ENSG00000164619

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000444773 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding nonsense_mediated_decay 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.037632596 0.00000000 0.25186887 0.00000000 0.25186887 4.710773 0.04260000 0.00000000 0.16460000 0.16460000 0.904363566 0.009458693 FALSE TRUE
ENST00000448280 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding processed_transcript 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.022455561 0.07301515 0.00000000 0.07301515 0.00000000 -3.053375 0.03250833 0.09103333 0.00000000 -0.09103333 0.635977793 0.009458693 TRUE FALSE
ENST00000476525 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding processed_transcript 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.060698419 0.00000000 0.16524134 0.00000000 0.16524134 4.131271 0.04498750 0.00000000 0.10953333 0.10953333 0.899276770 0.009458693 FALSE FALSE
ENST00000496609 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding retained_intron 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.010087579 0.04205381 0.00000000 0.04205381 0.00000000 -2.380004 0.02014167 0.05080000 0.00000000 -0.05080000 0.597079191 0.009458693 FALSE FALSE
ENST00000647703 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding processed_transcript 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.008544448 0.06835559 0.00000000 0.06835559 0.00000000 -2.970036 0.01031667 0.08253333 0.00000000 -0.08253333 0.630201253 0.009458693 FALSE TRUE
ENST00000648305 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding nonsense_mediated_decay 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.024593334 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.07235000 0.00000000 0.00000000 0.00000000   0.009458693 FALSE TRUE
ENST00000648392 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding protein_coding 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.043282888 0.08638145 0.00000000 0.08638145 0.00000000 -3.268756 0.05152500 0.14083333 0.00000000 -0.14083333 0.674974427 0.009458693 FALSE TRUE
ENST00000648445 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding protein_coding 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.052326986 0.00000000 0.31324512 0.00000000 0.15834460 5.014557 0.05977917 0.00000000 0.26063333 0.26063333 0.312343541 0.009458693 FALSE TRUE
ENST00000648618 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding nonsense_mediated_decay 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.055256689 0.00000000 0.09312039 0.00000000 0.09312039 3.366258 0.10526250 0.00000000 0.09076667 0.09076667 0.928316188 0.009458693 FALSE TRUE
ENST00000648848 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding protein_coding 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.027026825 0.12457567 0.00000000 0.06461056 0.00000000 -3.750346 0.04377917 0.15250000 0.00000000 -0.15250000 0.069497633 0.009458693 FALSE TRUE
ENST00000649002 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding nonsense_mediated_decay 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.018516921 0.00000000 0.14813537 0.00000000 0.14813537 3.983088 0.01227083 0.00000000 0.09816667 0.09816667 0.896750359 0.009458693 TRUE TRUE
ENST00000649985 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding nonsense_mediated_decay 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.043943679 0.21388924 0.00000000 0.08632979 0.00000000 -4.484713 0.08370000 0.30376667 0.00000000 -0.30376667 0.009458693 0.009458693 FALSE TRUE
ENST00000650202 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding nonsense_mediated_decay 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.090662097 0.09025099 0.33730014 0.09025099 0.17340291 1.792566 0.12495417 0.11253333 0.24120000 0.12866667 0.524349985 0.009458693 FALSE TRUE
ENST00000650350 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding nonsense_mediated_decay 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.024141545 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.05080417 0.00000000 0.00000000 0.00000000   0.009458693 FALSE TRUE
ENST00000650544 ENSG00000164619 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPER protein_coding protein_coding 0.6843268 0.7478341 1.355015 0.06765769 0.164565 0.8489628 0.081957196 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.11460833 0.00000000 0.00000000 0.00000000   0.009458693 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164619 E001 0.1817044 0.043798769 0.36160120   7 33904308 33904542 235 + 0.000 0.142 12.967
ENSG00000164619 E002 1.3116715 0.663663788 0.06027224 0.12707437 7 33904911 33905144 234 + 0.000 0.580 15.832
ENSG00000164619 E003 0.2934659 0.028888401 0.82204625   7 33905474 33905502 29 + 0.105 0.142 0.499
ENSG00000164619 E004 0.5149111 0.020110780 0.40171917 0.54541917 7 33905503 33905521 19 + 0.105 0.249 1.502
ENSG00000164619 E005 0.5149111 0.020110780 0.40171917 0.54541917 7 33905522 33905532 11 + 0.105 0.249 1.502
ENSG00000164619 E006 0.5149111 0.020110780 0.40171917 0.54541917 7 33905533 33905538 6 + 0.105 0.249 1.502
ENSG00000164619 E007 0.6600838 0.030591569 0.75893209 0.84341702 7 33905539 33905544 6 + 0.189 0.249 0.503
ENSG00000164619 E008 0.8052565 0.196267502 0.99579650 1.00000000 7 33905545 33905557 13 + 0.260 0.249 -0.076
ENSG00000164619 E009 0.8052565 0.196267502 0.99579650 1.00000000 7 33905558 33905562 5 + 0.260 0.249 -0.076
ENSG00000164619 E010 1.2502378 0.114275545 0.83030402 0.89352377 7 33905563 33905583 21 + 0.374 0.334 -0.240
ENSG00000164619 E011 0.8836199 0.134676315 0.67614847 0.78120094 7 33905584 33905585 2 + 0.321 0.246 -0.518
ENSG00000164619 E012 2.8431466 0.005541216 0.43643944 0.57850967 7 33905586 33905670 85 + 0.632 0.522 -0.499
ENSG00000164619 E013 3.9084588 0.003995769 0.13923724 0.24701119 7 33905671 33905746 76 + 0.773 0.569 -0.861
ENSG00000164619 E014 0.0000000       7 33905817 33905896 80 +      
ENSG00000164619 E015 0.0000000       7 33905897 33905905 9 +      
ENSG00000164619 E016 0.0000000       7 33905906 33905909 4 +      
ENSG00000164619 E017 0.0000000       7 33905910 33905953 44 +      
ENSG00000164619 E018 0.0000000       7 33905954 33906246 293 +      
ENSG00000164619 E019 0.0000000       7 33906247 33906817 571 +      
ENSG00000164619 E020 2.5474906 0.006251055 0.36572108 0.51001219 7 33906818 33906870 53 + 0.603 0.468 -0.636
ENSG00000164619 E021 2.1056298 0.012048499 0.78091434 0.85923315 7 33906871 33906881 11 + 0.504 0.468 -0.176
ENSG00000164619 E022 2.9076771 0.005746056 0.85480248 0.91018303 7 33906882 33906903 22 + 0.572 0.613 0.180
ENSG00000164619 E023 0.1817044 0.043798769 0.36160120   7 33921778 33922028 251 + 0.000 0.142 12.978
ENSG00000164619 E024 4.6251466 0.003956661 0.62825675 0.74382769 7 33937289 33937388 100 + 0.773 0.721 -0.209
ENSG00000164619 E025 0.0000000       7 33937389 33937560 172 +      
ENSG00000164619 E026 0.0000000       7 33939952 33940021 70 +      
ENSG00000164619 E027 0.0000000       7 33944192 33944308 117 +      
ENSG00000164619 E028 4.1091888 0.006413304 0.86962159 0.92015862 7 33966479 33966561 83 + 0.684 0.721 0.154
ENSG00000164619 E029 5.8023327 0.004620082 0.45100088 0.59200662 7 33970329 33970419 91 + 0.863 0.781 -0.321
ENSG00000164619 E030 6.0633203 0.003273959 0.13579996 0.24221070 7 33974702 33974784 83 + 0.924 0.752 -0.669
ENSG00000164619 E031 0.6997360 0.016696730 0.01728833 0.04558227 7 33976998 33977086 89 + 0.000 0.406 14.977
ENSG00000164619 E032 0.1817044 0.043798769 0.36160120   7 33977087 33977115 29 + 0.000 0.142 12.978
ENSG00000164619 E033 0.0000000       7 34019855 34019930 76 +      
ENSG00000164619 E034 0.0000000       7 34042676 34042969 294 +      
ENSG00000164619 E035 4.3030861 0.004227753 0.68909446 0.79104458 7 34046306 34046374 69 + 0.684 0.752 0.280
ENSG00000164619 E036 3.9385446 0.012827816 0.72621144 0.81928098 7 34046375 34046405 31 + 0.659 0.721 0.262
ENSG00000164619 E037 5.6474838 0.005744422 0.15131598 0.26346061 7 34051861 34051970 110 + 0.894 0.721 -0.683
ENSG00000164619 E038 4.1882187 0.017466544 0.72595260 0.81910116 7 34055163 34055209 47 + 0.730 0.688 -0.174
ENSG00000164619 E039 5.2273904 0.003589549 0.60095692 0.72213404 7 34055210 34055303 94 + 0.752 0.833 0.321
ENSG00000164619 E040 5.4122152 0.004484377 0.28915572 0.42982999 7 34058059 34058163 105 + 0.730 0.880 0.589
ENSG00000164619 E041 3.5207444 0.066948610 0.21025389 0.33884025 7 34062002 34062047 46 + 0.539 0.754 0.928
ENSG00000164619 E042 0.0000000       7 34067232 34067301 70 +      
ENSG00000164619 E043 5.9605390 0.002939529 0.43656259 0.57863916 7 34078857 34078984 128 + 0.792 0.901 0.423
ENSG00000164619 E044 6.9770990 0.002600535 0.80668482 0.87718484 7 34078985 34079186 202 + 0.879 0.922 0.164
ENSG00000164619 E045 10.2551219 0.035202837 0.94663713 0.97049277 7 34085756 34086092 337 + 1.036 1.060 0.087
ENSG00000164619 E046 6.0986916 0.047269035 0.79779183 0.87099252 7 34143230 34143360 131 + 0.863 0.833 -0.117
ENSG00000164619 E047 2.3174240 0.240428980 0.99512832 1.00000000 7 34153092 34153098 7 + 0.539 0.515 -0.115
ENSG00000164619 E048 6.3858398 0.004721818 0.73803921 0.82802896 7 34153099 34153410 312 + 0.846 0.901 0.211
ENSG00000164619 E049 11.5679065 0.001703013 0.23037437 0.36290845 7 34153411 34153909 499 + 1.142 1.044 -0.353
ENSG00000164619 E050 6.6158934 0.002802982 0.90732411 0.94515069 7 34153910 34154019 110 + 0.879 0.880 0.004
ENSG00000164619 E051 10.4490911 0.024295629 0.37678132 0.52109863 7 34154020 34154400 381 + 0.989 1.116 0.463
ENSG00000164619 E052 2.5745580 0.008528098 0.90922374 0.94633858 7 34154401 34154406 6 + 0.539 0.569 0.139
ENSG00000164619 E053 2.9442964 0.008214318 0.51914381 0.65327292 7 34154407 34154451 45 + 0.539 0.652 0.502
ENSG00000164619 E054 1.6877304 0.263043214 0.85906441 0.91306708 7 34154452 34154458 7 + 0.420 0.459 0.204
ENSG00000164619 E055 1.5394372 0.221786436 0.97197292 0.98647477 7 34154459 34154460 2 + 0.420 0.402 -0.102
ENSG00000164619 E056 1.5394372 0.221786436 0.97197292 0.98647477 7 34154461 34154465 5 + 0.420 0.402 -0.102
ENSG00000164619 E057 1.3911441 0.186578450 0.73645826 0.82694086 7 34154466 34154470 5 + 0.421 0.333 -0.502
ENSG00000164619 E058 1.3911441 0.186578450 0.73645826 0.82694086 7 34154471 34154475 5 + 0.421 0.333 -0.502
ENSG00000164619 E059 1.2459714 0.099186802 0.82909401 0.89265042 7 34154476 34154476 1 + 0.374 0.334 -0.238
ENSG00000164619 E060 1.2459714 0.099186802 0.82909401 0.89265042 7 34154477 34154486 10 + 0.374 0.334 -0.238
ENSG00000164619 E061 0.1482932 0.041395960 0.36447074   7 34154487 34154489 3 + 0.000 0.142 12.974
ENSG00000164619 E062 0.1482932 0.041395960 0.36447074   7 34154490 34154525 36 + 0.000 0.142 12.974
ENSG00000164619 E063 0.1451727 0.042953082 0.65005532   7 34154526 34154682 157 + 0.105 0.000 -12.249
ENSG00000164619 E064 0.5858876 0.019261013 0.47824465 0.61668424 7 34154683 34155872 1190 + 0.260 0.142 -1.085
ENSG00000164619 E065 0.0000000       7 34155873 34156347 475 +      
ENSG00000164619 E066 0.0000000       7 34156348 34156356 9 +      
ENSG00000164619 E067 0.1472490 0.043556550 0.64939366   7 34156357 34156427 71 + 0.105 0.000 -12.249