ENSG00000164715

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297293 ENSG00000164715 HEK293_OSMI2_2hA HEK293_TMG_2hB LMTK2 protein_coding protein_coding 8.313249 6.40413 9.769139 0.2076391 0.3041648 0.6084539 7.090750 3.787052 9.604678 0.4648179 0.2355383 1.340359 0.8244083 0.5904333 0.9835667 0.3931333 3.144217e-10 5.817399e-18 FALSE TRUE
MSTRG.30268.4 ENSG00000164715 HEK293_OSMI2_2hA HEK293_TMG_2hB LMTK2 protein_coding   8.313249 6.40413 9.769139 0.2076391 0.3041648 0.6084539 1.050117 2.604294 0.000000 0.4256934 0.0000000 -8.030277 0.1568917 0.4075333 0.0000000 -0.4075333 5.817399e-18 5.817399e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164715 E001 7.5924563 0.0022208637 9.937906e-05 5.189378e-04 7 98106862 98106897 36 + 1.059 0.608 -1.776
ENSG00000164715 E002 14.5083669 0.0012559232 7.602793e-07 6.482117e-06 7 98106898 98106973 76 + 1.310 0.877 -1.572
ENSG00000164715 E003 12.7320667 0.0026893913 1.497927e-05 9.563178e-05 7 98106974 98106988 15 + 1.250 0.851 -1.458
ENSG00000164715 E004 17.5125939 0.0010419616 6.392240e-07 5.535705e-06 7 98106989 98107027 39 + 1.377 0.988 -1.390
ENSG00000164715 E005 28.4390358 0.0385180290 2.222342e-04 1.058893e-03 7 98107028 98107274 247 + 1.576 1.201 -1.302
ENSG00000164715 E006 4.6042602 0.0751072904 8.707905e-02 1.707167e-01 7 98107275 98107280 6 + 0.834 0.558 -1.156
ENSG00000164715 E007 0.1482932 0.0413080805 3.232837e-01   7 98126565 98126757 193 + 0.000 0.157 9.755
ENSG00000164715 E008 23.0146345 0.0136925128 2.857622e-03 9.846455e-03 7 98137315 98137442 128 + 1.443 1.225 -0.758
ENSG00000164715 E009 43.8225846 0.0028060745 3.944527e-07 3.560505e-06 7 98141397 98141541 145 + 1.724 1.475 -0.851
ENSG00000164715 E010 38.9846813 0.0013110631 2.913541e-10 4.752144e-09 7 98151382 98151455 74 + 1.700 1.366 -1.143
ENSG00000164715 E011 45.6497171 0.0005121147 4.960795e-10 7.768932e-09 7 98154758 98154876 119 + 1.753 1.467 -0.974
ENSG00000164715 E012 32.7151756 0.0102944842 9.785206e-07 8.133459e-06 7 98159338 98159425 88 + 1.626 1.278 -1.200
ENSG00000164715 E013 36.4090641 0.0006066569 6.462594e-10 9.933624e-09 7 98171541 98171674 134 + 1.669 1.341 -1.126
ENSG00000164715 E014 0.4762024 0.1536893791 8.738125e-01 9.228890e-01 7 98175727 98175805 79 + 0.172 0.157 -0.154
ENSG00000164715 E015 28.2769375 0.0007158315 4.170631e-04 1.839912e-03 7 98185051 98185135 85 + 1.519 1.341 -0.616
ENSG00000164715 E016 41.7457453 0.0006180388 6.065829e-05 3.347081e-04 7 98186877 98186998 122 + 1.680 1.516 -0.559
ENSG00000164715 E017 49.6022410 0.0004620813 3.779593e-07 3.424355e-06 7 98190728 98190877 150 + 1.764 1.560 -0.693
ENSG00000164715 E018 70.8142955 0.0149343808 4.122414e-07 3.708352e-06 7 98191614 98191889 276 + 1.946 1.630 -1.066
ENSG00000164715 E019 399.3037411 0.0054652343 3.787352e-09 5.044663e-08 7 98191890 98193980 2091 + 2.645 2.503 -0.471
ENSG00000164715 E020 167.1333907 0.0034074534 8.742714e-05 4.629587e-04 7 98193981 98194572 592 + 2.247 2.162 -0.285
ENSG00000164715 E021 49.5747771 0.0026042795 3.444625e-01 4.885450e-01 7 98203574 98203706 133 + 1.689 1.702 0.042
ENSG00000164715 E022 83.9872517 0.0003704112 1.506619e-01 2.625728e-01 7 98203944 98204186 243 + 1.915 1.923 0.030
ENSG00000164715 E023 766.5085609 0.0008406068 7.155920e-21 5.090753e-19 7 98205464 98208801 3338 + 2.782 2.984 0.671
ENSG00000164715 E024 256.0208316 0.0188615000 5.261225e-09 6.836706e-08 7 98208802 98209283 482 + 2.158 2.616 1.529
ENSG00000164715 E025 144.9965244 0.0222610301 5.611926e-10 8.715161e-09 7 98209284 98209638 355 + 1.848 2.401 1.852