ENSG00000164597

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297135 ENSG00000164597 HEK293_OSMI2_2hA HEK293_TMG_2hB COG5 protein_coding protein_coding 11.92882 2.797035 18.81917 0.157545 0.922482 2.74585 3.2158082 1.6469542 4.9308936 0.06752931 0.75092254 1.576238 0.40522917 0.59373333 0.26226667 -0.33146667 8.747969e-04 1.415223e-10 FALSE TRUE
ENST00000347053 ENSG00000164597 HEK293_OSMI2_2hA HEK293_TMG_2hB COG5 protein_coding protein_coding 11.92882 2.797035 18.81917 0.157545 0.922482 2.74585 1.1778840 0.2684978 1.9341361 0.26849782 0.36732578 2.803391 0.08378333 0.08720000 0.10316667 0.01596667 5.155997e-01 1.415223e-10 FALSE TRUE
ENST00000393603 ENSG00000164597 HEK293_OSMI2_2hA HEK293_TMG_2hB COG5 protein_coding protein_coding 11.92882 2.797035 18.81917 0.157545 0.922482 2.74585 0.4601499 0.2007684 0.4443221 0.02273210 0.06957996 1.108057 0.07182500 0.07256667 0.02336667 -0.04920000 9.907571e-03 1.415223e-10 FALSE TRUE
ENST00000605888 ENSG00000164597 HEK293_OSMI2_2hA HEK293_TMG_2hB COG5 protein_coding protein_coding 11.92882 2.797035 18.81917 0.157545 0.922482 2.74585 1.6793665 0.0000000 3.2874311 0.00000000 0.26896104 8.365199 0.08015417 0.00000000 0.17623333 0.17623333 1.415223e-10 1.415223e-10 FALSE FALSE
MSTRG.30487.3 ENSG00000164597 HEK293_OSMI2_2hA HEK293_TMG_2hB COG5 protein_coding   11.92882 2.797035 18.81917 0.157545 0.922482 2.74585 4.5681360 0.6808149 7.4775217 0.21060917 0.16906621 3.438117 0.32268750 0.24650000 0.39890000 0.15240000 2.707322e-01 1.415223e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164597 E001 11.7371424 0.0207787910 3.321949e-02 7.823636e-02 7 107201372 107201554 183 - 0.955 1.233 1.005
ENSG00000164597 E002 213.3513612 0.0081082042 5.199789e-06 3.685866e-05 7 107201555 107203429 1875 - 2.189 2.421 0.776
ENSG00000164597 E003 83.0199977 0.0003940328 7.747060e-05 4.160970e-04 7 107203430 107203630 201 - 1.795 1.988 0.650
ENSG00000164597 E004 22.7214973 0.0146598374 2.997106e-05 1.783885e-04 7 107207848 107210454 2607 - 1.167 1.573 1.411
ENSG00000164597 E005 2.9150786 0.0053095292 2.890331e-02 6.981013e-02 7 107210455 107210525 71 - 0.436 0.805 1.636
ENSG00000164597 E006 56.3100654 0.0018925783 2.953438e-01 4.364776e-01 7 107210526 107210605 80 - 1.661 1.744 0.281
ENSG00000164597 E007 78.2193849 0.0029163921 1.040189e-01 1.966242e-01 7 107211099 107211225 127 - 1.796 1.904 0.364
ENSG00000164597 E008 62.7452501 0.0014978274 1.069325e-01 2.010085e-01 7 107230615 107230691 77 - 1.700 1.808 0.366
ENSG00000164597 E009 68.8728989 0.0018275129 1.395562e-02 3.812054e-02 7 107236450 107236554 105 - 1.730 1.879 0.502
ENSG00000164597 E010 56.1540577 0.0007786495 1.162217e-01 2.145797e-01 7 107236555 107236654 100 - 1.652 1.760 0.366
ENSG00000164597 E011 34.4922473 0.0005847777 2.540441e-01 3.906755e-01 7 107236655 107236687 33 - 1.448 1.548 0.343
ENSG00000164597 E012 58.2312732 0.0004946445 4.543260e-01 5.949615e-01 7 107248396 107248499 104 - 1.682 1.744 0.213
ENSG00000164597 E013 0.0000000       7 107253048 107253076 29 -      
ENSG00000164597 E014 0.0000000       7 107253077 107253247 171 -      
ENSG00000164597 E015 44.2453234 0.0057351464 8.393182e-01 8.995859e-01 7 107256732 107256794 63 - 1.576 1.580 0.013
ENSG00000164597 E016 65.6648326 0.0003712708 1.315557e-01 2.363026e-01 7 107258273 107258383 111 - 1.758 1.700 -0.197
ENSG00000164597 E017 0.1515154 0.0431899380 1.000000e+00   7 107258384 107258479 96 - 0.063 0.000 -7.860
ENSG00000164597 E018 0.0000000       7 107258480 107258620 141 -      
ENSG00000164597 E019 60.9721621 0.0006372146 3.209004e-01 4.640695e-01 7 107281300 107281399 100 - 1.721 1.688 -0.111
ENSG00000164597 E020 75.2405554 0.0004013523 2.406974e-02 5.995661e-02 7 107283571 107283732 162 - 1.821 1.728 -0.314
ENSG00000164597 E021 90.2528609 0.0039786654 1.939514e-01 3.187577e-01 7 107298142 107298346 205 - 1.891 1.839 -0.177
ENSG00000164597 E022 63.5891508 0.0003945107 1.677591e-01 2.852786e-01 7 107324440 107324521 82 - 1.741 1.688 -0.179
ENSG00000164597 E023 39.7356483 0.0005750135 4.709185e-01 6.100943e-01 7 107362033 107362067 35 - 1.540 1.514 -0.090
ENSG00000164597 E024 42.1906371 0.0005503902 2.871869e-01 4.276598e-01 7 107362068 107362110 43 - 1.570 1.522 -0.164
ENSG00000164597 E025 61.0886662 0.0023936569 8.409438e-03 2.481144e-02 7 107362308 107362420 113 - 1.743 1.602 -0.477
ENSG00000164597 E026 63.6049756 0.0003915106 4.334891e-07 3.881793e-06 7 107372595 107372760 166 - 1.780 1.495 -0.969
ENSG00000164597 E027 45.2456878 0.0222023290 1.693395e-02 4.478691e-02 7 107412502 107412632 131 - 1.627 1.410 -0.743
ENSG00000164597 E028 0.2214452 0.0469994828 1.027335e-01   7 107480822 107480942 121 - 0.000 0.224 11.785
ENSG00000164597 E029 53.6158936 0.0004607900 1.252937e-04 6.380442e-04 7 107527237 107527357 121 - 1.700 1.476 -0.762
ENSG00000164597 E030 0.0000000       7 107547998 107548110 113 -      
ENSG00000164597 E031 52.8772534 0.0006151884 1.480341e-02 4.005302e-02 7 107548111 107548180 70 - 1.677 1.548 -0.440
ENSG00000164597 E032 57.6563741 0.0004147410 6.786957e-04 2.821091e-03 7 107548278 107548332 55 - 1.724 1.540 -0.625
ENSG00000164597 E033 0.0000000       7 107549211 107549259 49 -      
ENSG00000164597 E034 56.2336014 0.0004024193 1.556851e-03 5.819322e-03 7 107554285 107554342 58 - 1.710 1.540 -0.581
ENSG00000164597 E035 63.4606900 0.0003620051 1.832267e-05 1.146624e-04 7 107557976 107558115 140 - 1.771 1.540 -0.786
ENSG00000164597 E036 30.2808007 0.0018095988 5.865995e-01 7.101324e-01 7 107563803 107564261 459 - 1.423 1.402 -0.073