ENSG00000164877

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297508 ENSG00000164877 HEK293_OSMI2_2hA HEK293_TMG_2hB MICALL2 protein_coding protein_coding 4.814284 5.120483 3.472892 0.5901788 0.259386 -0.5588086 0.8606871 1.10206849 0.85484368 0.30774464 0.07954921 -0.36273435 0.17766250 0.20746667 0.24766667 0.04020000 7.707414e-01 1.030121e-11 FALSE TRUE
ENST00000413446 ENSG00000164877 HEK293_OSMI2_2hA HEK293_TMG_2hB MICALL2 protein_coding nonsense_mediated_decay 4.814284 5.120483 3.472892 0.5901788 0.259386 -0.5588086 0.2951078 0.14436376 0.04690312 0.10842500 0.02352972 -1.43975435 0.06270833 0.03163333 0.01423333 -0.01740000 9.769534e-01 1.030121e-11 TRUE TRUE
ENST00000467783 ENSG00000164877 HEK293_OSMI2_2hA HEK293_TMG_2hB MICALL2 protein_coding retained_intron 4.814284 5.120483 3.472892 0.5901788 0.259386 -0.5588086 0.4577997 0.05830250 0.42861017 0.05830250 0.32370629 2.68292903 0.08977917 0.01220000 0.11896667 0.10676667 4.830284e-01 1.030121e-11   FALSE
ENST00000472100 ENSG00000164877 HEK293_OSMI2_2hA HEK293_TMG_2hB MICALL2 protein_coding retained_intron 4.814284 5.120483 3.472892 0.5901788 0.259386 -0.5588086 0.2976200 0.24719310 0.24981499 0.05420930 0.05288508 0.01463268 0.06435833 0.04743333 0.07146667 0.02403333 6.052888e-01 1.030121e-11 TRUE TRUE
ENST00000487156 ENSG00000164877 HEK293_OSMI2_2hA HEK293_TMG_2hB MICALL2 protein_coding retained_intron 4.814284 5.120483 3.472892 0.5901788 0.259386 -0.5588086 0.2548126 0.04976018 0.31862115 0.01725087 0.06042661 2.45916889 0.05597917 0.00960000 0.09520000 0.08560000 7.081599e-04 1.030121e-11 FALSE FALSE
ENST00000496184 ENSG00000164877 HEK293_OSMI2_2hA HEK293_TMG_2hB MICALL2 protein_coding retained_intron 4.814284 5.120483 3.472892 0.5901788 0.259386 -0.5588086 0.5332530 0.34290611 0.47554555 0.08343718 0.02188084 0.46032222 0.11028750 0.06506667 0.13800000 0.07293333 4.354556e-02 1.030121e-11 TRUE FALSE
MSTRG.29364.19 ENSG00000164877 HEK293_OSMI2_2hA HEK293_TMG_2hB MICALL2 protein_coding   4.814284 5.120483 3.472892 0.5901788 0.259386 -0.5588086 1.4315232 1.91710514 0.92547569 0.21400330 0.33243980 -1.04266321 0.29611667 0.37486667 0.26390000 -0.11096667 5.181496e-01 1.030121e-11   FALSE
MSTRG.29364.6 ENSG00000164877 HEK293_OSMI2_2hA HEK293_TMG_2hB MICALL2 protein_coding   4.814284 5.120483 3.472892 0.5901788 0.259386 -0.5588086 0.1147399 0.81927198 0.00000000 0.05487902 0.00000000 -6.37377345 0.02252083 0.16273333 0.00000000 -0.16273333 1.030121e-11 1.030121e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164877 E001 0.0000000       7 1428465 1428478 14 -      
ENSG00000164877 E002 1.2660317 0.0139364524 2.715678e-02 6.631567e-02 7 1428479 1428618 140 - 0.560 0.171 -2.441
ENSG00000164877 E003 3.1869609 0.0053105114 5.562567e-02 1.190524e-01 7 1428619 1428791 173 - 0.765 0.468 -1.314
ENSG00000164877 E004 2.2185754 0.1334302086 2.183537e-01 3.484254e-01 7 1434210 1434358 149 - 0.654 0.388 -1.285
ENSG00000164877 E005 0.9996594 0.8681389136 7.395367e-01 8.292033e-01 7 1434359 1434359 1 - 0.367 0.239 -0.852
ENSG00000164877 E006 1.7767146 0.2830081367 7.173410e-01 8.127585e-01 7 1434360 1434365 6 - 0.505 0.386 -0.621
ENSG00000164877 E007 28.9434241 0.0069273153 6.898173e-02 1.416873e-01 7 1434366 1434672 307 - 1.343 1.479 0.470
ENSG00000164877 E008 9.4261760 0.0134550744 2.926349e-02 7.051310e-02 7 1434673 1434899 227 - 1.137 0.879 -0.949
ENSG00000164877 E009 7.5170087 0.0023946315 8.840943e-01 9.298948e-01 7 1434900 1435100 201 - 0.879 0.891 0.046
ENSG00000164877 E010 18.1892564 0.0011141620 2.752642e-03 9.529617e-03 7 1435101 1435147 47 - 1.044 1.309 0.944
ENSG00000164877 E011 11.7387215 0.0015483628 1.609099e-01 2.763074e-01 7 1436742 1436742 1 - 0.969 1.109 0.511
ENSG00000164877 E012 19.8834429 0.0010362547 1.886413e-02 4.903478e-02 7 1436743 1436856 114 - 1.137 1.329 0.680
ENSG00000164877 E013 13.9073805 0.0059268430 4.149050e-03 1.356081e-02 7 1436857 1437433 577 - 1.297 1.021 -0.989
ENSG00000164877 E014 4.3942040 0.0311357625 5.354270e-01 6.672567e-01 7 1437434 1437534 101 - 0.609 0.714 0.444
ENSG00000164877 E015 7.8585276 0.0046536096 1.504829e-03 5.651746e-03 7 1437535 1437535 1 - 0.560 0.999 1.772
ENSG00000164877 E016 15.3150566 0.0054220673 2.933578e-02 7.065402e-02 7 1437536 1437608 73 - 1.008 1.225 0.780
ENSG00000164877 E017 0.8909948 0.0134024109 1.822190e-02 4.761692e-02 7 1437609 1437611 3 - 0.504 0.094 -3.179
ENSG00000164877 E018 13.0182643 0.0019025415 2.629177e-01 4.007448e-01 7 1437890 1437980 91 - 1.027 1.133 0.387
ENSG00000164877 E019 2.3097870 0.1703128201 1.580634e-02 4.230246e-02 7 1437981 1438096 116 - 0.766 0.243 -2.690
ENSG00000164877 E020 18.6744477 0.0011019764 1.633793e-01 2.795671e-01 7 1438097 1438220 124 - 1.176 1.288 0.393
ENSG00000164877 E021 2.4616742 0.0063667566 2.418732e-01 3.763936e-01 7 1438221 1438288 68 - 0.364 0.564 1.020
ENSG00000164877 E022 12.4453570 0.0016298185 8.823717e-01 9.286815e-01 7 1438289 1438353 65 - 1.093 1.101 0.029
ENSG00000164877 E023 7.1984555 0.0024747486 5.945107e-02 1.256970e-01 7 1438354 1438839 486 - 1.027 0.801 -0.856
ENSG00000164877 E024 14.4184138 0.0133920351 5.038763e-01 6.398151e-01 7 1438840 1438924 85 - 1.213 1.138 -0.265
ENSG00000164877 E025 14.5669054 0.0014221368 9.507107e-01 9.731535e-01 7 1438925 1438991 67 - 1.164 1.163 -0.003
ENSG00000164877 E026 8.0295538 0.0021941769 3.743856e-01 5.188041e-01 7 1438992 1438995 4 - 0.853 0.953 0.381
ENSG00000164877 E027 11.4095744 0.0116685622 3.934675e-02 8.981521e-02 7 1438996 1439871 876 - 1.201 0.977 -0.810
ENSG00000164877 E028 20.6863651 0.0012109967 2.628162e-01 4.006320e-01 7 1439925 1440085 161 - 1.246 1.329 0.288
ENSG00000164877 E029 5.4210297 0.0033619651 1.909730e-06 1.491990e-05 7 1440086 1440590 505 - 1.093 0.468 -2.555
ENSG00000164877 E030 20.1883677 0.0010745511 4.648185e-01 6.045024e-01 7 1440591 1440684 94 - 1.257 1.309 0.181
ENSG00000164877 E031 11.7546085 0.0059382465 7.501047e-10 1.139302e-08 7 1440685 1442191 1507 - 1.392 0.767 -2.285
ENSG00000164877 E032 33.4096953 0.0009925335 3.277611e-01 4.712361e-01 7 1442192 1442484 293 - 1.463 1.518 0.189
ENSG00000164877 E033 12.9312490 0.0233338027 6.111562e-01 7.303411e-01 7 1444652 1444729 78 - 1.077 1.132 0.197
ENSG00000164877 E034 14.6401592 0.0012823038 7.024244e-01 8.012536e-01 7 1444730 1444874 145 - 1.189 1.148 -0.145
ENSG00000164877 E035 12.5775320 0.0016580998 7.945645e-02 1.586699e-01 7 1444875 1445070 196 - 1.201 1.029 -0.620
ENSG00000164877 E036 6.1560430 0.0029978007 8.361021e-01 8.975099e-01 7 1445071 1445124 54 - 0.796 0.818 0.085
ENSG00000164877 E037 15.5581933 0.0011930158 7.812069e-01 8.594401e-01 7 1445125 1445428 304 - 1.201 1.170 -0.109
ENSG00000164877 E038 0.1515154 0.0418306498 2.791517e-01   7 1446657 1446712 56 - 0.158 0.000 -10.354
ENSG00000164877 E039 11.2898532 0.0039159427 9.943445e-01 1.000000e+00 7 1446713 1446828 116 - 1.044 1.040 -0.017
ENSG00000164877 E040 16.1515815 0.0011271224 6.944696e-01 7.952922e-01 7 1447575 1447765 191 - 1.224 1.184 -0.142
ENSG00000164877 E041 1.1739638 0.0124191068 2.613491e-01 3.989863e-01 7 1447766 1448033 268 - 0.439 0.237 -1.269
ENSG00000164877 E042 16.0124847 0.0077688970 9.788529e-01 9.908412e-01 7 1448620 1448761 142 - 1.189 1.187 -0.007
ENSG00000164877 E043 15.4485677 0.0013317803 4.146310e-02 9.374028e-02 7 1449570 1449829 260 - 1.044 1.230 0.666
ENSG00000164877 E044 17.2126590 0.0011499645 2.333364e-01 3.663742e-01 7 1450240 1450288 49 - 1.150 1.248 0.347
ENSG00000164877 E045 1.8529609 0.0134443194 9.741075e-01 9.878368e-01 7 1450289 1450536 248 - 0.440 0.430 -0.049
ENSG00000164877 E046 22.6250751 0.0009751692 8.358887e-01 8.974028e-01 7 1459184 1459470 287 - 1.325 1.334 0.031