ENSG00000164611

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352433 ENSG00000164611 HEK293_OSMI2_2hA HEK293_TMG_2hB PTTG1 protein_coding protein_coding 212.6645 334.8532 153.8254 57.55677 1.00663 -1.122185 205.0779 327.9031 142.6594 57.36166 0.8656516 -1.200638 0.9584042 0.9782 0.9274667 -0.05073333 3.354456e-07 7.895653e-12 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164611 E001 109.6535547 1.761289e-02 2.111725e-01 3.398951e-01 5 160421855 160421857 3 + 2.062 1.944 -0.395
ENSG00000164611 E002 289.5122627 3.937558e-03 9.008388e-02 1.752654e-01 5 160421858 160421868 11 + 2.454 2.378 -0.253
ENSG00000164611 E003 647.9238133 7.074890e-04 1.184684e-01 2.177436e-01 5 160421869 160421891 23 + 2.775 2.741 -0.113
ENSG00000164611 E004 0.3697384 2.507230e-02 6.247863e-01 7.410434e-01 5 160421904 160421909 6 + 0.000 0.146 8.602
ENSG00000164611 E005 43.3376876 3.761806e-03 2.946116e-06 2.208153e-05 5 160421910 160422155 246 + 1.784 1.493 -0.991
ENSG00000164611 E006 23.9235809 1.196529e-02 1.319555e-02 3.636474e-02 5 160422156 160422206 51 + 1.494 1.264 -0.799
ENSG00000164611 E007 69.5053346 3.847377e-03 9.314339e-01 9.608089e-01 5 160422207 160422236 30 + 1.784 1.792 0.026
ENSG00000164611 E008 20.8077803 2.281033e-02 2.867156e-01 4.271307e-01 5 160422237 160422301 65 + 1.367 1.236 -0.456
ENSG00000164611 E009 986.0642584 3.603128e-04 2.451440e-01 3.802040e-01 5 160422302 160422339 38 + 2.947 2.928 -0.064
ENSG00000164611 E010 1486.8409974 6.871874e-05 7.011537e-01 8.004161e-01 5 160422340 160422403 64 + 3.115 3.114 -0.002
ENSG00000164611 E011 10.5591445 6.776064e-03 3.121374e-17 1.429035e-15 5 160422404 160422708 305 + 1.479 0.579 -3.380
ENSG00000164611 E012 2444.6577345 8.586967e-05 4.184131e-01 5.616761e-01 5 160422709 160422893 185 + 3.323 3.331 0.028
ENSG00000164611 E013 4.1718506 3.781960e-03 7.281700e-09 9.202776e-08 5 160422894 160423003 110 + 1.102 0.301 -3.542
ENSG00000164611 E014 1606.0704019 8.327678e-04 4.142837e-02 9.367740e-02 5 160424237 160424330 94 + 3.120 3.148 0.092
ENSG00000164611 E015 9.9650684 5.775295e-03 4.762958e-25 5.240000e-23 5 160424331 160424777 447 + 1.516 0.342 -4.727
ENSG00000164611 E016 1709.4186797 2.686958e-04 1.846264e-03 6.747091e-03 5 160427715 160427873 159 + 3.145 3.180 0.118
ENSG00000164611 E017 944.5423883 1.388831e-04 5.633730e-01 6.908584e-01 5 160428602 160428739 138 + 2.909 2.921 0.038