ENSG00000164620

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297164 ENSG00000164620 HEK293_OSMI2_2hA HEK293_TMG_2hB RELL2 protein_coding protein_coding 5.895959 10.18536 4.875948 0.9615361 0.1881432 -1.061203 0.2268673 0.0000000 0.2445262 0.00000000 0.24452620 4.6697423 0.05765833 0.0000000 0.04826667 0.048266667 0.709790071 0.009321732 FALSE TRUE
ENST00000444782 ENSG00000164620 HEK293_OSMI2_2hA HEK293_TMG_2hB RELL2 protein_coding protein_coding 5.895959 10.18536 4.875948 0.9615361 0.1881432 -1.061203 1.3730565 2.9469955 0.7058997 0.37145840 0.23467517 -2.0463026 0.20048333 0.2878000 0.14910000 -0.138700000 0.162775552 0.009321732 FALSE TRUE
ENST00000517794 ENSG00000164620 HEK293_OSMI2_2hA HEK293_TMG_2hB RELL2 protein_coding processed_transcript 5.895959 10.18536 4.875948 0.9615361 0.1881432 -1.061203 0.3758558 0.8447131 0.5282414 0.48500508 0.26922802 -0.6671870 0.06603333 0.0781000 0.10430000 0.026200000 0.949919065 0.009321732 FALSE FALSE
ENST00000518025 ENSG00000164620 HEK293_OSMI2_2hA HEK293_TMG_2hB RELL2 protein_coding processed_transcript 5.895959 10.18536 4.875948 0.9615361 0.1881432 -1.061203 1.0414784 1.4363783 0.7119958 0.22734010 0.13994556 -1.0023826 0.18880000 0.1408667 0.14703333 0.006166667 0.989576075 0.009321732 TRUE TRUE
ENST00000518856 ENSG00000164620 HEK293_OSMI2_2hA HEK293_TMG_2hB RELL2 protein_coding protein_coding 5.895959 10.18536 4.875948 0.9615361 0.1881432 -1.061203 0.5663049 1.8134974 0.1346943 0.34750352 0.07248950 -3.6556283 0.07662083 0.1771000 0.02790000 -0.149200000 0.009321732 0.009321732 FALSE TRUE
MSTRG.27074.10 ENSG00000164620 HEK293_OSMI2_2hA HEK293_TMG_2hB RELL2 protein_coding   5.895959 10.18536 4.875948 0.9615361 0.1881432 -1.061203 1.8007674 2.7412835 2.0730640 0.34693081 0.11143000 -0.4013976 0.31007917 0.2765000 0.42750000 0.151000000 0.201731537 0.009321732 FALSE TRUE
MSTRG.27074.7 ENSG00000164620 HEK293_OSMI2_2hA HEK293_TMG_2hB RELL2 protein_coding   5.895959 10.18536 4.875948 0.9615361 0.1881432 -1.061203 0.3022704 0.3671877 0.1836155 0.09394596 0.02063078 -0.9620882 0.05560000 0.0360000 0.03786667 0.001866667 1.000000000 0.009321732 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164620 E001 0.4428904 0.2772393155 7.021493e-01 0.8010169722 5 141636932 141636949 18 + 0.001 0.151 7.814
ENSG00000164620 E002 3.2504437 0.0067148267 6.052842e-01 0.7257089517 5 141636950 141636996 47 + 0.493 0.582 0.418
ENSG00000164620 E003 3.6901144 0.0049155328 5.717233e-01 0.6979672758 5 141636997 141637004 8 + 0.671 0.582 -0.389
ENSG00000164620 E004 6.5782964 0.0472208156 2.541811e-01 0.3908254954 5 141637005 141637011 7 + 0.924 0.758 -0.643
ENSG00000164620 E005 55.5941626 0.0006066405 2.949661e-02 0.0709601925 5 141637012 141637436 425 + 1.755 1.644 -0.375
ENSG00000164620 E006 16.2215799 0.0125311491 7.003665e-01 0.7998742243 5 141637437 141637441 5 + 1.183 1.147 -0.127
ENSG00000164620 E007 55.0998645 0.0031331821 9.074564e-01 0.9452521152 5 141637442 141637650 209 + 1.675 1.670 -0.019
ENSG00000164620 E008 40.8525542 0.0134601718 1.983659e-01 0.3241736054 5 141637651 141637741 91 + 1.461 1.574 0.385
ENSG00000164620 E009 9.6402078 0.0104475089 9.664263e-02 0.1853271783 5 141637742 141637748 7 + 1.100 0.906 -0.718
ENSG00000164620 E010 7.5932111 0.0023101458 2.299932e-02 0.0577465739 5 141637749 141637757 9 + 1.062 0.794 -1.013
ENSG00000164620 E011 21.1199060 0.0009803072 1.144538e-02 0.0322240605 5 141637758 141638169 412 + 1.411 1.212 -0.696
ENSG00000164620 E012 65.3861836 0.0003807315 4.976442e-02 0.1087433339 5 141638170 141638409 240 + 1.815 1.723 -0.309
ENSG00000164620 E013 62.4478294 0.0006058805 6.184423e-01 0.7360672884 5 141638795 141638860 66 + 1.713 1.736 0.080
ENSG00000164620 E014 54.1571926 0.0004970856 7.271531e-01 0.8199673830 5 141638955 141639021 67 + 1.680 1.661 -0.065
ENSG00000164620 E015 96.1330356 0.0003462491 1.006181e-01 0.1913970038 5 141639464 141639649 186 + 1.858 1.924 0.221
ENSG00000164620 E016 3.1761258 0.1457335337 1.865282e-02 0.0485698635 5 141639650 141639919 270 + 0.895 0.381 -2.285
ENSG00000164620 E017 134.0755846 0.0006386311 6.823319e-01 0.7857908252 5 141639920 141640295 376 + 2.048 2.061 0.044
ENSG00000164620 E018 50.3648152 0.0005174106 5.740064e-01 0.6998886339 5 141640412 141640445 34 + 1.613 1.644 0.103
ENSG00000164620 E019 9.2455070 0.0171254755 9.322054e-01 0.9613064036 5 141640446 141640670 225 + 0.923 0.940 0.063
ENSG00000164620 E020 83.2042776 0.0005262136 7.770775e-05 0.0004172406 5 141640671 141641524 854 + 1.708 1.889 0.610