ENSG00000164961

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318410 ENSG00000164961 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC5 protein_coding protein_coding 20.25694 8.26706 31.38009 0.6284754 0.7075532 1.923119 6.8320655 1.8519257 10.8931938 0.5301758 0.42358957 2.54988337 0.32640417 0.23626667 0.347233333 0.1109667 4.631950e-01 5.629341e-21 FALSE TRUE
ENST00000517845 ENSG00000164961 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC5 protein_coding protein_coding 20.25694 8.26706 31.38009 0.6284754 0.7075532 1.923119 1.5380272 3.0757038 3.1932793 0.3942600 0.55305052 0.05394999 0.14660833 0.36930000 0.101233333 -0.2680667 2.532923e-08 5.629341e-21 FALSE TRUE
ENST00000519042 ENSG00000164961 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC5 protein_coding retained_intron 20.25694 8.26706 31.38009 0.6284754 0.7075532 1.923119 0.4666023 0.9624508 0.1713735 0.6791362 0.08734169 -2.42266140 0.05882917 0.10896667 0.005366667 -0.1036000 7.199650e-02 5.629341e-21 FALSE TRUE
ENST00000523297 ENSG00000164961 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC5 protein_coding protein_coding 20.25694 8.26706 31.38009 0.6284754 0.7075532 1.923119 1.9432131 0.0000000 4.6904399 0.0000000 0.44489220 8.87665197 0.06692083 0.00000000 0.149033333 0.1490333 5.629341e-21 5.629341e-21 FALSE FALSE
ENST00000530856 ENSG00000164961 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC5 protein_coding retained_intron 20.25694 8.26706 31.38009 0.6284754 0.7075532 1.923119 2.6551224 0.7035626 2.3222797 0.7035626 1.16207265 1.70862883 0.10015833 0.08046667 0.072566667 -0.0079000 6.780751e-01 5.629341e-21 FALSE FALSE
MSTRG.32069.6 ENSG00000164961 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC5 protein_coding   20.25694 8.26706 31.38009 0.6284754 0.7075532 1.923119 6.6484238 1.4181998 9.8673096 0.2842212 2.00095658 2.78992028 0.28903750 0.17353333 0.316800000 0.1432667 2.854692e-01 5.629341e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164961 E001 1.3767742 0.0383162381 5.102752e-01 6.455174e-01 8 125023613 125024259 647 - 0.309 0.452 0.823
ENSG00000164961 E002 0.9264943 0.0142420326 1.579932e-01 2.724623e-01 8 125024260 125024266 7 - 0.181 0.453 1.828
ENSG00000164961 E003 11.2196142 0.0018897093 1.667773e-07 1.623527e-06 8 125024267 125024299 33 - 0.814 1.363 2.000
ENSG00000164961 E004 163.3353284 0.0102337563 2.995136e-09 4.063446e-08 8 125024300 125024673 374 - 2.035 2.395 1.203
ENSG00000164961 E005 158.3825997 0.0031945339 1.188357e-11 2.443353e-10 8 125028620 125028707 88 - 2.049 2.345 0.988
ENSG00000164961 E006 184.7078226 0.0082343829 6.975687e-08 7.300426e-07 8 125032241 125032394 154 - 2.111 2.414 1.012
ENSG00000164961 E007 2.4754845 0.0058816312 8.592988e-01 9.132255e-01 8 125032395 125032714 320 - 0.487 0.538 0.245
ENSG00000164961 E008 130.4184915 0.0071140736 1.280731e-06 1.039548e-05 8 125037237 125037333 97 - 1.971 2.251 0.938
ENSG00000164961 E009 126.3606865 0.0010548159 1.197974e-09 1.748748e-08 8 125038830 125038959 130 - 1.971 2.218 0.828
ENSG00000164961 E010 106.1153426 0.0002874576 1.571755e-06 1.250533e-05 8 125039795 125039898 104 - 1.910 2.115 0.690
ENSG00000164961 E011 102.6115239 0.0002837463 7.902665e-05 4.232666e-04 8 125043825 125043904 80 - 1.906 2.084 0.596
ENSG00000164961 E012 109.7734008 0.0017313406 3.634310e-04 1.632428e-03 8 125043992 125044094 103 - 1.936 2.111 0.584
ENSG00000164961 E013 0.7469680 0.0181507943 2.256640e-01 3.571732e-01 8 125044486 125044535 50 - 0.270 0.000 -9.742
ENSG00000164961 E014 159.3415713 0.0004026018 1.423268e-01 2.512147e-01 8 125044536 125044698 163 - 2.126 2.201 0.251
ENSG00000164961 E015 141.2663807 0.0005633240 3.954435e-01 5.392520e-01 8 125047207 125047331 125 - 2.078 2.136 0.192
ENSG00000164961 E016 166.9896639 0.0005640953 1.902601e-01 3.141052e-01 8 125049006 125049185 180 - 2.147 2.217 0.234
ENSG00000164961 E017 111.9676736 0.0007230461 4.907188e-01 6.280598e-01 8 125050564 125050665 102 - 1.993 1.994 0.001
ENSG00000164961 E018 113.8970599 0.0002664471 1.569690e-02 4.205710e-02 8 125055591 125055671 81 - 2.016 1.948 -0.226
ENSG00000164961 E019 141.9192737 0.0037372076 9.067304e-02 1.761855e-01 8 125056677 125056817 141 - 2.108 2.055 -0.177
ENSG00000164961 E020 124.3676376 0.0042520158 6.022794e-02 1.269951e-01 8 125057556 125057666 111 - 2.054 1.986 -0.228
ENSG00000164961 E021 99.4870728 0.0003207008 2.362578e-02 5.904013e-02 8 125059222 125059297 76 - 1.961 1.894 -0.226
ENSG00000164961 E022 120.9779973 0.0003531134 6.415539e-02 1.336197e-01 8 125059376 125059542 167 - 2.037 1.994 -0.144
ENSG00000164961 E023 90.4570936 0.0189679137 8.511953e-01 9.077299e-01 8 125061082 125061194 113 - 1.896 1.910 0.046
ENSG00000164961 E024 114.5131292 0.0002984160 1.699537e-03 6.282015e-03 8 125063522 125063651 130 - 2.024 1.927 -0.327
ENSG00000164961 E025 131.7388453 0.0005396598 5.112460e-07 4.513865e-06 8 125067592 125067719 128 - 2.100 1.930 -0.569
ENSG00000164961 E026 122.2185765 0.0016108322 5.471863e-07 4.803429e-06 8 125073153 125073324 172 - 2.072 1.877 -0.657
ENSG00000164961 E027 55.2043634 0.0019115995 2.859210e-03 9.850672e-03 8 125074998 125075040 43 - 1.727 1.570 -0.531
ENSG00000164961 E028 65.9685876 0.0038941736 4.271097e-04 1.878634e-03 8 125075041 125075111 71 - 1.810 1.617 -0.651
ENSG00000164961 E029 112.0013905 0.0003293726 3.076349e-08 3.454069e-07 8 125076348 125076500 153 - 2.038 1.832 -0.694
ENSG00000164961 E030 140.1203333 0.0022231267 1.430816e-12 3.415622e-11 8 125078738 125078930 193 - 2.148 1.854 -0.985
ENSG00000164961 E031 100.6110086 0.0061627792 3.789451e-07 3.432466e-06 8 125081661 125081761 101 - 2.003 1.725 -0.936
ENSG00000164961 E032 60.3985976 0.0006735643 1.244861e-06 1.013212e-05 8 125082383 125082421 39 - 1.783 1.525 -0.877
ENSG00000164961 E033 42.8138086 0.0141903799 1.624296e-03 6.038541e-03 8 125082422 125082432 11 - 1.638 1.382 -0.877
ENSG00000164961 E034 56.3698178 0.0031012188 1.968144e-05 1.222890e-04 8 125082433 125082467 35 - 1.754 1.500 -0.863
ENSG00000164961 E035 0.0000000       8 125082886 125083112 227 -      
ENSG00000164961 E036 93.9030398 0.0004008925 2.402856e-08 2.757367e-07 8 125083113 125083258 146 - 1.965 1.731 -0.790
ENSG00000164961 E037 38.3872544 0.0007132906 9.396262e-06 6.284976e-05 8 125083713 125083776 64 - 1.593 1.288 -1.050
ENSG00000164961 E038 42.3735449 0.0005139457 4.081427e-03 1.337139e-02 8 125083777 125083834 58 - 1.611 1.447 -0.562
ENSG00000164961 E039 58.6229195 0.0003841065 5.823687e-05 3.227853e-04 8 125083835 125084022 188 - 1.760 1.556 -0.694
ENSG00000164961 E040 0.4482035 0.0278693252 4.964579e-01 6.331031e-01 8 125091003 125091045 43 - 0.181 0.000 -9.005
ENSG00000164961 E041 42.6102747 0.0054254000 4.357862e-04 1.912092e-03 8 125091615 125091819 205 - 1.631 1.386 -0.841