ENSG00000165138

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353234 ENSG00000165138 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKS6 protein_coding protein_coding 33.83924 56.48114 20.26738 0.2913046 0.8623404 -1.478153 10.5346053 16.017474 7.2996557 0.68722157 0.2097608 -1.132672 0.32200417 0.28360000 0.36140000 0.07780000 7.396550e-02 9.431412e-23 FALSE TRUE
ENST00000466120 ENSG00000165138 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKS6 protein_coding processed_transcript 33.83924 56.48114 20.26738 0.2913046 0.8623404 -1.478153 2.9667210 4.255959 1.8804541 0.52958317 1.0484635 -1.174137 0.09060833 0.07530000 0.08866667 0.01336667 9.202294e-01 9.431412e-23 FALSE FALSE
ENST00000486778 ENSG00000165138 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKS6 protein_coding processed_transcript 33.83924 56.48114 20.26738 0.2913046 0.8623404 -1.478153 12.2010295 23.400288 4.6507214 0.41912606 0.1215169 -2.328517 0.33691667 0.41426667 0.23086667 -0.18340000 5.385835e-09 9.431412e-23   FALSE
MSTRG.33136.19 ENSG00000165138 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKS6 protein_coding   33.83924 56.48114 20.26738 0.2913046 0.8623404 -1.478153 0.5373187 0.000000 1.3145337 0.00000000 0.2145786 7.049341 0.02433750 0.00000000 0.06500000 0.06500000 9.431412e-23 9.431412e-23 FALSE TRUE
MSTRG.33136.22 ENSG00000165138 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKS6 protein_coding   33.83924 56.48114 20.26738 0.2913046 0.8623404 -1.478153 2.5146486 4.991053 0.9644899 0.02468329 0.1692840 -2.359513 0.06970833 0.08836667 0.04843333 -0.03993333 5.426492e-02 9.431412e-23 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165138 E001 35.5540775 0.0018321872 6.878366e-01 7.900879e-01 9 98731329 98731995 667 - 1.479 1.512 0.113
ENSG00000165138 E002 8.1755723 0.0042056738 2.234742e-01 3.545326e-01 9 98731996 98732008 13 - 1.016 0.875 -0.526
ENSG00000165138 E003 7.3671954 0.0140514666 2.974295e-01 4.387688e-01 9 98732009 98732012 4 - 0.970 0.838 -0.502
ENSG00000165138 E004 12.1695713 0.0049859683 6.772989e-01 7.820532e-01 9 98732013 98732026 14 - 1.095 1.055 -0.144
ENSG00000165138 E005 58.2009941 0.0004074966 8.009214e-01 8.731198e-01 9 98732027 98732061 35 - 1.711 1.703 -0.028
ENSG00000165138 E006 99.2452691 0.0003318825 1.528041e-01 2.654702e-01 9 98732062 98732092 31 - 1.886 1.950 0.215
ENSG00000165138 E007 153.7342288 0.0016488302 1.644920e-04 8.113548e-04 9 98732093 98732146 54 - 2.004 2.158 0.515
ENSG00000165138 E008 149.1549972 0.0037463900 4.307798e-04 1.892732e-03 9 98732147 98732170 24 - 1.979 2.148 0.567
ENSG00000165138 E009 222.1409745 0.0020523793 2.177837e-08 2.521603e-07 9 98732171 98732246 76 - 2.116 2.326 0.703
ENSG00000165138 E010 181.4695823 0.0040130284 1.000763e-09 1.483967e-08 9 98732247 98732285 39 - 1.964 2.252 0.963
ENSG00000165138 E011 178.0903905 0.0030354784 4.225126e-11 7.938895e-10 9 98732286 98732335 50 - 1.952 2.245 0.983
ENSG00000165138 E012 118.2190411 0.0028158697 2.706864e-08 3.074569e-07 9 98732336 98732336 1 - 1.788 2.066 0.935
ENSG00000165138 E013 331.8071729 0.0009749024 1.012478e-17 4.975641e-16 9 98732337 98732553 217 - 2.258 2.506 0.827
ENSG00000165138 E014 1359.4298894 0.0002454310 2.301066e-02 5.777274e-02 9 98732554 98736001 3448 - 3.043 3.074 0.104
ENSG00000165138 E015 146.2816463 0.0022796818 7.665567e-03 2.294184e-02 9 98736002 98736281 280 - 2.172 2.073 -0.332
ENSG00000165138 E016 147.9870393 0.0004498669 4.704724e-07 4.183299e-06 9 98736282 98736495 214 - 2.219 2.061 -0.527
ENSG00000165138 E017 69.9212303 0.0008614852 1.290558e-04 6.547383e-04 9 98736496 98736526 31 - 1.909 1.737 -0.582
ENSG00000165138 E018 136.3832513 0.0002711502 1.361330e-03 5.180898e-03 9 98736527 98736623 97 - 2.144 2.042 -0.342
ENSG00000165138 E019 138.1749118 0.0002983830 3.304892e-05 1.945564e-04 9 98745559 98745675 117 - 2.171 2.039 -0.442
ENSG00000165138 E020 0.0000000       9 98746060 98746094 35 -      
ENSG00000165138 E021 112.5238896 0.0054821675 4.666498e-02 1.032314e-01 9 98751029 98751096 68 - 2.059 1.963 -0.322
ENSG00000165138 E022 162.9573129 0.0021048967 7.569482e-04 3.104266e-03 9 98756420 98756603 184 - 2.235 2.116 -0.397
ENSG00000165138 E023 23.4868288 0.0008297919 1.340961e-03 5.112928e-03 9 98756604 98756606 3 - 1.486 1.253 -0.811
ENSG00000165138 E024 119.1769621 0.0052812528 2.342620e-02 5.863653e-02 9 98768081 98768250 170 - 2.091 1.985 -0.356
ENSG00000165138 E025 119.3861439 0.0027796123 7.959134e-08 8.242232e-07 9 98770896 98771046 151 - 2.171 1.952 -0.735
ENSG00000165138 E026 141.5885540 0.0002377224 1.959265e-19 1.174982e-17 9 98773877 98774080 204 - 2.278 2.003 -0.921
ENSG00000165138 E027 85.3966477 0.0004523862 2.791135e-13 7.455896e-12 9 98777405 98777454 50 - 2.068 1.780 -0.969
ENSG00000165138 E028 142.9172047 0.0004869676 1.802193e-15 6.588576e-14 9 98778226 98778424 199 - 2.265 2.015 -0.838
ENSG00000165138 E029 108.6441068 0.0030349467 1.414664e-05 9.073499e-05 9 98780189 98780337 149 - 2.107 1.920 -0.627
ENSG00000165138 E030 25.8792943 0.0008167885 3.259820e-04 1.484812e-03 9 98781298 98781499 202 - 1.113 1.429 1.111
ENSG00000165138 E031 33.8270829 0.0050128576 2.164317e-05 1.330985e-04 9 98781500 98781645 146 - 1.177 1.548 1.288
ENSG00000165138 E032 109.0260447 0.0003044456 2.021514e-05 1.252166e-04 9 98782467 98782573 107 - 2.083 1.932 -0.508
ENSG00000165138 E033 202.0242819 0.0002114541 5.949944e-28 8.386898e-26 9 98783570 98783949 380 - 1.936 2.307 1.242
ENSG00000165138 E034 84.4694784 0.0004448082 1.774122e-09 2.510660e-08 9 98783950 98783952 3 - 1.613 1.920 1.035
ENSG00000165138 E035 340.6965066 0.0009126894 1.135615e-01 2.107221e-01 9 98783953 98784157 205 - 2.431 2.477 0.152
ENSG00000165138 E036 0.9889485 0.0398108395 5.359261e-01 6.677189e-01 9 98784380 98784468 89 - 0.182 0.304 0.964
ENSG00000165138 E037 171.2299872 0.0012655333 9.383206e-01 9.652534e-01 9 98784832 98784876 45 - 2.168 2.170 0.007
ENSG00000165138 E038 15.8440078 0.0011635834 1.996244e-01 3.257598e-01 9 98789911 98790103 193 - 1.247 1.134 -0.399
ENSG00000165138 E039 315.2309081 0.0001758690 2.451510e-02 6.088106e-02 9 98790104 98790606 503 - 2.468 2.423 -0.151
ENSG00000165138 E040 27.9499381 0.0007303837 8.691218e-06 5.856185e-05 9 98791483 98791592 110 - 1.597 1.300 -1.023
ENSG00000165138 E041 13.6190508 0.0012690123 3.200278e-05 1.890912e-04 9 98791593 98791597 5 - 1.349 0.971 -1.353
ENSG00000165138 E042 3.0539732 0.0189678802 3.233190e-08 3.617305e-07 9 98795990 98796010 21 - 1.015 0.149 -4.521
ENSG00000165138 E043 12.6170039 0.0688949530 3.203793e-04 1.462316e-03 9 98796011 98796132 122 - 1.413 0.857 -2.007
ENSG00000165138 E044 161.3039317 0.0025471658 4.257849e-05 2.439106e-04 9 98796133 98796683 551 - 2.253 2.102 -0.503
ENSG00000165138 E045 0.1482932 0.0414504205 1.000000e+00   9 98796684 98796965 282 - 0.001 0.080 7.220