ENSG00000164930

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358755 ENSG00000164930 HEK293_OSMI2_2hA HEK293_TMG_2hB FZD6 protein_coding protein_coding 7.83295 1.675016 12.77868 0.2966673 0.4379344 2.924033 5.06443537 1.0302709 8.386247 0.05080020 0.5205474 3.012785 0.65431667 0.64570000 0.65683333 0.01113333 9.941964e-01 2.779922e-09 FALSE TRUE
ENST00000522484 ENSG00000164930 HEK293_OSMI2_2hA HEK293_TMG_2hB FZD6 protein_coding nonsense_mediated_decay 7.83295 1.675016 12.77868 0.2966673 0.4379344 2.924033 0.75862385 0.0000000 1.151438 0.00000000 0.2370868 6.859769 0.07566250 0.00000000 0.08936667 0.08936667 4.194432e-04 2.779922e-09 TRUE TRUE
ENST00000523739 ENSG00000164930 HEK293_OSMI2_2hA HEK293_TMG_2hB FZD6 protein_coding protein_coding 7.83295 1.675016 12.77868 0.2966673 0.4379344 2.924033 0.08770161 0.1807951 0.000000 0.18079508 0.0000000 -4.253952 0.05992917 0.12250000 0.00000000 -0.12250000 4.878270e-01 2.779922e-09 FALSE TRUE
ENST00000523933 ENSG00000164930 HEK293_OSMI2_2hA HEK293_TMG_2hB FZD6 protein_coding nonsense_mediated_decay 7.83295 1.675016 12.77868 0.2966673 0.4379344 2.924033 1.75855032 0.0000000 3.204886 0.00000000 0.3880049 8.328624 0.12510833 0.00000000 0.25093333 0.25093333 2.779922e-09 2.779922e-09 FALSE TRUE
MSTRG.31955.2 ENSG00000164930 HEK293_OSMI2_2hA HEK293_TMG_2hB FZD6 protein_coding   7.83295 1.675016 12.77868 0.2966673 0.4379344 2.924033 0.06254078 0.1047821 0.000000 0.07030176 0.0000000 -3.520826 0.04397917 0.07276667 0.00000000 -0.07276667 1.755904e-02 2.779922e-09 FALSE TRUE
MSTRG.31955.8 ENSG00000164930 HEK293_OSMI2_2hA HEK293_TMG_2hB FZD6 protein_coding   7.83295 1.675016 12.77868 0.2966673 0.4379344 2.924033 0.04748360 0.3591680 0.000000 0.35916800 0.0000000 -5.206206 0.02237083 0.15903333 0.00000000 -0.15903333 4.155618e-01 2.779922e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164930 E001 0.3030308 0.3912346127 1.000000e+00   8 103298433 103298570 138 + 0.091 0.001 -7.084
ENSG00000164930 E002 1.7014481 0.0080970104 5.195467e-02 1.126497e-01 8 103298831 103298858 28 + 0.259 0.666 2.159
ENSG00000164930 E003 2.4701859 0.0060706574 5.966436e-02 1.260481e-01 8 103298859 103298864 6 + 0.358 0.744 1.829
ENSG00000164930 E004 3.2065448 0.0049174545 1.809119e-01 3.023635e-01 8 103298865 103298875 11 + 0.457 0.744 1.289
ENSG00000164930 E005 8.7214457 0.0163418829 5.786909e-01 7.037298e-01 8 103298876 103298897 22 + 0.848 0.810 -0.147
ENSG00000164930 E006 29.2583771 0.0007498169 6.149447e-04 2.588034e-03 8 103298898 103298995 98 + 1.353 1.042 -1.105
ENSG00000164930 E007 0.1515154 0.0441456491 8.169654e-01   8 103299954 103299955 2 + 0.048 0.000 -7.484
ENSG00000164930 E008 43.9920744 0.0005816120 1.698711e-06 1.342185e-05 8 103299956 103300084 129 + 1.526 1.138 -1.355
ENSG00000164930 E009 37.9266330 0.0005300352 4.958247e-04 2.143990e-03 8 103300085 103300199 115 + 1.456 1.192 -0.922
ENSG00000164930 E010 37.1883105 0.0007416728 3.657015e-03 1.217422e-02 8 103300200 103300284 85 + 1.444 1.240 -0.709
ENSG00000164930 E011 0.4783925 0.0216877424 3.242720e-01 4.676310e-01 8 103307751 103307880 130 + 0.091 0.281 1.967
ENSG00000164930 E012 53.9885256 0.0022902593 1.303075e-02 3.598386e-02 8 103318590 103318786 197 + 1.592 1.466 -0.432
ENSG00000164930 E013 103.3836641 0.0003447674 3.034669e-03 1.036825e-02 8 103324481 103325034 554 + 1.865 1.779 -0.289
ENSG00000164930 E014 21.6049843 0.0009121675 7.566514e-03 2.268625e-02 8 103325035 103325053 19 + 1.226 0.963 -0.951
ENSG00000164930 E015 104.5453842 0.0002780313 1.978134e-02 5.102519e-02 8 103325054 103325498 445 + 1.866 1.817 -0.167
ENSG00000164930 E016 66.4372712 0.0004477820 2.320042e-01 3.648296e-01 8 103328268 103328416 149 + 1.667 1.659 -0.029
ENSG00000164930 E017 117.0083245 0.0004723848 4.819073e-02 1.059707e-01 8 103329655 103330065 411 + 1.910 1.884 -0.088
ENSG00000164930 E018 183.0808057 0.0055387743 1.970856e-23 1.832954e-21 8 103331341 103332866 1526 + 2.013 2.446 1.446