ENSG00000165105

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340717 ENSG00000165105 HEK293_OSMI2_2hA HEK293_TMG_2hB RASEF protein_coding protein_coding 5.470311 1.566524 9.523101 0.07026071 0.08222143 2.596199 0.3994729 0.081466936 0.9482254 0.027091897 0.1719098 3.389043 0.07140417 0.053833333 0.0993000 0.04546667 0.403616863 0.00114049 FALSE TRUE
ENST00000376447 ENSG00000165105 HEK293_OSMI2_2hA HEK293_TMG_2hB RASEF protein_coding protein_coding 5.470311 1.566524 9.523101 0.07026071 0.08222143 2.596199 4.6368458 1.480018128 7.4249865 0.094362479 0.2505072 2.319000 0.87812083 0.943133333 0.7802333 -0.16290000 0.007137271 0.00114049 FALSE TRUE
MSTRG.32906.3 ENSG00000165105 HEK293_OSMI2_2hA HEK293_TMG_2hB RASEF protein_coding   5.470311 1.566524 9.523101 0.07026071 0.08222143 2.596199 0.4299375 0.005038789 1.1498891 0.005038789 0.1999176 6.269155 0.05005833 0.003033333 0.1205000 0.11746667 0.001140490 0.00114049 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165105 E001 339.59126 0.0026083830 1.538164e-25 1.781177e-23 9 82979590 82982513 2924 - 2.337 2.635 0.993
ENSG00000165105 E002 53.50723 0.0004530294 5.222472e-01 6.560842e-01 9 82982514 82982782 269 - 1.602 1.612 0.033
ENSG00000165105 E003 33.00820 0.0023236247 3.728154e-01 5.172374e-01 9 82990391 82990467 77 - 1.403 1.377 -0.091
ENSG00000165105 E004 42.33927 0.0047490783 7.086925e-02 1.447903e-01 9 82992906 82993025 120 - 1.518 1.420 -0.337
ENSG00000165105 E005 39.30264 0.0005409076 1.788825e-01 2.997360e-01 9 82997012 82997126 115 - 1.485 1.432 -0.180
ENSG00000165105 E006 30.95018 0.0006814527 2.192123e-01 3.494187e-01 9 82998365 82998446 82 - 1.385 1.330 -0.193
ENSG00000165105 E007 41.97375 0.0051823481 6.546295e-01 7.647554e-01 9 83000169 83000316 148 - 1.486 1.568 0.278
ENSG00000165105 E008 41.73552 0.0022311050 3.727144e-01 5.171313e-01 9 83000433 83000570 138 - 1.501 1.482 -0.064
ENSG00000165105 E009 56.34919 0.0004946346 1.129134e-02 3.185522e-02 9 83000896 83001130 235 - 1.644 1.526 -0.402
ENSG00000165105 E010 29.67240 0.0008691653 4.303626e-01 5.730112e-01 9 83004498 83004586 89 - 1.364 1.346 -0.062
ENSG00000165105 E011 34.22440 0.0007413857 9.770438e-02 1.869941e-01 9 83005416 83005500 85 - 1.434 1.346 -0.304
ENSG00000165105 E012 27.89598 0.0009448572 4.738721e-02 1.045217e-01 9 83007437 83007505 69 - 1.354 1.217 -0.481
ENSG00000165105 E013 37.44438 0.0006401663 5.605170e-04 2.386682e-03 9 83009641 83009756 116 - 1.488 1.238 -0.871
ENSG00000165105 E014 28.64487 0.0006954932 3.636519e-04 1.633343e-03 9 83012434 83012511 78 - 1.381 1.064 -1.120
ENSG00000165105 E015 32.74649 0.0006228047 1.104781e-01 2.062376e-01 9 83015805 83015900 96 - 1.414 1.330 -0.295
ENSG00000165105 E016 37.53632 0.0007389925 2.428398e-02 6.040054e-02 9 83022336 83022426 91 - 1.479 1.346 -0.461
ENSG00000165105 E017 35.23589 0.0006236135 2.170722e-05 1.334491e-04 9 83025775 83025916 142 - 1.473 1.121 -1.235
ENSG00000165105 E018 12.49953 0.0026764002 8.344613e-05 4.443119e-04 9 83025917 83025921 5 - 1.067 0.420 -2.711
ENSG00000165105 E019 10.44827 0.0016723083 3.835663e-01 5.277777e-01 9 83054660 83055683 1024 - 0.951 0.876 -0.284
ENSG00000165105 E020 53.09942 0.0021542877 9.866807e-08 1.002917e-06 9 83062437 83063177 741 - 1.648 1.258 -1.344