ENSG00000164754

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297338 ENSG00000164754 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD21 protein_coding protein_coding 59.53676 17.7001 96.5936 1.19051 3.460324 2.447504 36.633713 5.793301 59.311109 0.9130027 2.289923 3.353600 0.52888750 0.33750000 0.61410000 0.2766000 1.760641e-02 4.627984e-05 FALSE TRUE
ENST00000517485 ENSG00000164754 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD21 protein_coding protein_coding 59.53676 17.7001 96.5936 1.19051 3.460324 2.447504 7.579188 1.540407 20.735557 0.8191765 2.464911 3.742084 0.09982083 0.09096667 0.21420000 0.1232333 5.928588e-01 4.627984e-05 FALSE TRUE
ENST00000519837 ENSG00000164754 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD21 protein_coding protein_coding 59.53676 17.7001 96.5936 1.19051 3.460324 2.447504 10.822475 9.944003 6.623944 2.7021488 1.720551 -0.585410 0.31051667 0.54650000 0.06813333 -0.4783667 4.627984e-05 4.627984e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164754 E001 11.6562939 0.0014853883 5.434034e-08 5.810585e-07 8 116845934 116845939 6 - 0.813 1.409 2.161
ENSG00000164754 E002 15.4472090 0.0012850496 1.918474e-16 7.959902e-15 8 116845940 116845947 8 - 0.849 1.613 2.723
ENSG00000164754 E003 244.0841187 0.0156134056 8.190143e-07 6.928942e-06 8 116845948 116846065 118 - 2.176 2.564 1.297
ENSG00000164754 E004 342.6442509 0.0110225701 1.487049e-10 2.548784e-09 8 116846066 116846142 77 - 2.315 2.723 1.359
ENSG00000164754 E005 1484.1247455 0.0037775979 1.336861e-17 6.460823e-16 8 116846143 116846904 762 - 2.991 3.271 0.932
ENSG00000164754 E006 956.8085868 0.0001598383 3.525015e-09 4.720794e-08 8 116846905 116847333 429 - 2.839 2.974 0.447
ENSG00000164754 E007 633.9533676 0.0001189510 2.516299e-01 3.878964e-01 8 116847334 116847691 358 - 2.674 2.744 0.231
ENSG00000164754 E008 9.7237652 0.0017090237 1.117632e-02 3.158952e-02 8 116847692 116848334 643 - 0.973 0.610 -1.448
ENSG00000164754 E009 6.3537344 0.0045755816 1.586358e-02 4.243092e-02 8 116848335 116848890 556 - 0.822 0.404 -1.875
ENSG00000164754 E010 0.7427016 0.0153787590 4.059336e-01 5.495891e-01 8 116848891 116848904 14 - 0.227 0.000 -10.744
ENSG00000164754 E011 1.0351233 0.0120727605 2.362798e-01 3.698586e-01 8 116848905 116848945 41 - 0.293 0.000 -11.270
ENSG00000164754 E012 361.0302881 0.0016274235 5.803467e-01 7.051117e-01 8 116848946 116849029 84 - 2.430 2.493 0.210
ENSG00000164754 E013 4.4976599 0.0034697084 1.038609e-01 1.963882e-01 8 116849030 116849054 25 - 0.686 0.405 -1.324
ENSG00000164754 E014 16.6851571 0.0010871657 2.960205e-03 1.014494e-02 8 116849055 116850124 1070 - 1.185 0.855 -1.218
ENSG00000164754 E015 11.3594361 0.0015121719 6.180801e-02 1.296672e-01 8 116850125 116850617 493 - 1.021 0.805 -0.819
ENSG00000164754 E016 480.9654436 0.0003455162 9.250273e-02 1.790320e-01 8 116850618 116850767 150 - 2.565 2.576 0.036
ENSG00000164754 E017 5.6544870 0.1343588045 1.199427e-01 2.198965e-01 8 116850768 116851947 1180 - 0.766 0.409 -1.626
ENSG00000164754 E018 446.5995074 0.0001279257 1.083772e-04 5.606392e-04 8 116851948 116852096 149 - 2.541 2.502 -0.130
ENSG00000164754 E019 10.7682511 0.0018005047 1.478774e-02 4.001446e-02 8 116852097 116852548 452 - 1.010 0.685 -1.262
ENSG00000164754 E020 415.0301335 0.0003961868 9.123647e-07 7.638872e-06 8 116852549 116852708 160 - 2.515 2.439 -0.253
ENSG00000164754 E021 3.7278884 0.0041948713 5.734759e-01 6.994075e-01 8 116852709 116854244 1536 - 0.590 0.520 -0.324
ENSG00000164754 E022 572.2163733 0.0033762634 5.941584e-05 3.285509e-04 8 116854245 116854468 224 - 2.657 2.565 -0.306
ENSG00000164754 E023 443.9379802 0.0047955164 2.563640e-05 1.550040e-04 8 116856166 116856288 123 - 2.553 2.425 -0.425
ENSG00000164754 E024 404.3854694 0.0040653812 4.511922e-07 4.026047e-06 8 116856646 116856771 126 - 2.516 2.358 -0.525
ENSG00000164754 E025 1.9490339 0.0074213102 3.475996e-01 4.918050e-01 8 116856772 116857266 495 - 0.423 0.248 -1.102
ENSG00000164754 E026 557.1346601 0.0001304821 6.414731e-24 6.316276e-22 8 116857267 116857473 207 - 2.656 2.485 -0.569
ENSG00000164754 E027 405.8189920 0.0099776275 7.585293e-06 5.178978e-05 8 116858352 116858458 107 - 2.523 2.318 -0.684
ENSG00000164754 E028 1.0351233 0.0120727605 2.362798e-01 3.698586e-01 8 116858459 116859046 588 - 0.293 0.000 -11.270
ENSG00000164754 E029 312.0088204 0.0047641444 1.787515e-07 1.729958e-06 8 116861841 116861921 81 - 2.407 2.216 -0.639
ENSG00000164754 E030 156.6284122 0.0120469445 2.607972e-04 1.219902e-03 8 116861922 116861940 19 - 2.111 1.901 -0.704
ENSG00000164754 E031 342.1810639 0.0056907827 5.668736e-08 6.036678e-07 8 116863130 116863259 130 - 2.449 2.238 -0.705
ENSG00000164754 E032 11.5202144 0.0014941936 7.206524e-05 3.902287e-04 8 116863260 116866231 2972 - 1.054 0.405 -2.746
ENSG00000164754 E033 304.7386235 0.0028377799 2.608500e-14 8.070758e-13 8 116866586 116866761 176 - 2.405 2.139 -0.889
ENSG00000164754 E034 0.6192988 0.0215994055 6.560556e-01 7.658025e-01 8 116866762 116866991 230 - 0.150 0.248 0.899
ENSG00000164754 E035 0.4439371 0.0215788744 8.329760e-01 8.953700e-01 8 116874102 116874118 17 - 0.150 0.000 -9.929
ENSG00000164754 E036 1.0330470 0.0117949917 2.366334e-01 3.702775e-01 8 116874119 116874205 87 - 0.293 0.000 -11.274
ENSG00000164754 E037 1.5554467 0.0113644740 5.571804e-01 6.856478e-01 8 116874206 116874249 44 - 0.350 0.248 -0.686
ENSG00000164754 E038 1.5595994 0.0088602845 5.544937e-01 6.834648e-01 8 116874250 116874309 60 - 0.350 0.248 -0.686
ENSG00000164754 E039 7.5402580 0.0740948345 7.679631e-02 1.543654e-01 8 116874310 116874362 53 - 0.873 0.522 -1.477
ENSG00000164754 E040 20.6810013 0.0593377590 1.816601e-02 4.748792e-02 8 116874363 116874528 166 - 1.269 0.906 -1.318
ENSG00000164754 E041 66.3435648 0.0005408648 1.293520e-05 8.371597e-05 8 116874611 116874727 117 - 1.747 1.513 -0.796
ENSG00000164754 E042 7.0690550 0.0830242085 3.586545e-02 8.332237e-02 8 116874728 116874800 73 - 0.858 0.405 -2.012