ENSG00000165097

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000449850 ENSG00000165097 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM1B protein_coding protein_coding 10.44141 4.948703 15.48169 0.3897742 0.2422791 1.643459 0.8938271 0.3677622 1.437478 0.03055941 0.3485769 1.937991 0.07823750 0.07603333 0.09306667 0.01703333 8.373799e-01 1.477599e-17 FALSE TRUE
ENST00000546309 ENSG00000165097 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM1B protein_coding protein_coding 10.44141 4.948703 15.48169 0.3897742 0.2422791 1.643459 0.2993390 0.7216606 0.000000 0.38549522 0.0000000 -6.193103 0.05656250 0.13676667 0.00000000 -0.13676667 5.598627e-02 1.477599e-17 FALSE TRUE
ENST00000650836 ENSG00000165097 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM1B protein_coding protein_coding 10.44141 4.948703 15.48169 0.3897742 0.2422791 1.643459 5.5775935 1.1521562 10.548150 0.67392099 0.3791430 3.183481 0.44057917 0.24173333 0.68156667 0.43983333 2.626043e-01 1.477599e-17 FALSE TRUE
MSTRG.27699.2 ENSG00000165097 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM1B protein_coding   10.44141 4.948703 15.48169 0.3897742 0.2422791 1.643459 1.1680794 0.2587165 2.609903 0.13256703 0.3294909 3.285357 0.08812917 0.05693333 0.16803333 0.11110000 3.457223e-01 1.477599e-17 FALSE TRUE
MSTRG.27699.5 ENSG00000165097 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM1B protein_coding   10.44141 4.948703 15.48169 0.3897742 0.2422791 1.643459 1.0382375 0.5607602 0.000000 0.28393965 0.0000000 -5.834813 0.13320417 0.10946667 0.00000000 -0.10946667 5.064827e-02 1.477599e-17 FALSE TRUE
MSTRG.27699.7 ENSG00000165097 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM1B protein_coding   10.44141 4.948703 15.48169 0.3897742 0.2422791 1.643459 0.8168206 1.6789087 0.000000 0.36234152 0.0000000 -7.399948 0.13805000 0.33726667 0.00000000 -0.33726667 1.477599e-17 1.477599e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165097 E001 0.7394793 0.0157475575 8.712957e-01 9.212209e-01 6 18155329 18155404 76 + 0.236 0.201 -0.294
ENSG00000165097 E002 1.0684327 0.0122757698 7.608251e-01 8.448166e-01 6 18155405 18155413 9 + 0.279 0.338 0.385
ENSG00000165097 E003 1.3671972 0.0125606848 9.267987e-01 9.579209e-01 6 18155414 18155421 8 + 0.354 0.338 -0.100
ENSG00000165097 E004 2.1141652 0.0080862289 3.942851e-01 5.381411e-01 6 18155422 18155443 22 + 0.500 0.338 -0.878
ENSG00000165097 E005 3.4437865 0.0174189295 7.311484e-02 1.485053e-01 6 18155444 18155451 8 + 0.680 0.338 -1.686
ENSG00000165097 E006 18.0851357 0.0010844048 1.066988e-03 4.190858e-03 6 18155452 18155571 120 + 1.303 0.965 -1.213
ENSG00000165097 E007 19.0363790 0.0010105127 4.040389e-02 9.176061e-02 6 18155883 18155926 44 + 1.299 1.106 -0.685
ENSG00000165097 E008 0.4783925 0.0221614905 6.835063e-01 7.866937e-01 6 18156278 18156377 100 + 0.134 0.201 0.708
ENSG00000165097 E009 52.9755923 0.0004646543 5.182671e-04 2.228419e-03 6 18159883 18159982 100 + 1.728 1.523 -0.696
ENSG00000165097 E010 75.4495161 0.0012445853 1.420856e-01 2.508756e-01 6 18161327 18161454 128 + 1.852 1.781 -0.238
ENSG00000165097 E011 56.8199563 0.0003880581 8.511631e-01 9.077160e-01 6 18162835 18162924 90 + 1.716 1.707 -0.028
ENSG00000165097 E012 71.6774991 0.0003768489 5.562540e-01 6.849305e-01 6 18166267 18166378 112 + 1.820 1.793 -0.088
ENSG00000165097 E013 76.6027947 0.0022088543 5.948651e-02 1.257467e-01 6 18171363 18171479 117 + 1.866 1.771 -0.318
ENSG00000165097 E014 43.5028348 0.0010134590 4.409672e-02 9.856053e-02 6 18185772 18185810 39 + 1.633 1.507 -0.430
ENSG00000165097 E015 72.2190292 0.0007764095 2.887835e-01 4.294182e-01 6 18187792 18188002 211 + 1.830 1.781 -0.166
ENSG00000165097 E016 81.8276638 0.0003460275 9.400277e-03 2.728150e-02 6 18191197 18191381 185 + 1.898 1.781 -0.396
ENSG00000165097 E017 114.6246038 0.0002695846 3.688863e-04 1.653755e-03 6 18197057 18197233 177 + 2.046 1.908 -0.462
ENSG00000165097 E018 72.3156481 0.0004526798 1.390400e-01 2.467629e-01 6 18197587 18197661 75 + 1.833 1.764 -0.235
ENSG00000165097 E019 90.6532622 0.0006341818 5.274989e-01 6.605514e-01 6 18200439 18200576 138 + 1.920 1.895 -0.085
ENSG00000165097 E020 89.4334104 0.0003230632 6.536790e-01 7.640889e-01 6 18201486 18201657 172 + 1.900 1.921 0.069
ENSG00000165097 E021 89.0617932 0.0015102892 8.650008e-01 9.170116e-01 6 18205537 18205664 128 + 1.906 1.899 -0.024
ENSG00000165097 E022 87.2854000 0.0004028626 1.262378e-01 2.289144e-01 6 18207398 18207529 132 + 1.910 1.844 -0.222
ENSG00000165097 E023 3.1170337 0.0152921854 7.194561e-01 8.142833e-01 6 18208129 18208131 3 + 0.589 0.526 -0.292
ENSG00000165097 E024 62.3605062 0.0004004402 2.752273e-01 4.144983e-01 6 18208132 18208206 75 + 1.767 1.712 -0.184
ENSG00000165097 E025 2.2937932 0.0064371576 7.464299e-01 8.342042e-01 6 18211495 18212487 993 + 0.500 0.442 -0.293
ENSG00000165097 E026 83.3397042 0.0007290112 8.130820e-01 8.814797e-01 6 18212488 18212604 117 + 1.878 1.869 -0.032
ENSG00000165097 E027 79.4420038 0.0019407368 5.221498e-01 6.559967e-01 6 18213656 18213781 126 + 1.861 1.830 -0.107
ENSG00000165097 E028 66.4760052 0.0004283161 7.720666e-01 8.528886e-01 6 18215007 18215129 123 + 1.781 1.768 -0.043
ENSG00000165097 E029 86.7615651 0.0003598349 2.653946e-01 4.034489e-01 6 18217733 18217880 148 + 1.905 1.858 -0.158
ENSG00000165097 E030 42.5379208 0.0072755602 3.906579e-01 5.346233e-01 6 18217881 18217885 5 + 1.604 1.539 -0.223
ENSG00000165097 E031 465.3428557 0.0001806376 7.515077e-32 1.425134e-29 6 18221909 18223854 1946 + 2.560 2.749 0.632