ENSG00000164823

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000451899 ENSG00000164823 HEK293_OSMI2_2hA HEK293_TMG_2hB OSGIN2 protein_coding protein_coding 6.588396 3.266464 10.4607 0.1735195 0.6379908 1.676146 1.713751 0.1827006 4.506786 0.1181536 1.0326377 4.5508632 0.2007333 0.0542000 0.4347333 0.3805333 0.02033345 0.02033345 FALSE TRUE
ENST00000520659 ENSG00000164823 HEK293_OSMI2_2hA HEK293_TMG_2hB OSGIN2 protein_coding protein_coding 6.588396 3.266464 10.4607 0.1735195 0.6379908 1.676146 2.489897 1.0748769 3.802595 0.1714020 0.6588059 1.8132420 0.3701792 0.3313667 0.3587667 0.0274000 0.88478957 0.02033345 FALSE TRUE
MSTRG.31777.7 ENSG00000164823 HEK293_OSMI2_2hA HEK293_TMG_2hB OSGIN2 protein_coding   6.588396 3.266464 10.4607 0.1735195 0.6379908 1.676146 2.145114 2.0088868 1.634328 0.1462185 1.0778809 -0.2960616 0.3966542 0.6144667 0.1574333 -0.4570333 0.19831238 0.02033345 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164823 E001 0.1472490 0.0437128111 1.0000000000   8 89901786 89901848 63 + 0.074 0.000 -8.688
ENSG00000164823 E002 0.1472490 0.0437128111 1.0000000000   8 89901849 89901858 10 + 0.074 0.000 -10.176
ENSG00000164823 E003 0.4396707 0.0256398777 0.4163615940 0.559729709 8 89901859 89901911 53 + 0.192 0.000 -11.779
ENSG00000164823 E004 0.4396707 0.0256398777 0.4163615940 0.559729709 8 89901912 89902028 117 + 0.192 0.000 -11.779
ENSG00000164823 E005 0.7447779 0.0849170634 0.1957512240 0.320902729 8 89902029 89902125 97 + 0.285 0.000 -12.298
ENSG00000164823 E006 9.0671130 0.0065785155 0.0001266493 0.000644099 8 89902570 89902760 191 + 1.062 0.517 -2.204
ENSG00000164823 E007 12.1025611 0.0015800858 0.0010574312 0.004158150 8 89902761 89902837 77 + 1.150 0.789 -1.350
ENSG00000164823 E008 0.2214452 0.0468658077 0.1621919332   8 89904550 89904606 57 + 0.000 0.197 11.646
ENSG00000164823 E009 39.0202250 0.0006254734 0.0003894635 0.001733983 8 89909567 89909721 155 + 1.604 1.409 -0.672
ENSG00000164823 E010 31.6117384 0.0008925438 0.0802200008 0.159890567 8 89914077 89914118 42 + 1.494 1.408 -0.293
ENSG00000164823 E011 55.5148816 0.0231414707 0.3734009239 0.517852483 8 89914119 89914213 95 + 1.719 1.665 -0.182
ENSG00000164823 E012 77.7293999 0.0004878591 0.9505741338 0.973050440 8 89914555 89914746 192 + 1.840 1.881 0.135
ENSG00000164823 E013 48.8849140 0.0005384805 0.6158380697 0.734005302 8 89921080 89921171 92 + 1.641 1.706 0.220
ENSG00000164823 E014 4.9163352 0.0036996539 0.0805744077 0.160456567 8 89921172 89921319 148 + 0.655 0.926 1.080
ENSG00000164823 E015 376.2945398 0.0073792834 0.0124942898 0.034720065 8 89924503 89927888 3386 + 2.505 2.595 0.302