ENSG00000164542

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297063 ENSG00000164542 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0895 protein_coding protein_coding 6.930316 1.74404 10.95754 0.1417158 0.3342453 2.644486 0.5214329 0.00000000 0.2096317 0.00000000 0.1398177 4.457015 0.11663750 0.00000000 0.01880000 0.01880000 6.739143e-01 2.987718e-09 FALSE TRUE
ENST00000317020 ENSG00000164542 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0895 protein_coding protein_coding 6.930316 1.74404 10.95754 0.1417158 0.3342453 2.644486 1.6615413 0.00000000 2.6751874 0.00000000 0.2753320 8.068879 0.19974583 0.00000000 0.24570000 0.24570000 2.987718e-09 2.987718e-09 FALSE TRUE
ENST00000338533 ENSG00000164542 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0895 protein_coding protein_coding 6.930316 1.74404 10.95754 0.1417158 0.3342453 2.644486 0.8104138 0.76874017 1.5862489 0.14818977 0.1624216 1.035472 0.12910833 0.43353333 0.14593333 -0.28760000 1.265770e-04 2.987718e-09 FALSE TRUE
ENST00000415803 ENSG00000164542 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0895 protein_coding protein_coding 6.930316 1.74404 10.95754 0.1417158 0.3342453 2.644486 0.2442268 0.16576254 0.4148993 0.04036751 0.0946470 1.273494 0.06087500 0.09283333 0.03743333 -0.05540000 7.724261e-02 2.987718e-09 FALSE TRUE
ENST00000436884 ENSG00000164542 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0895 protein_coding protein_coding 6.930316 1.74404 10.95754 0.1417158 0.3342453 2.644486 0.7528318 0.02962282 1.2400723 0.01572289 0.1614740 4.979536 0.07145000 0.01680000 0.11306667 0.09626667 3.079777e-03 2.987718e-09 FALSE TRUE
ENST00000440378 ENSG00000164542 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0895 protein_coding protein_coding 6.930316 1.74404 10.95754 0.1417158 0.3342453 2.644486 1.1235700 0.67581556 1.9008116 0.12206508 0.1022389 1.478293 0.24473333 0.39836667 0.17333333 -0.22503333 3.371484e-02 2.987718e-09 FALSE TRUE
ENST00000453212 ENSG00000164542 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0895 protein_coding protein_coding 6.930316 1.74404 10.95754 0.1417158 0.3342453 2.644486 0.4033745 0.00000000 0.8960589 0.00000000 0.4481799 6.501533 0.03257500 0.00000000 0.07960000 0.07960000 4.599986e-01 2.987718e-09 FALSE TRUE
ENST00000483360 ENSG00000164542 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0895 protein_coding processed_transcript 6.930316 1.74404 10.95754 0.1417158 0.3342453 2.644486 0.6299672 0.00000000 0.7589201 0.00000000 0.2040975 6.264762 0.06221250 0.00000000 0.07043333 0.07043333 5.763070e-03 2.987718e-09 FALSE FALSE
ENST00000483526 ENSG00000164542 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0895 protein_coding processed_transcript 6.930316 1.74404 10.95754 0.1417158 0.3342453 2.644486 0.3296275 0.03256049 0.8862814 0.03256049 0.2419205 4.396365 0.03658333 0.01876667 0.08006667 0.06130000 1.719763e-01 2.987718e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164542 E001 1.7325925 0.0303052940 1.625839e-04 8.031141e-04 7 36324152 36324220 69 - 0.159 0.826 3.685
ENSG00000164542 E002 1.9540377 0.0077250209 1.990671e-05 1.235306e-04 7 36324221 36324222 2 - 0.159 0.872 3.864
ENSG00000164542 E003 2.3206556 0.0064938475 1.438482e-05 9.212513e-05 7 36324223 36324229 7 - 0.202 0.912 3.602
ENSG00000164542 E004 248.4999411 0.0014861091 1.124047e-21 8.628336e-20 7 36324230 36326495 2266 - 2.241 2.486 0.819
ENSG00000164542 E005 25.6849872 0.0008252629 8.022642e-01 8.740334e-01 7 36326496 36326565 70 - 1.336 1.338 0.009
ENSG00000164542 E006 35.3517776 0.0062917390 4.979352e-01 6.344695e-01 7 36326566 36326704 139 - 1.474 1.440 -0.118
ENSG00000164542 E007 54.0368472 0.0004120538 1.426729e-02 3.883416e-02 7 36326705 36326918 214 - 1.669 1.541 -0.436
ENSG00000164542 E008 35.4984911 0.0006204856 2.049320e-02 5.253126e-02 7 36330982 36331079 98 - 1.495 1.339 -0.541
ENSG00000164542 E009 0.0000000       7 36333855 36333855 1 -      
ENSG00000164542 E010 49.9982900 0.0004663004 3.169232e-03 1.076443e-02 7 36333856 36334042 187 - 1.643 1.473 -0.582
ENSG00000164542 E011 33.6560114 0.0006214756 2.854010e-03 9.835248e-03 7 36334043 36334134 92 - 1.483 1.260 -0.771
ENSG00000164542 E012 23.8111127 0.0009196950 1.255168e-03 4.827062e-03 7 36334135 36334161 27 - 1.347 1.043 -1.082
ENSG00000164542 E013 39.3431666 0.0005469243 1.324093e-04 6.694388e-04 7 36335046 36335178 133 - 1.554 1.277 -0.958
ENSG00000164542 E014 16.2532742 0.0038303281 1.150832e-01 2.129617e-01 7 36336154 36336297 144 - 1.173 1.014 -0.574
ENSG00000164542 E015 9.6562607 0.0038784685 9.554961e-07 7.958491e-06 7 36355196 36356146 951 - 0.769 1.323 2.041
ENSG00000164542 E016 3.8167592 0.0043067539 7.890883e-01 8.649914e-01 7 36356147 36356367 221 - 0.597 0.661 0.280
ENSG00000164542 E017 6.9961192 0.0039761311 7.640978e-02 1.537586e-01 7 36356368 36356901 534 - 0.758 1.014 0.980
ENSG00000164542 E018 16.7575882 0.0011559081 4.990077e-01 6.353620e-01 7 36356902 36356944 43 - 1.168 1.120 -0.171
ENSG00000164542 E019 37.6186629 0.0025561449 5.443671e-03 1.713642e-02 7 36356945 36357191 247 - 1.525 1.324 -0.694
ENSG00000164542 E020 40.5518297 0.0005807184 9.005475e-06 6.050503e-05 7 36357192 36357590 399 - 1.574 1.243 -1.144
ENSG00000164542 E021 4.1406070 0.0037246727 1.750870e-03 6.443223e-03 7 36366704 36366915 212 - 0.710 0.000 -12.569
ENSG00000164542 E022 20.3929100 0.0009187708 7.737423e-03 2.311863e-02 7 36366916 36367110 195 - 1.276 1.014 -0.937
ENSG00000164542 E023 14.7294549 0.0012457863 2.062147e-03 7.417973e-03 7 36367111 36367269 159 - 1.159 0.780 -1.420
ENSG00000164542 E024 0.0000000       7 36368200 36368357 158 -      
ENSG00000164542 E025 0.4460135 0.0303420163 7.464414e-01 8.342099e-01 7 36383859 36383928 70 - 0.159 0.000 -9.658
ENSG00000164542 E026 0.9307487 0.0686810144 1.000000e+00 1.000000e+00 7 36389967 36390125 159 - 0.240 0.235 -0.042