ENSG00000164741

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276297 ENSG00000164741 HEK293_OSMI2_2hA HEK293_TMG_2hB DLC1 protein_coding protein_coding 3.700782 3.385734 4.293565 0.2582358 0.0930128 0.3418087 2.0350325 2.5679811 1.84941389 0.06198805 0.05023247 -0.4713938 0.59321250 0.7649667 0.4310000 -0.3339667 4.482622e-05 4.482622e-05 FALSE TRUE
ENST00000358919 ENSG00000164741 HEK293_OSMI2_2hA HEK293_TMG_2hB DLC1 protein_coding protein_coding 3.700782 3.385734 4.293565 0.2582358 0.0930128 0.3418087 1.1710247 0.4174871 1.74965226 0.10370514 0.16685044 2.0413377 0.28371667 0.1225000 0.4085333 0.2860333 1.989824e-04 4.482622e-05 FALSE TRUE
ENST00000515225 ENSG00000164741 HEK293_OSMI2_2hA HEK293_TMG_2hB DLC1 protein_coding processed_transcript 3.700782 3.385734 4.293565 0.2582358 0.0930128 0.3418087 0.1121558 0.3354320 0.05275078 0.16953761 0.05275078 -2.4606965 0.03049583 0.0959000 0.0123000 -0.0836000 4.676362e-01 4.482622e-05   FALSE
MSTRG.31156.2 ENSG00000164741 HEK293_OSMI2_2hA HEK293_TMG_2hB DLC1 protein_coding   3.700782 3.385734 4.293565 0.2582358 0.0930128 0.3418087 0.2488831 0.0000000 0.55484293 0.00000000 0.29588440 5.8197778 0.06139583 0.0000000 0.1283333 0.1283333 2.181325e-01 4.482622e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164741 E001 75.8148777 0.0212648496 9.076915e-06 6.090940e-05 8 13083361 13083768 408 - 1.650 2.015 1.230
ENSG00000164741 E002 50.6604691 0.0115130544 1.108130e-04 5.715857e-04 8 13083769 13083862 94 - 1.539 1.821 0.956
ENSG00000164741 E003 180.0328366 0.0003208773 1.509111e-15 5.576292e-14 8 13083863 13085188 1326 - 2.131 2.337 0.687
ENSG00000164741 E004 54.3659928 0.0012569147 9.812081e-01 9.922861e-01 8 13085189 13085554 366 - 1.739 1.740 0.004
ENSG00000164741 E005 12.2579717 0.0014907438 8.708483e-01 9.209943e-01 8 13085555 13085576 22 - 1.127 1.115 -0.044
ENSG00000164741 E006 9.7782459 0.0018114462 1.694223e-01 2.874412e-01 8 13085577 13085592 16 - 0.946 1.092 0.539
ENSG00000164741 E007 30.4940617 0.0029701427 2.102536e-01 3.388402e-01 8 13085593 13085814 222 - 1.453 1.540 0.298
ENSG00000164741 E008 34.8578744 0.0070766602 7.753927e-01 8.553136e-01 8 13085815 13085931 117 - 1.567 1.554 -0.044
ENSG00000164741 E009 0.4031496 0.0268852274 2.003979e-01 3.267137e-01 8 13086232 13086289 58 - 0.000 0.218 13.171
ENSG00000164741 E010 44.2270910 0.0028140937 5.722195e-01 6.983616e-01 8 13086290 13086463 174 - 1.641 1.677 0.125
ENSG00000164741 E011 41.8071974 0.0005643063 3.379131e-01 4.817917e-01 8 13088487 13088704 218 - 1.656 1.609 -0.162
ENSG00000164741 E012 0.0000000       8 13088705 13088739 35 -      
ENSG00000164741 E013 41.2806039 0.0021941137 8.214974e-01 8.874421e-01 8 13090252 13090470 219 - 1.627 1.616 -0.038
ENSG00000164741 E014 26.1045902 0.0008557273 2.785633e-01 4.182357e-01 8 13091318 13091432 115 - 1.468 1.399 -0.239
ENSG00000164741 E015 38.1279384 0.0006184182 2.624677e-01 4.002553e-01 8 13092612 13092825 214 - 1.621 1.561 -0.203
ENSG00000164741 E016 24.6147077 0.0007865799 5.805739e-01 7.052874e-01 8 13094759 13094822 64 - 1.427 1.393 -0.120
ENSG00000164741 E017 25.3990073 0.0116819870 6.645922e-02 1.374869e-01 8 13094823 13094928 106 - 1.500 1.349 -0.521
ENSG00000164741 E018 15.0143453 0.0480963565 8.424558e-02 1.662092e-01 8 13094929 13094957 29 - 1.319 1.080 -0.850
ENSG00000164741 E019 32.2205746 0.0012396640 8.205585e-05 4.377336e-04 8 13095086 13095245 160 - 1.637 1.398 -0.819
ENSG00000164741 E020 0.0000000       8 13095454 13095685 232 -      
ENSG00000164741 E021 0.0000000       8 13095686 13096078 393 -      
ENSG00000164741 E022 35.4974614 0.0006158966 2.237391e-04 1.065153e-03 8 13098399 13098575 177 - 1.669 1.461 -0.709
ENSG00000164741 E023 123.2572717 0.0169201793 8.248190e-03 2.441326e-02 8 13099347 13100559 1213 - 2.177 2.006 -0.573
ENSG00000164741 E024 14.9596633 0.0174274537 8.294987e-02 1.641645e-01 8 13100560 13100605 46 - 1.292 1.114 -0.631
ENSG00000164741 E025 18.2175993 0.0330308865 1.394780e-01 2.473133e-01 8 13100606 13100688 83 - 1.365 1.196 -0.595
ENSG00000164741 E026 16.0322279 0.0051470998 8.208540e-01 8.870629e-01 8 13100689 13100770 82 - 1.238 1.220 -0.064
ENSG00000164741 E027 0.0000000       8 13100771 13100905 135 -      
ENSG00000164741 E028 15.1853727 0.0011596118 2.399059e-01 3.740282e-01 8 13102790 13102853 64 - 1.262 1.165 -0.341
ENSG00000164741 E029 16.5561123 0.0087916304 4.668015e-03 1.500613e-02 8 13110742 13110823 82 - 1.371 1.113 -0.909
ENSG00000164741 E030 14.6385837 0.0022498217 1.176740e-06 9.629385e-06 8 13115586 13115657 72 - 1.383 0.944 -1.571
ENSG00000164741 E031 0.1482932 0.0411123545 4.899686e-01   8 13116146 13116244 99 - 0.000 0.122 12.065
ENSG00000164741 E032 24.0185890 0.0009105958 7.690695e-05 4.134330e-04 8 13132944 13133474 531 - 1.526 1.253 -0.949
ENSG00000164741 E033 0.4804688 0.0222194752 5.634128e-01 6.908762e-01 8 13214267 13214574 308 - 0.218 0.122 -1.005
ENSG00000164741 E034 0.1515154 0.0423625432 4.888319e-01   8 13214575 13214774 200 - 0.123 0.000 -12.661
ENSG00000164741 E035 0.0000000       8 13214775 13214777 3 -      
ENSG00000164741 E036 0.3332198 0.0284508488 1.000000e+00   8 13276262 13276546 285 - 0.123 0.122 -0.005
ENSG00000164741 E037 0.1451727 0.0430214584 4.894159e-01   8 13276695 13276873 179 - 0.123 0.000 -12.654
ENSG00000164741 E038 0.0000000       8 13304577 13305268 692 -      
ENSG00000164741 E039 0.0000000       8 13305269 13305302 34 -      
ENSG00000164741 E040 0.0000000       8 13393553 13393693 141 -      
ENSG00000164741 E041 0.0000000       8 13401470 13401619 150 -      
ENSG00000164741 E042 0.0000000       8 13498859 13499048 190 -      
ENSG00000164741 E043 0.2214452 0.0404459408 4.859648e-01   8 13499049 13499704 656 - 0.000 0.122 12.076
ENSG00000164741 E044 0.2214452 0.0404459408 4.859648e-01   8 13499705 13499821 117 - 0.000 0.122 12.076
ENSG00000164741 E045 0.2214452 0.0404459408 4.859648e-01   8 13499822 13500196 375 - 0.000 0.122 12.076
ENSG00000164741 E046 0.0000000       8 13514602 13514887 286 -      
ENSG00000164741 E047 0.0000000       8 13515459 13515658 200 -      
ENSG00000164741 E048 0.0000000       8 13557657 13559388 1732 -      
ENSG00000164741 E049 0.0000000       8 13604537 13604610 74 -