ENSG00000164941

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000517918 ENSG00000164941 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS8 protein_coding processed_transcript 42.38241 12.4923 54.426 0.7778739 0.6753242 2.122367 7.5416714 1.6976625 10.787639 0.8769460 0.5766573 2.6606212 0.17719167 0.13493333 0.19823333 0.0633000000 7.694636e-01 3.223812e-16 FALSE  
ENST00000520315 ENSG00000164941 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS8 protein_coding nonsense_mediated_decay 42.38241 12.4923 54.426 0.7778739 0.6753242 2.122367 2.4956400 0.0000000 3.991379 0.0000000 0.3540535 8.6443534 0.03852083 0.00000000 0.07340000 0.0734000000 3.223812e-16 3.223812e-16 TRUE  
ENST00000520853 ENSG00000164941 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS8 protein_coding retained_intron 42.38241 12.4923 54.426 0.7778739 0.6753242 2.122367 2.3565330 0.6159984 1.159258 0.1770042 0.3937262 0.9013624 0.05331667 0.04940000 0.02136667 -0.0280333333 4.024879e-01 3.223812e-16    
ENST00000521155 ENSG00000164941 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS8 protein_coding retained_intron 42.38241 12.4923 54.426 0.7778739 0.6753242 2.122367 7.5438742 4.0878049 10.818305 0.9318610 0.8791870 1.4018842 0.21253333 0.32600000 0.19843333 -0.1275666667 2.847874e-01 3.223812e-16    
ENST00000523321 ENSG00000164941 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS8 protein_coding retained_intron 42.38241 12.4923 54.426 0.7778739 0.6753242 2.122367 3.5251094 0.1821719 5.684578 0.1684138 0.2702829 4.8891197 0.06237500 0.01620000 0.10443333 0.0882333333 4.804594e-02 3.223812e-16 FALSE  
ENST00000523731 ENSG00000164941 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS8 protein_coding protein_coding 42.38241 12.4923 54.426 0.7778739 0.6753242 2.122367 9.2595883 2.7591996 12.084232 0.1012916 0.6976471 2.1267783 0.22840000 0.22173333 0.22240000 0.0006666667 1.000000e+00 3.223812e-16 FALSE  
MSTRG.31845.3 ENSG00000164941 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS8 protein_coding   42.38241 12.4923 54.426 0.7778739 0.6753242 2.122367 0.8771638 0.8178494 0.000000 0.4140470 0.0000000 -6.3712964 0.01941250 0.06916667 0.00000000 -0.0691666667 5.068484e-02 3.223812e-16 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164941 E001 0.0000000       8 94813311 94813438 128 +      
ENSG00000164941 E002 1.1866387 0.0108539510 8.078946e-02 1.607736e-01 8 94822851 94823181 331 + 0.382 0.000 -10.874
ENSG00000164941 E003 0.0000000       8 94823210 94823239 30 +      
ENSG00000164941 E004 1.0414780 0.0897043773 7.804261e-01 8.588903e-01 8 94823240 94823286 47 + 0.275 0.340 0.430
ENSG00000164941 E005 1.0414780 0.0897043773 7.804261e-01 8.588903e-01 8 94823287 94823289 3 + 0.275 0.340 0.430
ENSG00000164941 E006 2.2948374 0.0064609769 7.604243e-01 8.445488e-01 8 94823290 94823297 8 + 0.468 0.532 0.308
ENSG00000164941 E007 2.4400101 0.0058913814 8.703086e-01 9.205831e-01 8 94823298 94823298 1 + 0.494 0.532 0.182
ENSG00000164941 E008 3.3194653 0.0047292077 5.687938e-01 6.954127e-01 8 94823299 94823301 3 + 0.621 0.532 -0.402
ENSG00000164941 E009 7.5060421 0.0021679891 4.753356e-03 1.524252e-02 8 94823302 94823306 5 + 0.960 0.532 -1.756
ENSG00000164941 E010 37.5183531 0.0033554568 5.372388e-03 1.694189e-02 8 94823307 94823375 69 + 1.576 1.377 -0.684
ENSG00000164941 E011 70.1653741 0.0004281721 4.752304e-06 3.400603e-05 8 94823376 94823561 186 + 1.847 1.615 -0.784
ENSG00000164941 E012 92.9148049 0.0004884188 1.162804e-06 9.523159e-06 8 94824893 94825067 175 + 1.964 1.750 -0.720
ENSG00000164941 E013 106.5901039 0.0002848051 5.110380e-08 5.498644e-07 8 94827263 94827403 141 + 2.025 1.803 -0.748
ENSG00000164941 E014 94.2359081 0.0016084723 7.191014e-07 6.159866e-06 8 94827722 94827793 72 + 1.975 1.741 -0.790
ENSG00000164941 E015 64.3449552 0.0009200403 1.097311e-05 7.223401e-05 8 94828975 94828991 17 + 1.813 1.575 -0.805
ENSG00000164941 E016 65.7735566 0.0007200512 2.708641e-07 2.528425e-06 8 94828992 94829026 35 + 1.828 1.547 -0.953
ENSG00000164941 E017 126.9819390 0.0022793393 3.893793e-05 2.250702e-04 8 94831992 94832174 183 + 2.091 1.917 -0.583
ENSG00000164941 E018 106.7082477 0.0021319672 1.631731e-02 4.342640e-02 8 94836524 94836631 108 + 2.001 1.901 -0.336
ENSG00000164941 E019 53.5658103 0.0340632853 8.806302e-02 1.721789e-01 8 94838463 94838493 31 + 1.721 1.557 -0.559
ENSG00000164941 E020 105.5094015 0.0003614812 1.867104e-03 6.812344e-03 8 94838494 94838618 125 + 2.001 1.885 -0.392
ENSG00000164941 E021 118.7254553 0.0003202295 3.701356e-03 1.230065e-02 8 94841491 94841591 101 + 2.048 1.948 -0.337
ENSG00000164941 E022 142.3785417 0.0002811947 5.272171e-03 1.667274e-02 8 94842347 94842488 142 + 2.122 2.036 -0.289
ENSG00000164941 E023 104.8479482 0.0099910293 8.564171e-01 9.112211e-01 8 94849462 94849532 71 + 1.970 1.965 -0.019
ENSG00000164941 E024 190.9017807 0.0026330231 1.131199e-01 2.100871e-01 8 94849916 94850091 176 + 2.239 2.188 -0.172
ENSG00000164941 E025 161.7577797 0.0002559826 6.019676e-02 1.269427e-01 8 94851553 94851686 134 + 2.169 2.120 -0.162
ENSG00000164941 E026 0.2998086 0.0289068031 3.832028e-01   8 94853794 94853804 11 + 0.071 0.204 1.765
ENSG00000164941 E027 122.9891076 0.0002543129 7.460295e-01 8.338971e-01 8 94853805 94853915 111 + 2.037 2.038 0.003
ENSG00000164941 E028 143.8965182 0.0002985035 1.544915e-01 2.677444e-01 8 94856777 94856962 186 + 2.115 2.079 -0.122
ENSG00000164941 E029 65.3714756 0.0005201373 2.123448e-02 5.408180e-02 8 94856963 94856978 16 + 1.794 1.685 -0.367
ENSG00000164941 E030 130.8700842 0.0002530952 8.421824e-02 1.661656e-01 8 94859511 94859632 122 + 2.078 2.028 -0.167
ENSG00000164941 E031 4.6395097 0.0070383609 5.483669e-02 1.177180e-01 8 94859633 94860347 715 + 0.774 0.447 -1.454
ENSG00000164941 E032 0.7416694 0.0179499197 8.851139e-01 9.305595e-01 8 94864693 94864744 52 + 0.232 0.204 -0.234
ENSG00000164941 E033 145.9286454 0.0002465169 5.285849e-01 6.615071e-01 8 94865506 94865619 114 + 2.115 2.106 -0.029
ENSG00000164941 E034 127.4871623 0.0003855490 9.568984e-01 9.769656e-01 8 94865620 94865690 71 + 2.049 2.063 0.049
ENSG00000164941 E035 3.2181835 0.0049539017 2.405519e-01 3.748115e-01 8 94865691 94865700 10 + 0.518 0.716 0.875
ENSG00000164941 E036 85.3705492 0.0003331291 7.053119e-01 8.037199e-01 8 94866158 94866191 34 + 1.872 1.901 0.098
ENSG00000164941 E037 5.0448322 0.0263122433 4.697054e-01 6.089308e-01 8 94866192 94866311 120 + 0.688 0.810 0.492
ENSG00000164941 E038 5.2112232 0.0096335763 5.235694e-01 6.572259e-01 8 94866312 94866351 40 + 0.704 0.808 0.419
ENSG00000164941 E039 3.9817126 0.0043797228 7.061486e-01 8.043535e-01 8 94866352 94866353 2 + 0.656 0.603 -0.230
ENSG00000164941 E040 13.7088441 0.0644298609 9.387622e-01 9.655432e-01 8 94866737 94867030 294 + 1.108 1.172 0.230
ENSG00000164941 E041 7.7273052 0.0184448060 2.261964e-01 3.578444e-01 8 94867031 94867139 109 + 0.845 1.023 0.672
ENSG00000164941 E042 87.0468650 0.0003451883 3.859150e-02 8.843755e-02 8 94867140 94867172 33 + 1.865 1.965 0.336
ENSG00000164941 E043 99.8830580 0.0003233415 2.624948e-02 6.445168e-02 8 94867173 94867196 24 + 1.923 2.023 0.337
ENSG00000164941 E044 6.0572872 0.1082316282 2.365082e-02 5.909187e-02 8 94867197 94867275 79 + 0.639 1.059 1.640
ENSG00000164941 E045 141.5421385 0.0003723830 9.995270e-03 2.874975e-02 8 94867276 94867327 52 + 2.073 2.172 0.332
ENSG00000164941 E046 108.7837664 0.0003788051 7.419325e-02 1.502495e-01 8 94867328 94867337 10 + 1.964 2.045 0.272
ENSG00000164941 E047 0.1482932 0.0410137566 1.367452e-01   8 94867338 94867840 503 + 0.000 0.204 11.121
ENSG00000164941 E048 0.5922303 0.0179934769 9.596478e-01 9.786476e-01 8 94868692 94868813 122 + 0.184 0.204 0.182
ENSG00000164941 E049 186.9991275 0.0002639448 1.916381e-04 9.280723e-04 8 94871884 94872002 119 + 2.187 2.307 0.401
ENSG00000164941 E050 161.5942015 0.0008696917 6.670702e-07 5.754494e-06 8 94873374 94873477 104 + 2.106 2.281 0.585
ENSG00000164941 E051 7.1704512 0.0023714985 7.202132e-01 8.148627e-01 8 94873478 94873752 275 + 0.856 0.914 0.223
ENSG00000164941 E052 97.2972391 0.0003683830 5.432053e-06 3.835580e-05 8 94874552 94874602 51 + 1.882 2.072 0.637
ENSG00000164941 E053 2.9592762 0.0139157021 8.287783e-01 8.924345e-01 8 94875951 94876073 123 + 0.562 0.532 -0.138
ENSG00000164941 E054 134.0187371 0.0022020902 1.151633e-05 7.544818e-05 8 94876074 94876147 74 + 2.021 2.208 0.626
ENSG00000164941 E055 10.4338685 0.0577685584 6.318273e-02 1.320089e-01 8 94876148 94876220 73 + 0.897 1.198 1.100
ENSG00000164941 E056 142.9374946 0.0108649130 2.922421e-04 1.348213e-03 8 94876221 94876285 65 + 2.030 2.263 0.780
ENSG00000164941 E057 115.2844785 0.0046879499 4.318862e-07 3.868902e-06 8 94876446 94876489 44 + 1.930 2.185 0.855
ENSG00000164941 E058 3.4802273 0.0995053090 2.994147e-01 4.409104e-01 8 94876490 94876646 157 + 0.540 0.795 1.086
ENSG00000164941 E059 119.6247254 0.0098894261 4.099991e-05 2.357659e-04 8 94880118 94881746 1629 + 1.943 2.201 0.865