ENSG00000164649

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373934 ENSG00000164649 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7L protein_coding protein_coding 16.25499 11.6094 19.95508 1.456127 1.156796 0.7809431 1.194026 0.3597179 2.1378500 0.1031064 0.4366577 2.5383964 0.06716250 0.0331000 0.1057000 0.0726000000 1.872266e-02 4.609083e-05 FALSE TRUE
ENST00000406877 ENSG00000164649 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7L protein_coding protein_coding 16.25499 11.6094 19.95508 1.456127 1.156796 0.7809431 7.446527 4.7920162 8.9095058 0.9343470 1.4682120 0.8933235 0.44731667 0.4210667 0.4463667 0.0253000000 9.399869e-01 4.609083e-05 FALSE TRUE
ENST00000465490 ENSG00000164649 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7L protein_coding processed_transcript 16.25499 11.6094 19.95508 1.456127 1.156796 0.7809431 1.040395 0.4938479 1.1650053 0.4938479 0.5826758 1.2216069 0.06230000 0.0437000 0.0600000 0.0163000000 6.460668e-01 4.609083e-05 FALSE TRUE
ENST00000488845 ENSG00000164649 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7L protein_coding retained_intron 16.25499 11.6094 19.95508 1.456127 1.156796 0.7809431 1.189799 2.7044776 0.2584173 1.1649609 0.0796868 -3.3381248 0.09674167 0.2154667 0.0133000 -0.2021666667 4.609083e-05 4.609083e-05 FALSE FALSE
MSTRG.29548.3 ENSG00000164649 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA7L protein_coding   16.25499 11.6094 19.95508 1.456127 1.156796 0.7809431 4.055009 2.7860148 4.8576121 0.6163604 1.0623172 0.7998422 0.25560833 0.2474333 0.2465667 -0.0008666667 1.000000e+00 4.609083e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164649 E001 1.0706228 0.0117522555 5.662948e-01 6.932881e-01 7 21900899 21900899 1 - 0.349 0.269 -0.527
ENSG00000164649 E002 1.0706228 0.0117522555 5.662948e-01 6.932881e-01 7 21900900 21900900 1 - 0.349 0.269 -0.527
ENSG00000164649 E003 320.7773389 0.0104276432 9.829631e-09 1.214026e-07 7 21900901 21901798 898 - 2.347 2.659 1.043
ENSG00000164649 E004 233.3503452 0.0002435203 6.629094e-03 2.026041e-02 7 21901799 21902352 554 - 2.322 2.429 0.357
ENSG00000164649 E005 3.4334009 0.0329124568 3.930305e-01 5.369122e-01 7 21902654 21902977 324 - 0.673 0.556 -0.515
ENSG00000164649 E006 90.0425189 0.0047838181 8.612502e-01 9.144810e-01 7 21902978 21903114 137 - 1.941 1.973 0.108
ENSG00000164649 E007 1.0308569 0.0179375333 1.804915e-02 4.723799e-02 7 21903759 21904109 351 - 0.436 0.000 -13.020
ENSG00000164649 E008 61.1031142 0.0004412341 4.049412e-01 5.486164e-01 7 21904110 21904149 40 - 1.787 1.794 0.024
ENSG00000164649 E009 91.1865083 0.0003683202 3.009582e-01 4.427367e-01 7 21904150 21904259 110 - 1.959 1.965 0.022
ENSG00000164649 E010 108.7044053 0.0006150152 5.355829e-01 6.673808e-01 7 21905506 21905631 126 - 2.025 2.048 0.075
ENSG00000164649 E011 1.8854297 0.0691070849 9.111923e-01 9.476014e-01 7 21905632 21905709 78 - 0.436 0.438 0.009
ENSG00000164649 E012 100.8915098 0.0003524054 9.134653e-01 9.491680e-01 7 21906289 21906456 168 - 1.986 2.027 0.138
ENSG00000164649 E013 80.6724893 0.0003485178 2.984002e-01 4.398342e-01 7 21906568 21906639 72 - 1.907 1.912 0.014
ENSG00000164649 E014 83.7082543 0.0004634759 1.048103e-01 1.978154e-01 7 21908130 21908200 71 - 1.931 1.912 -0.064
ENSG00000164649 E015 138.4781230 0.0007939913 4.885243e-02 1.071150e-01 7 21908201 21908366 166 - 2.147 2.128 -0.064
ENSG00000164649 E016 83.4416328 0.0008166922 6.290835e-02 1.315588e-01 7 21908367 21908420 54 - 1.933 1.902 -0.103
ENSG00000164649 E017 101.4604740 0.0002970725 1.190051e-03 4.607542e-03 7 21908421 21908507 87 - 2.033 1.963 -0.235
ENSG00000164649 E018 99.5666472 0.0008604139 5.973917e-07 5.205320e-06 7 21911617 21911751 135 - 2.052 1.905 -0.493
ENSG00000164649 E019 28.1137880 0.0237107891 2.593062e-03 9.044590e-03 7 21911752 21911754 3 - 1.551 1.292 -0.894
ENSG00000164649 E020 100.0234018 0.0003528861 3.933595e-09 5.223663e-08 7 21916754 21916894 141 - 2.062 1.891 -0.576
ENSG00000164649 E021 0.2924217 0.0290785164 3.621650e-01   7 21916895 21916897 3 - 0.174 0.000 -11.213
ENSG00000164649 E022 3.1333902 0.0050059817 9.339429e-01 9.623752e-01 7 21940262 21940315 54 - 0.598 0.646 0.210
ENSG00000164649 E023 0.1482932 0.0411597534 3.163776e-01   7 21944677 21944873 197 - 0.000 0.155 11.527
ENSG00000164649 E024 54.7811626 0.0004664012 6.647956e-07 5.736440e-06 7 21945781 21945903 123 - 1.814 1.611 -0.688