ENSG00000164684

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327835 ENSG00000164684 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF704 protein_coding protein_coding 4.171914 1.999317 6.81067 0.2170489 0.2393249 1.763208 2.3586848 1.4765483 3.2821751 0.09110293 0.09008143 1.147075 0.60478333 0.7464667 0.48403333 -0.262433333 0.0017345 0.0017345 FALSE TRUE
ENST00000517986 ENSG00000164684 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF704 protein_coding processed_transcript 4.171914 1.999317 6.81067 0.2170489 0.2393249 1.763208 0.1457234 0.0000000 0.3780644 0.00000000 0.22247576 5.278224 0.03147083 0.0000000 0.05443333 0.054433333 0.4174423 0.0017345   FALSE
ENST00000519936 ENSG00000164684 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF704 protein_coding protein_coding 4.171914 1.999317 6.81067 0.2170489 0.2393249 1.763208 1.0544568 0.1960109 1.8861422 0.19601091 0.21674127 3.202274 0.22959167 0.0822000 0.27593333 0.193733333 0.1885699 0.0017345 FALSE FALSE
MSTRG.31718.5 ENSG00000164684 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF704 protein_coding   4.171914 1.999317 6.81067 0.2170489 0.2393249 1.763208 0.2840435 0.1579696 0.6021022 0.06735574 0.09779115 1.865572 0.06260000 0.0879000 0.08906667 0.001166667 0.9367584 0.0017345 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164684 E001 67.7435877 0.0398107933 2.207255e-06 1.700935e-05 8 80628451 80628823 373 - 1.555 2.081 1.775
ENSG00000164684 E002 107.3363941 0.0017422946 5.384433e-21 3.881525e-19 8 80628824 80629545 722 - 1.839 2.217 1.265
ENSG00000164684 E003 91.5200549 0.0016572777 4.227174e-05 2.422853e-04 8 80629546 80630420 875 - 1.865 2.055 0.637
ENSG00000164684 E004 139.7600078 0.0007890387 3.516111e-02 8.195192e-02 8 80630421 80632733 2313 - 2.141 2.096 -0.149
ENSG00000164684 E005 16.9690867 0.0027990854 2.599408e-03 9.062953e-03 8 80632734 80632873 140 - 1.309 1.046 -0.940
ENSG00000164684 E006 72.7878364 0.0257501172 1.062827e-02 3.028052e-02 8 80632874 80634341 1468 - 1.907 1.719 -0.636
ENSG00000164684 E007 142.1894734 0.0002302036 4.154788e-06 3.009874e-05 8 80634342 80636878 2537 - 2.175 2.057 -0.397
ENSG00000164684 E008 90.1054126 0.0043180696 7.406225e-04 3.045224e-03 8 80636879 80637722 844 - 1.866 2.049 0.614
ENSG00000164684 E009 72.8702073 0.0005498263 3.870533e-01 5.312022e-01 8 80637723 80638533 811 - 1.854 1.840 -0.047
ENSG00000164684 E010 38.3881917 0.0005928263 7.114526e-01 8.084075e-01 8 80638534 80638783 250 - 1.562 1.606 0.152
ENSG00000164684 E011 104.3659929 0.0004748024 1.009635e-01 1.919403e-01 8 80638784 80640355 1572 - 2.017 1.981 -0.120
ENSG00000164684 E012 18.8979358 0.0120563112 1.918793e-02 4.974472e-02 8 80640356 80640410 55 - 1.346 1.130 -0.762
ENSG00000164684 E013 19.0695536 0.0068452501 9.144309e-02 1.773870e-01 8 80640411 80640525 115 - 1.323 1.189 -0.472
ENSG00000164684 E014 89.1662173 0.0003523907 3.315292e-04 1.506855e-03 8 80640526 80641477 952 - 1.972 1.852 -0.402
ENSG00000164684 E015 21.0213528 0.0026683324 1.307144e-01 2.351481e-01 8 80643035 80643129 95 - 1.354 1.252 -0.358
ENSG00000164684 E016 0.9159869 0.0158611890 3.842063e-01 5.283782e-01 8 80658668 80658830 163 - 0.323 0.170 -1.196
ENSG00000164684 E017 22.1496925 0.0025839101 3.580261e-03 1.195526e-02 8 80659585 80659689 105 - 1.410 1.188 -0.774
ENSG00000164684 E018 13.3595119 0.0212938534 1.830717e-01 3.050449e-01 8 80664815 80664841 27 - 1.185 1.046 -0.502
ENSG00000164684 E019 30.6073177 0.0045666053 4.348950e-02 9.745170e-02 8 80664842 80665066 225 - 1.524 1.398 -0.432
ENSG00000164684 E020 10.5923743 0.0440216349 9.804338e-01 9.917660e-01 8 80665067 80665082 16 - 1.038 1.064 0.092
ENSG00000164684 E021 14.3609299 0.0104012288 8.374933e-01 8.984118e-01 8 80670503 80670592 90 - 1.146 1.190 0.155
ENSG00000164684 E022 6.1657178 0.0026660807 8.069009e-01 8.773392e-01 8 80670593 80670603 11 - 0.842 0.830 -0.045
ENSG00000164684 E023 0.0000000       8 80673235 80673339 105 -      
ENSG00000164684 E024 26.0249771 0.0007312523 4.120240e-02 9.325660e-02 8 80687226 80687458 233 - 1.452 1.326 -0.436
ENSG00000164684 E025 18.6284468 0.0036653746 7.064037e-02 1.444043e-01 8 80693004 80693107 104 - 1.314 1.175 -0.490
ENSG00000164684 E026 0.0000000       8 80694225 80694308 84 -      
ENSG00000164684 E027 0.0000000       8 80814112 80814259 148 -      
ENSG00000164684 E028 32.6941551 0.0063646053 1.579184e-02 4.226671e-02 8 80821374 80821615 242 - 1.559 1.399 -0.550
ENSG00000164684 E029 20.2245833 0.0010660384 1.272104e-03 4.883997e-03 8 80873544 80873854 311 - 1.383 1.130 -0.889
ENSG00000164684 E030 0.4418608 0.0302079169 2.673074e-01 4.056115e-01 8 80874571 80874781 211 - 0.220 0.000 -9.207