ENSG00000164818

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297440 ENSG00000164818 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF5 protein_coding protein_coding 63.60105 95.37907 41.66248 1.247071 0.5835964 -1.194729 8.758378 6.709498 13.6040083 1.9460892 0.5784839 1.018666 0.1554250 0.0700000 0.32696667 0.256966667 3.374059e-05 3.374059e-05 FALSE TRUE
ENST00000438961 ENSG00000164818 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF5 protein_coding processed_transcript 63.60105 95.37907 41.66248 1.247071 0.5835964 -1.194729 6.957957 10.993052 0.9229871 0.9884432 0.9229871 -3.559903 0.1087792 0.1150667 0.02186667 -0.093200000 8.526732e-02 3.374059e-05 FALSE TRUE
ENST00000440747 ENSG00000164818 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF5 protein_coding protein_coding 63.60105 95.37907 41.66248 1.247071 0.5835964 -1.194729 15.931796 20.313135 9.7008209 0.9712623 1.6146649 -1.065458 0.2546375 0.2131000 0.23183333 0.018733333 9.130612e-01 3.374059e-05 FALSE TRUE
ENST00000461576 ENSG00000164818 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF5 protein_coding retained_intron 63.60105 95.37907 41.66248 1.247071 0.5835964 -1.194729 11.783692 28.414129 3.1760266 4.8413025 1.2551526 -3.157286 0.1560917 0.2988667 0.07573333 -0.223133333 4.940733e-03 3.374059e-05   FALSE
MSTRG.29355.6 ENSG00000164818 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF5 protein_coding   63.60105 95.37907 41.66248 1.247071 0.5835964 -1.194729 18.637410 27.483377 12.2465233 2.3431232 1.8558643 -1.165534 0.2977458 0.2876333 0.29526667 0.007633333 1.000000e+00 3.374059e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164818 E001 2.687391 0.0672314153 3.573679e-02 8.307537e-02 7 726511 726698 188 + 0.757 0.395 -1.669
ENSG00000164818 E002 110.147370 0.0368293167 5.912698e-09 7.619501e-08 7 726699 727218 520 + 2.305 1.755 -1.845
ENSG00000164818 E003 42.385212 0.0385344235 1.142420e-06 9.369993e-06 7 727219 727251 33 + 1.878 1.370 -1.729
ENSG00000164818 E004 38.400361 0.0426330282 3.179183e-05 1.880148e-04 7 727252 727254 3 + 1.811 1.363 -1.533
ENSG00000164818 E005 83.119414 0.0161313045 6.294579e-06 4.381574e-05 7 727255 727315 61 + 2.075 1.769 -1.028
ENSG00000164818 E006 136.306124 0.0091149803 2.641860e-03 9.196341e-03 7 729663 729724 62 + 2.199 2.052 -0.491
ENSG00000164818 E007 245.420419 0.0044572926 1.145900e-02 3.225523e-02 7 729725 729847 123 + 2.413 2.331 -0.273
ENSG00000164818 E008 217.884875 0.0021431686 1.062914e-01 2.000694e-01 7 740819 740943 125 + 2.335 2.296 -0.130
ENSG00000164818 E009 164.028106 0.0040449990 1.514742e-01 2.636809e-01 7 741347 741465 119 + 2.218 2.174 -0.148
ENSG00000164818 E010 0.000000       7 750868 750953 86 +      
ENSG00000164818 E011 351.380847 0.0015486784 1.767665e-02 4.643940e-02 7 754589 754821 233 + 2.547 2.499 -0.160
ENSG00000164818 E012 540.653032 0.0021476853 2.038430e-01 3.310093e-01 7 756782 756994 213 + 2.715 2.697 -0.058
ENSG00000164818 E013 454.107403 0.0001336452 7.844469e-02 1.569913e-01 7 761753 761896 144 + 2.638 2.620 -0.060
ENSG00000164818 E014 369.095089 0.0001344083 9.697420e-01 9.850444e-01 7 763806 763906 101 + 2.527 2.541 0.046
ENSG00000164818 E015 320.687817 0.0001649819 7.985617e-01 8.714630e-01 7 763907 763974 68 + 2.470 2.478 0.025
ENSG00000164818 E016 6.277356 0.0321915877 7.523025e-01 8.385619e-01 7 768475 769205 731 + 0.845 0.813 -0.126
ENSG00000164818 E017 469.398686 0.0002015320 1.385034e-01 2.460180e-01 7 770471 770618 148 + 2.614 2.654 0.133
ENSG00000164818 E018 4.238176 0.0649947534 8.245121e-01 8.894534e-01 7 770619 772975 2357 + 0.723 0.707 -0.064
ENSG00000164818 E019 479.042567 0.0006750148 6.543284e-02 1.357681e-01 7 774048 774198 151 + 2.614 2.666 0.172
ENSG00000164818 E020 565.841743 0.0002495898 9.263620e-01 9.576286e-01 7 775006 775162 157 + 2.710 2.725 0.050
ENSG00000164818 E021 6.429477 0.0048606283 4.438345e-01 5.854147e-01 7 778182 778685 504 + 0.895 0.809 -0.333
ENSG00000164818 E022 1.546723 0.0140649929 3.705141e-01 5.149496e-01 7 779904 779952 49 + 0.497 0.349 -0.797
ENSG00000164818 E023 660.251852 0.0001191377 3.682979e-02 8.514501e-02 7 779953 780144 192 + 2.758 2.802 0.146
ENSG00000164818 E024 1819.269045 0.0070304447 9.189723e-05 4.839107e-04 7 785517 786475 959 + 3.128 3.273 0.481