ENSG00000164742

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297323 ENSG00000164742 HEK293_OSMI2_2hA HEK293_TMG_2hB ADCY1 protein_coding protein_coding 7.219871 9.320139 6.391481 0.634863 0.163622 -0.5434929 0.9247362 0.7650093 1.256522 0.1692599 0.13718099 0.7085863 0.1312167 0.08206667 0.1976667 0.11560000 0.020282789 0.002996028 FALSE TRUE
ENST00000621543 ENSG00000164742 HEK293_OSMI2_2hA HEK293_TMG_2hB ADCY1 protein_coding protein_coding 7.219871 9.320139 6.391481 0.634863 0.163622 -0.5434929 2.2264970 3.9492789 1.697183 0.4636927 0.03689093 -1.2136199 0.2925833 0.42213333 0.2656667 -0.15646667 0.002996028 0.002996028 FALSE TRUE
MSTRG.29829.1 ENSG00000164742 HEK293_OSMI2_2hA HEK293_TMG_2hB ADCY1 protein_coding   7.219871 9.320139 6.391481 0.634863 0.163622 -0.5434929 3.8526750 4.2432573 3.108518 0.2559278 0.19509524 -0.4477077 0.5447125 0.45596667 0.4858000 0.02983333 0.743485986 0.002996028 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164742 E001 0.0000000       7 45574063 45574139 77 +      
ENSG00000164742 E002 0.0000000       7 45574140 45574188 49 +      
ENSG00000164742 E003 10.8471743 0.0018130942 7.983877e-03 2.373737e-02 7 45574368 45574884 517 + 1.192 0.938 -0.927
ENSG00000164742 E004 7.1223945 0.0023574482 7.289811e-01 8.213051e-01 7 45574885 45574888 4 + 0.908 0.877 -0.121
ENSG00000164742 E005 48.7663270 0.0043713733 6.928726e-01 7.939758e-01 7 45574889 45575182 294 + 1.657 1.694 0.125
ENSG00000164742 E006 67.8967112 0.0047736218 2.776964e-01 4.173111e-01 7 45592759 45592908 150 + 1.778 1.851 0.247
ENSG00000164742 E007 70.7350415 0.0004094397 1.062713e-01 2.000369e-01 7 45610379 45610497 119 + 1.786 1.867 0.273
ENSG00000164742 E008 61.3174308 0.0004237476 2.362525e-01 3.698311e-01 7 45622632 45622743 112 + 1.739 1.804 0.221
ENSG00000164742 E009 52.8826674 0.0005683969 9.073674e-02 1.762967e-01 7 45648670 45648708 39 + 1.657 1.753 0.323
ENSG00000164742 E010 59.3503929 0.0004497332 3.067282e-01 4.489172e-01 7 45648709 45648797 89 + 1.730 1.788 0.198
ENSG00000164742 E011 63.6061532 0.0004313801 3.458877e-02 8.087603e-02 7 45657727 45657885 159 + 1.727 1.834 0.363
ENSG00000164742 E012 78.5139521 0.0003505984 3.290363e-01 4.725244e-01 7 45660042 45660183 142 + 1.855 1.905 0.170
ENSG00000164742 E013 81.9548305 0.0003490412 1.169401e-01 2.155956e-01 7 45662059 45662214 156 + 1.857 1.931 0.248
ENSG00000164742 E014 39.8484855 0.0107716641 2.178368e-06 1.680246e-05 7 45664289 45664672 384 + 1.326 1.716 1.338
ENSG00000164742 E015 42.3611923 0.0153996690 1.233112e-01 2.246893e-01 7 45677869 45678063 195 + 1.686 1.576 -0.373
ENSG00000164742 E016 33.1492679 0.0147436098 4.331954e-01 5.756179e-01 7 45678166 45678263 98 + 1.549 1.496 -0.180
ENSG00000164742 E017 29.0947724 0.0007620514 2.303848e-01 3.629218e-01 7 45679709 45679793 85 + 1.500 1.433 -0.231
ENSG00000164742 E018 3.5051268 0.0046068271 1.924561e-01 3.168499e-01 7 45680361 45680642 282 + 0.511 0.720 0.924
ENSG00000164742 E019 0.5138669 0.0205519161 4.074623e-01 5.510287e-01 7 45684385 45684978 594 + 0.242 0.109 -1.395
ENSG00000164742 E020 24.3416630 0.0008888858 1.490546e-02 4.027433e-02 7 45684979 45685068 90 + 1.474 1.314 -0.554
ENSG00000164742 E021 44.3323268 0.0005835955 7.941267e-06 5.397321e-05 7 45685962 45686215 254 + 1.762 1.538 -0.762
ENSG00000164742 E022 31.0739779 0.0008649950 1.854454e-04 9.010995e-04 7 45686547 45686673 127 + 1.612 1.390 -0.763
ENSG00000164742 E023 29.5466928 0.0082206581 4.995091e-03 1.591472e-02 7 45703376 45703492 117 + 1.579 1.378 -0.694
ENSG00000164742 E024 38.0657614 0.0005951398 2.683728e-05 1.615071e-04 7 45703600 45703746 147 + 1.698 1.472 -0.772
ENSG00000164742 E025 37.6364573 0.0077518552 7.954141e-03 2.366084e-02 7 45704518 45704616 99 + 1.668 1.495 -0.589
ENSG00000164742 E026 35.9834200 0.0008750728 5.813861e-03 1.812313e-02 7 45708350 45708464 115 + 1.636 1.485 -0.516
ENSG00000164742 E027 37.4912999 0.0007450092 1.091207e-01 2.042503e-01 7 45710528 45710652 125 + 1.612 1.531 -0.279
ENSG00000164742 E028 1291.8021140 0.0030430552 2.443054e-01 3.792626e-01 7 45713693 45723116 9424 + 3.079 3.111 0.107