0.06556667 4.356838e-01 4.193172e-06 FALSE FALSE
ENST00000635598 ENSG00000165195 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGA protein_coding nonsense_mediated_decay 8.726761 2.710636 13.73702 0.4644627 0.4112189 2.337103 0.4683150 0.22912192 1.0724578 0.16240458 0.03165206 2.178493 0.06742500 0.08193333 0.07813333 -0.00380000 8.478849e-01 4.193172e-06 FALSE TRUE
ENST00000635631 ENSG00000165195 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGA protein_coding processed_transcript 8.726761 2.710636 13.73702 0.4644627 0.4112189 2.337103 0.2220998 0.79894751 0.0000000 0.47022171 0.00000000 -6.337974 0.08254583 0.24990000 0.00000000 -0.24990000 3.163181e-02 4.193172e-06 FALSE TRUE
ENST00000637799 ENSG00000165195 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGA protein_coding processed_transcript 8.726761 2.710636 13.73702 0.4644627 0.4112189 2.337103 0.8322488 0.00000000 1.0571143 0.00000000 0.11800499 6.737571 0.07320417 0.00000000 0.07660000 0.07660000 4.193172e-06 4.193172e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165195 E001 0.0000000       X 15319452 15319454 3 -      
ENSG00000165195 E002 0.0000000       X 15319455 15319455 1 -      
ENSG00000165195 E003 0.1817044 0.0524559715 9.816713e-02   X 15319456 15319456 1 - 0.000 0.230 10.921
ENSG00000165195 E004 2.2830943 0.0072433587 1.888183e-02 4.907406e-02 X 15319457 15319474 18 - 0.345 0.769 2.003
ENSG00000165195 E005 8.5664937 0.0249591206 1.845757e-06 1.446957e-05 X 15319475 15319499 25 - 0.667 1.335 2.501
ENSG00000165195 E006 128.9797052 0.0070078947 1.786325e-20 1.207758e-18 X 15319500 15320358 859 - 1.879 2.352 1.583
ENSG00000165195 E007 170.1256187 0.0003085577 2.743935e-05 1.647222e-04 X 15320359 15321324 966 - 2.108 2.272 0.547
ENSG00000165195 E008 29.9747991 0.0031735316 9.523639e-01 9.741554e-01 X 15321325 15321426 102 - 1.403 1.438 0.121
ENSG00000165195 E009 42.8082973 0.0005880566 1.846843e-01 3.070803e-01 X 15321427 15321564 138 - 1.566 1.519 -0.161
ENSG00000165195 E010 50.7129380 0.0004523227 1.483095e-03 5.582291e-03 X 15321565 15321700 136 - 1.655 1.491 -0.560
ENSG00000165195 E011 23.7144966 0.0013425047 3.186391e-02 7.558880e-02 X 15321701 15321712 12 - 1.336 1.174 -0.567
ENSG00000165195 E012 35.6432406 0.0006356728 8.345542e-02 1.649647e-01 X 15321713 15321772 60 - 1.492 1.405 -0.302
ENSG00000165195 E013 31.6388017 0.0087231969 1.805660e-01 3.018920e-01 X 15324665 15324731 67 - 1.443 1.366 -0.266
ENSG00000165195 E014 29.5497293 0.0008507612 1.565932e-01 2.705626e-01 X 15324732 15324785 54 - 1.414 1.341 -0.253
ENSG00000165195 E015 29.4325310 0.0006533302 2.354736e-01 3.689319e-01 X 15324786 15324871 86 - 1.408 1.354 -0.187
ENSG00000165195 E016 1.7830217 0.0862028276 3.293956e-01 4.729041e-01 X 15324872 15325019 148 - 0.427 0.229 -1.270
ENSG00000165195 E017 43.0460164 0.0007533846 1.486813e-02 4.019296e-02 X 15325020 15325152 133 - 1.579 1.450 -0.441
ENSG00000165195 E018 1.7661836 0.0077945600 2.944841e-01 4.355771e-01 X 15325153 15325272 120 - 0.427 0.230 -1.262
ENSG00000165195 E019 1.7328847 0.0079191110 9.263655e-01 9.576286e-01 X 15325607 15325913 307 - 0.374 0.379 0.029
ENSG00000165195 E020 35.1337088 0.0007210062 1.808940e-04 8.817885e-04 X 15325914 15325969 56 - 1.513 1.249 -0.917
ENSG00000165195 E021 38.4614805 0.0010659644 8.334660e-05 4.438319e-04 X 15325970 15326046 77 - 1.552 1.282 -0.934
ENSG00000165195 E022 4.8360765 0.0032857447 3.043401e-01 4.463457e-01 X 15326047 15326383 337 - 0.720 0.578 -0.609
ENSG00000165195 E023 1.4842573 0.0504827782 4.397682e-01 5.815169e-01 X 15326950 15327255 306 - 0.374 0.229 -0.977
ENSG00000165195 E024 6.6934093 0.0088706681 7.113535e-02 1.452260e-01 X 15327637 15328220 584 - 0.850 0.579 -1.122
ENSG00000165195 E025 6.8226637 0.0025713178 2.813233e-03 9.713322e-03 X 15328221 15328343 123 - 0.886 0.379 -2.261
ENSG00000165195 E026 4.0986735 0.0039114328 2.510420e-01 3.871823e-01 X 15328344 15328537 194 - 0.667 0.490 -0.801
ENSG00000165195 E027 6.4699738 0.0027302086 8.313282e-02 1.644660e-01 X 15328538 15328956 419 - 0.831 0.579 -1.049
ENSG00000165195 E028 1.0371996 0.0299284886 1.845387e-01 3.069062e-01 X 15330920 15330975 56 - 0.315 0.000 -14.083
ENSG00000165195 E029 34.4174881 0.0005974347 1.157486e-03 4.496806e-03 X 15331216 15331299 84 - 1.501 1.282 -0.760
ENSG00000165195 E030 43.2170236 0.0004951415 2.189235e-01 3.491112e-01 X 15331300 15331473 174 - 1.568 1.528 -0.136
ENSG00000165195 E031 38.9936636 0.0005981943 2.218724e-01 3.526323e-01 X 15331474 15331589 116 - 1.525 1.481 -0.151
ENSG00000165195 E032 55.5377992 0.0004631392 2.309264e-02 5.793940e-02 X 15331590 15331819 230 - 1.682 1.587 -0.323
ENSG00000165195 E033 31.6394201 0.0006214647 2.225776e-02 5.620797e-02 X 15331820 15331873 54 - 1.455 1.312 -0.494
ENSG00000165195 E034 38.1771732 0.0005367177 1.340995e-02 3.686977e-02 X 15331874 15331992 119 - 1.533 1.393 -0.483
ENSG00000165195 E035 0.1515154 0.0435455281 1.000000e+00   X 15335355 15335371 17 - 0.061 0.000 -11.360
ENSG00000165195 E036 0.1515154 0.0435455281 1.000000e+00   X 15335372 15335429 58 - 0.061 0.000 -11.360
ENSG00000165195 E037 19.4687806 0.0009739426 1.652883e-02 4.390484e-02 X 15335501 15335554 54 - 1.266 1.059 -0.741