ENSG00000164985

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380733 ENSG00000164985 HEK293_OSMI2_2hA HEK293_TMG_2hB PSIP1 protein_coding protein_coding 60.22164 36.27624 99.715 2.834753 5.677406 1.458533 7.550537 3.474149 20.721370 3.4741487 0.7970160 2.57293738 0.10425833 0.09593333 0.20830000 0.1123666667 1.385418e-01 7.568639e-25 FALSE  
ENST00000380738 ENSG00000164985 HEK293_OSMI2_2hA HEK293_TMG_2hB PSIP1 protein_coding protein_coding 60.22164 36.27624 99.715 2.834753 5.677406 1.458533 18.605647 7.609707 26.604425 3.8611482 0.8515158 1.80440096 0.30408750 0.21063333 0.26770000 0.0570666667 8.519768e-01 7.568639e-25 FALSE  
ENST00000397519 ENSG00000164985 HEK293_OSMI2_2hA HEK293_TMG_2hB PSIP1 protein_coding protein_coding 60.22164 36.27624 99.715 2.834753 5.677406 1.458533 17.282583 12.290964 24.678453 0.5873444 1.3148648 1.00506504 0.29936667 0.34110000 0.24766667 -0.0934333333 2.626278e-03 7.568639e-25 FALSE  
ENST00000481862 ENSG00000164985 HEK293_OSMI2_2hA HEK293_TMG_2hB PSIP1 protein_coding protein_coding 60.22164 36.27624 99.715 2.834753 5.677406 1.458533 5.879711 4.502758 11.911274 2.2727238 2.2049114 1.40145725 0.09457083 0.11740000 0.11766667 0.0002666667 8.996559e-01 7.568639e-25    
ENST00000488797 ENSG00000164985 HEK293_OSMI2_2hA HEK293_TMG_2hB PSIP1 protein_coding processed_transcript 60.22164 36.27624 99.715 2.834753 5.677406 1.458533 2.124814 3.706514 1.512597 0.3844820 0.1526640 -1.28741531 0.05687917 0.10470000 0.01530000 -0.0894000000 2.042830e-10 7.568639e-25    
MSTRG.32427.3 ENSG00000164985 HEK293_OSMI2_2hA HEK293_TMG_2hB PSIP1 protein_coding   60.22164 36.27624 99.715 2.834753 5.677406 1.458533 2.355940 0.000000 6.330694 0.0000000 0.6418972 9.30849683 0.02610000 0.00000000 0.06373333 0.0637333333 7.568639e-25 7.568639e-25 TRUE  
MSTRG.32427.8 ENSG00000164985 HEK293_OSMI2_2hA HEK293_TMG_2hB PSIP1 protein_coding   60.22164 36.27624 99.715 2.834753 5.677406 1.458533 3.805376 3.869588 3.747260 0.3788066 0.8021536 -0.04622239 0.07337917 0.10760000 0.03690000 -0.0707000000 5.667717e-04 7.568639e-25 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164985 E001 960.879106 2.710461e-03 5.650812e-01 6.922451e-01 9 15464066 15465555 1490 - 2.926 2.964 0.127
ENSG00000164985 E002 167.173404 3.017503e-03 1.533759e-04 7.620405e-04 9 15465556 15465580 25 - 2.211 2.074 -0.461
ENSG00000164985 E003 266.664375 1.124849e-03 3.021909e-06 2.259330e-05 9 15466748 15466859 112 - 2.409 2.290 -0.396
ENSG00000164985 E004 355.122637 4.543403e-04 1.844941e-13 5.056691e-12 9 15468630 15468819 190 - 2.542 2.384 -0.527
ENSG00000164985 E005 199.247663 2.090074e-04 2.254156e-13 6.098873e-12 9 15468820 15468843 24 - 2.302 2.096 -0.691
ENSG00000164985 E006 244.681708 1.254993e-03 1.256146e-09 1.826629e-08 9 15468957 15469058 102 - 2.385 2.210 -0.583
ENSG00000164985 E007 204.232560 2.205350e-04 9.895958e-09 1.221580e-07 9 15469266 15469336 71 - 2.302 2.150 -0.506
ENSG00000164985 E008 221.060351 3.065917e-04 1.845916e-09 2.603508e-08 9 15469938 15469993 56 - 2.337 2.181 -0.521
ENSG00000164985 E009 1.988483 6.050811e-02 5.556424e-02 1.189459e-01 9 15470636 15470645 10 - 0.324 0.695 1.832
ENSG00000164985 E010 15.330240 9.706500e-03 5.553696e-06 3.912598e-05 9 15470646 15470684 39 - 0.995 1.452 1.622
ENSG00000164985 E011 66.005939 1.632454e-02 3.577070e-11 6.797725e-10 9 15470685 15470801 117 - 1.563 2.089 1.776
ENSG00000164985 E012 180.276360 8.144190e-03 1.160948e-18 6.360267e-17 9 15470802 15470989 188 - 2.021 2.495 1.584
ENSG00000164985 E013 263.464712 2.675673e-03 8.419036e-30 1.390550e-27 9 15470990 15471176 187 - 2.225 2.619 1.314
ENSG00000164985 E014 101.572626 1.738094e-03 5.691780e-15 1.942516e-13 9 15471177 15471231 55 - 1.839 2.178 1.135
ENSG00000164985 E015 12.081980 1.390503e-03 8.933869e-01 9.358555e-01 9 15471232 15471311 80 - 1.062 1.095 0.118
ENSG00000164985 E016 20.125519 9.167454e-04 3.207568e-01 4.639225e-01 9 15472081 15472631 551 - 1.298 1.231 -0.236
ENSG00000164985 E017 536.349313 2.156540e-04 1.418624e-09 2.044690e-08 9 15472632 15472750 119 - 2.643 2.768 0.415
ENSG00000164985 E018 693.282007 9.804985e-05 4.116187e-02 9.318267e-02 9 15474009 15474237 229 - 2.779 2.829 0.168
ENSG00000164985 E019 398.644983 1.707671e-04 2.274844e-01 3.594025e-01 9 15478477 15478552 76 - 2.541 2.586 0.148
ENSG00000164985 E020 466.088487 2.044430e-04 9.956050e-01 1.000000e+00 9 15479591 15479687 97 - 2.616 2.636 0.068
ENSG00000164985 E021 1.817576 2.178279e-02 8.827343e-01 9.289607e-01 9 15485903 15486005 103 - 0.395 0.435 0.218
ENSG00000164985 E022 411.087791 3.294399e-04 1.266957e-01 2.295448e-01 9 15486006 15486068 63 - 2.570 2.558 -0.039
ENSG00000164985 E023 466.284764 1.771648e-03 3.170404e-02 7.527270e-02 9 15486827 15486931 105 - 2.631 2.595 -0.121
ENSG00000164985 E024 2.552906 5.821744e-03 3.625047e-02 8.406115e-02 9 15489270 15489440 171 - 0.598 0.197 -2.370
ENSG00000164985 E025 449.222283 1.095031e-03 2.740068e-07 2.555621e-06 9 15489986 15490124 139 - 2.632 2.526 -0.353
ENSG00000164985 E026 43.494630 1.674491e-02 1.556695e-28 2.303994e-26 9 15491952 15492225 274 - 1.076 2.055 3.365
ENSG00000164985 E027 1.492790 4.418709e-02 2.416130e-01 3.760783e-01 9 15504959 15506560 1602 - 0.426 0.196 -1.546
ENSG00000164985 E028 305.435972 1.520571e-04 1.477116e-04 7.372623e-04 9 15506561 15506637 77 - 2.457 2.388 -0.231
ENSG00000164985 E029 263.955497 1.483525e-04 3.091109e-07 2.852279e-06 9 15510117 15510326 210 - 2.404 2.293 -0.371
ENSG00000164985 E030 17.724445 2.614105e-03 1.365127e-06 1.101128e-05 9 15510327 15510329 3 - 1.326 0.789 -1.969
ENSG00000164985 E031 54.312133 4.944857e-04 5.797547e-13 1.477637e-11 9 15510817 15511025 209 - 1.784 1.335 -1.536
ENSG00000164985 E032 1.369387 9.718036e-03 8.310021e-01 8.940516e-01 9 15511026 15511381 356 - 0.361 0.331 -0.179