ENSG00000165194

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000255531 ENSG00000165194 HEK293_OSMI2_2hA HEK293_TMG_2hB PCDH19 protein_coding protein_coding 0.7730556 0.4094729 1.231682 0.01520091 0.04126642 1.565646 0.19467091 0.00000000 0.25656360 0.00000000 0.12829153 4.7364079 0.29202083 0.00000000 0.21493333 0.21493333 3.974058e-01 3.096132e-10 FALSE TRUE
ENST00000373034 ENSG00000165194 HEK293_OSMI2_2hA HEK293_TMG_2hB PCDH19 protein_coding protein_coding 0.7730556 0.4094729 1.231682 0.01520091 0.04126642 1.565646 0.03153671 0.02271002 0.04559195 0.02271002 0.01259729 0.7651432 0.05724167 0.05243333 0.03666667 -0.01576667 9.769534e-01 3.096132e-10 FALSE TRUE
ENST00000420881 ENSG00000165194 HEK293_OSMI2_2hA HEK293_TMG_2hB PCDH19 protein_coding protein_coding 0.7730556 0.4094729 1.231682 0.01520091 0.04126642 1.565646 0.20420872 0.38676283 0.11137613 0.01457824 0.11137613 -1.7087922 0.35107083 0.94756667 0.08526667 -0.86230000 1.139288e-02 3.096132e-10 FALSE TRUE
ENST00000636150 ENSG00000165194 HEK293_OSMI2_2hA HEK293_TMG_2hB PCDH19 protein_coding protein_coding 0.7730556 0.4094729 1.231682 0.01520091 0.04126642 1.565646 0.34263929 0.00000000 0.81815026 0.00000000 0.04749848 6.3718206 0.29966250 0.00000000 0.66316667 0.66316667 3.096132e-10 3.096132e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165194 E001 0.0000000       X 100291644 100291645 2 -      
ENSG00000165194 E002 0.0000000       X 100291646 100291646 1 -      
ENSG00000165194 E003 4.5336987 0.0072564856 4.663603e-10 7.337476e-09 X 100291647 100291870 224 - 0.090 1.098 5.652
ENSG00000165194 E004 46.1873012 0.0355118427 1.917056e-07 1.843556e-06 X 100291871 100296195 4325 - 1.392 1.908 1.755
ENSG00000165194 E005 8.6159528 0.0227809679 8.025638e-01 8.742392e-01 X 100296196 100296875 680 - 0.909 1.033 0.464
ENSG00000165194 E006 2.7908049 0.0092979645 3.599189e-01 5.042304e-01 X 100341903 100342072 170 - 0.452 0.673 1.015
ENSG00000165194 E007 0.4439371 0.0216757234 1.809706e-01 3.024376e-01 X 100342073 100342075 3 - 0.227 0.000 -9.895
ENSG00000165194 E008 0.5911862 0.0184663691 9.730108e-02 1.863635e-01 X 100350646 100350661 16 - 0.283 0.000 -10.271
ENSG00000165194 E009 1.2115291 0.0110816460 4.177411e-01 5.610623e-01 X 100350662 100350704 43 - 0.376 0.284 -0.576
ENSG00000165194 E010 4.6343354 0.0050593035 7.653019e-02 1.539420e-01 X 100402524 100402575 52 - 0.798 0.627 -0.706
ENSG00000165194 E011 12.3651855 0.0021348276 1.190917e-01 2.186409e-01 X 100402576 100402851 276 - 1.134 1.082 -0.186
ENSG00000165194 E012 0.8126314 0.0151180876 3.760803e-01 5.204555e-01 X 100403524 100403664 141 - 0.283 0.165 -0.988
ENSG00000165194 E013 78.2095329 0.0009844514 4.887597e-18 2.479755e-16 X 100406451 100410273 3823 - 1.941 1.769 -0.578