ENSG00000164944

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000522196 ENSG00000164944 HEK293_OSMI2_2hA HEK293_TMG_2hB VIRMA protein_coding retained_intron 20.60057 10.25215 31.45223 1.631396 0.150443 1.616288 5.1524194 5.5335681 5.809665 1.7056207 0.8456385 0.07012121 0.33510417 0.52523333 0.1845000 -0.34073333 0.00476719 4.868065e-05   TRUE
ENST00000523263 ENSG00000164944 HEK293_OSMI2_2hA HEK293_TMG_2hB VIRMA protein_coding nonsense_mediated_decay 20.60057 10.25215 31.45223 1.631396 0.150443 1.616288 0.5158897 0.5532674 0.000000 0.5532674 0.0000000 -5.81574801 0.03673333 0.05533333 0.0000000 -0.05533333 0.65135113 4.868065e-05 TRUE TRUE
MSTRG.31824.4 ENSG00000164944 HEK293_OSMI2_2hA HEK293_TMG_2hB VIRMA protein_coding   20.60057 10.25215 31.45223 1.631396 0.150443 1.616288 4.4586545 0.6310945 7.941534 0.3265586 0.6061306 3.63262423 0.18014583 0.07173333 0.2527000 0.18096667 0.36579086 4.868065e-05 FALSE TRUE
MSTRG.31824.7 ENSG00000164944 HEK293_OSMI2_2hA HEK293_TMG_2hB VIRMA protein_coding   20.60057 10.25215 31.45223 1.631396 0.150443 1.616288 2.7813841 0.6953389 3.733766 0.3750939 0.3744439 2.40810188 0.11310000 0.05913333 0.1186333 0.05950000 0.54779365 4.868065e-05 FALSE TRUE
MSTRG.31824.8 ENSG00000164944 HEK293_OSMI2_2hA HEK293_TMG_2hB VIRMA protein_coding   20.60057 10.25215 31.45223 1.631396 0.150443 1.616288 5.2353528 2.0532611 10.407858 0.3261081 0.7184273 2.33606044 0.23597500 0.20820000 0.3310000 0.12280000 0.14289093 4.868065e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164944 E001 8.1900051 0.0021319410 4.397477e-02 9.833322e-02 8 94487689 94488519 831 - 0.812 1.069 0.968
ENSG00000164944 E002 1.3349439 0.1760459170 3.875557e-01 5.316913e-01 8 94488520 94488520 1 - 0.276 0.490 1.231
ENSG00000164944 E003 5.7988990 0.0028896469 3.659983e-02 8.471263e-02 8 94488521 94488551 31 - 0.686 0.981 1.154
ENSG00000164944 E004 28.6417587 0.0111902177 2.952942e-07 2.736517e-06 8 94488552 94488595 44 - 1.253 1.692 1.514
ENSG00000164944 E005 52.1956086 0.0051377044 2.538420e-08 2.899410e-07 8 94488596 94488614 19 - 1.538 1.894 1.208
ENSG00000164944 E006 173.1642980 0.0066724969 5.858853e-10 9.075570e-09 8 94488615 94488860 246 - 2.066 2.376 1.036
ENSG00000164944 E007 149.6389081 0.0030358863 3.391988e-14 1.031961e-12 8 94489939 94490082 144 - 2.002 2.316 1.049
ENSG00000164944 E008 0.4439371 0.0215675828 7.915747e-01 8.666889e-01 8 94490083 94490172 90 - 0.160 0.000 -9.940
ENSG00000164944 E009 144.9590537 0.0083815242 3.592482e-07 3.270314e-06 8 94491578 94491737 160 - 1.997 2.282 0.952
ENSG00000164944 E010 165.1070505 0.0002163797 2.482660e-17 1.149676e-15 8 94491738 94491909 172 - 2.058 2.327 0.900
ENSG00000164944 E011 147.0443455 0.0002343703 4.653908e-10 7.324049e-09 8 94492652 94492818 167 - 2.025 2.240 0.721
ENSG00000164944 E012 95.1259830 0.0007199158 1.731110e-06 1.365392e-05 8 94494860 94494956 97 - 1.840 2.051 0.709
ENSG00000164944 E013 134.2496225 0.0002838901 1.015584e-04 5.290640e-04 8 94495731 94495891 161 - 2.006 2.154 0.494
ENSG00000164944 E014 6.8751005 0.0023793007 2.443357e-01 3.792847e-01 8 94495892 94496327 436 - 0.840 0.660 -0.729
ENSG00000164944 E015 139.2257208 0.0002549796 2.547238e-01 3.914902e-01 8 94496328 94496480 153 - 2.044 2.093 0.165
ENSG00000164944 E016 4.7756971 0.0048571868 2.306022e-01 3.631706e-01 8 94496481 94499373 2893 - 0.712 0.498 -0.951
ENSG00000164944 E017 111.0252821 0.0003692113 5.732520e-01 6.992163e-01 8 94499374 94499506 133 - 1.949 1.979 0.103
ENSG00000164944 E018 139.2593343 0.0002579464 2.071778e-01 3.351396e-01 8 94506500 94506717 218 - 2.042 2.096 0.179
ENSG00000164944 E019 84.7248564 0.0010983157 5.631520e-01 6.906537e-01 8 94509688 94509756 69 - 1.833 1.868 0.118
ENSG00000164944 E020 122.9417935 0.0067506166 5.949261e-01 7.170840e-01 8 94509757 94509940 184 - 2.005 1.984 -0.071
ENSG00000164944 E021 137.8903239 0.0003867476 7.853358e-01 8.623917e-01 8 94510417 94510652 236 - 2.051 2.048 -0.011
ENSG00000164944 E022 11.2873067 0.0229490860 2.896450e-01 4.303581e-01 8 94510733 94511184 452 - 0.975 1.117 0.521
ENSG00000164944 E023 231.6259436 0.0001829202 6.794666e-01 7.836317e-01 8 94511185 94511729 545 - 2.273 2.268 -0.018
ENSG00000164944 E024 92.8243408 0.0047939427 6.154275e-01 7.336959e-01 8 94511996 94512089 94 - 1.883 1.859 -0.080
ENSG00000164944 E025 1.1802960 0.0107350556 1.711019e-01 2.896105e-01 8 94512090 94512455 366 - 0.339 0.000 -11.355
ENSG00000164944 E026 71.1188647 0.0003632407 6.896441e-01 7.914932e-01 8 94514869 94514951 83 - 1.768 1.754 -0.048
ENSG00000164944 E027 89.5093661 0.0023661439 1.238682e-02 3.446288e-02 8 94517788 94517942 155 - 1.886 1.753 -0.448
ENSG00000164944 E028 222.8477429 0.0003716479 4.909022e-09 6.417773e-08 8 94518985 94519476 492 - 2.286 2.096 -0.635
ENSG00000164944 E029 432.2082284 0.0047500689 1.092157e-11 2.261019e-10 8 94526223 94527363 1141 - 2.583 2.310 -0.910
ENSG00000164944 E030 63.1787767 0.0083002049 2.067430e-04 9.928726e-04 8 94529070 94529075 6 - 1.759 1.470 -0.985
ENSG00000164944 E031 139.3187886 0.0002286476 5.140800e-22 4.105857e-20 8 94529076 94529216 141 - 2.113 1.656 -1.537
ENSG00000164944 E032 100.6457308 0.0004687601 3.091696e-15 1.097456e-13 8 94529217 94529342 126 - 1.970 1.530 -1.489
ENSG00000164944 E033 73.2200176 0.0003815277 2.934468e-09 3.989423e-08 8 94530963 94531085 123 - 1.828 1.461 -1.248
ENSG00000164944 E034 63.5657029 0.0015548831 4.388129e-08 4.785606e-07 8 94534839 94535007 169 - 1.769 1.391 -1.292
ENSG00000164944 E035 45.6850039 0.0005315755 2.112057e-10 3.522208e-09 8 94537103 94537151 49 - 1.642 1.095 -1.904
ENSG00000164944 E036 57.2744797 0.0004202329 5.539967e-10 8.613296e-09 8 94538260 94538346 87 - 1.730 1.276 -1.561
ENSG00000164944 E037 71.5047748 0.0003890696 9.677709e-12 2.022072e-10 8 94543827 94543942 116 - 1.825 1.378 -1.524
ENSG00000164944 E038 1.0457324 0.0209236757 2.238277e-01 3.549894e-01 8 94548151 94548205 55 - 0.309 0.000 -11.163
ENSG00000164944 E039 41.8215727 0.0006133158 1.396192e-05 8.970505e-05 8 94553385 94553529 145 - 1.589 1.242 -1.200