ENSG00000164609

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297151 ENSG00000164609 HEK293_OSMI2_2hA HEK293_TMG_2hB SLU7 protein_coding protein_coding 29.49902 12.60386 47.27259 1.196996 0.3987947 1.906299 9.019736 5.9840529 13.53058 0.3784382 0.8208693 1.175685 0.3344875 0.48143333 0.2862333 -0.19520000 0.005767161 0.0003923575 FALSE TRUE
ENST00000521190 ENSG00000164609 HEK293_OSMI2_2hA HEK293_TMG_2hB SLU7 protein_coding retained_intron 29.49902 12.60386 47.27259 1.196996 0.3987947 1.906299 7.467751 0.9218469 14.15167 0.5622456 1.3192564 3.925755 0.2059333 0.06926667 0.2990333 0.22976667 0.213673982 0.0003923575 FALSE TRUE
MSTRG.27263.2 ENSG00000164609 HEK293_OSMI2_2hA HEK293_TMG_2hB SLU7 protein_coding   29.49902 12.60386 47.27259 1.196996 0.3987947 1.906299 11.923815 5.1222356 17.62443 0.3626093 0.6006671 1.780736 0.4280917 0.40886667 0.3730000 -0.03586667 0.610739972 0.0003923575 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164609 E001 294.9567051 0.0004573132 1.543389e-05 9.821977e-05 5 160401641 160403152 1512 - 2.407 2.507 0.330
ENSG00000164609 E002 207.8454226 0.0002323903 1.648697e-04 8.130061e-04 5 160403153 160403464 312 - 2.256 2.354 0.326
ENSG00000164609 E003 152.1764678 0.0008054945 4.753967e-02 1.048027e-01 5 160404440 160404556 117 - 2.136 2.200 0.216
ENSG00000164609 E004 1.1009004 0.0136671601 3.767724e-01 5.210939e-01 5 160404557 160404619 63 - 0.350 0.180 -1.268
ENSG00000164609 E005 122.5132377 0.0074950476 1.482703e-01 2.593234e-01 5 160404809 160404880 72 - 2.040 2.114 0.247
ENSG00000164609 E006 187.4466288 0.0056193438 1.019266e-01 1.934354e-01 5 160405031 160405135 105 - 2.223 2.294 0.237
ENSG00000164609 E007 0.1472490 0.0429851140 1.000000e+00   5 160406349 160406364 16 - 0.081 0.000 -9.026
ENSG00000164609 E008 0.5889961 0.9269011801 6.586607e-01 7.676959e-01 5 160406365 160406467 103 - 0.261 0.000 -11.029
ENSG00000164609 E009 234.1102046 0.0001808373 8.288314e-02 1.640611e-01 5 160406468 160406629 162 - 2.328 2.371 0.143
ENSG00000164609 E010 210.7540964 0.0002013595 1.442621e-01 2.538071e-01 5 160407476 160407615 140 - 2.284 2.322 0.128
ENSG00000164609 E011 1.6284995 0.0082739908 1.264056e-02 3.506327e-02 5 160407616 160407745 130 - 0.514 0.000 -12.485
ENSG00000164609 E012 147.4162606 0.0002212457 8.418777e-01 9.014062e-01 5 160407746 160407813 68 - 2.144 2.139 -0.019
ENSG00000164609 E013 184.0397963 0.0004527970 7.931952e-01 8.677803e-01 5 160407971 160408068 98 - 2.233 2.241 0.028
ENSG00000164609 E014 201.3964286 0.0002161862 8.355631e-01 8.971601e-01 5 160408329 160408460 132 - 2.275 2.281 0.021
ENSG00000164609 E015 143.3736789 0.0002638216 4.040182e-01 5.477410e-01 5 160408650 160408697 48 - 2.140 2.114 -0.088
ENSG00000164609 E016 159.8090538 0.0002549554 4.273777e-01 5.702272e-01 5 160412451 160412519 69 - 2.187 2.164 -0.079
ENSG00000164609 E017 199.3593537 0.0016217033 5.290796e-01 6.619242e-01 5 160413456 160413594 139 - 2.280 2.261 -0.065
ENSG00000164609 E018 107.7370679 0.0013882403 1.234859e-01 2.249232e-01 5 160413595 160413620 26 - 2.028 1.966 -0.208
ENSG00000164609 E019 0.6998377 0.0174053170 3.736590e-01 5.180691e-01 5 160413802 160413898 97 - 0.150 0.307 1.317
ENSG00000164609 E020 111.8220607 0.0003183403 1.861416e-01 3.089122e-01 5 160413899 160413931 33 - 2.039 1.991 -0.161
ENSG00000164609 E021 118.3463934 0.0002544494 2.096891e-01 3.381799e-01 5 160413932 160413979 48 - 2.062 2.018 -0.147
ENSG00000164609 E022 0.0000000       5 160414117 160414318 202 -      
ENSG00000164609 E023 95.2319019 0.0004869748 5.774858e-02 1.227688e-01 5 160414319 160414337 19 - 1.977 1.901 -0.256
ENSG00000164609 E024 170.5973776 0.0023477175 9.224719e-03 2.684561e-02 5 160414338 160414472 135 - 2.234 2.138 -0.321
ENSG00000164609 E025 196.6007439 0.0013864000 4.519667e-07 4.032348e-06 5 160415125 160415310 186 - 2.314 2.148 -0.555
ENSG00000164609 E026 7.2570344 0.0217925903 1.631862e-03 6.062742e-03 5 160417112 160417241 130 - 1.003 0.486 -2.140
ENSG00000164609 E027 3.3237041 0.0048195937 6.200095e-01 7.372887e-01 5 160418596 160418685 90 - 0.634 0.552 -0.362
ENSG00000164609 E028 3.0397014 0.0055640894 8.196681e-01 8.861432e-01 5 160418686 160419022 337 - 0.590 0.552 -0.169
ENSG00000164609 E029 99.5712524 0.0009528298 3.437615e-05 2.014246e-04 5 160419023 160419081 59 - 2.024 1.850 -0.586
ENSG00000164609 E030 0.1451727 0.0425077915 1.000000e+00   5 160421591 160421711 121 - 0.081 0.000 -9.025