ENSG00000164466

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321442 ENSG00000164466 HEK293_OSMI2_2hA HEK293_TMG_2hB SFXN1 protein_coding protein_coding 75.40547 40.34265 121.4209 5.99894 2.863908 1.589401 27.473916 21.7626477 41.539169 6.0897490 1.8370362 0.9323028 0.40376250 0.52270000 0.34176667 -0.18093333 0.125785709 1.425249e-07 FALSE TRUE
ENST00000502393 ENSG00000164466 HEK293_OSMI2_2hA HEK293_TMG_2hB SFXN1 protein_coding protein_coding 75.40547 40.34265 121.4209 5.99894 2.863908 1.589401 10.342655 0.5803864 20.394424 0.5803864 0.9638728 5.1110788 0.09521667 0.01600000 0.16850000 0.15250000 0.040406742 1.425249e-07 FALSE TRUE
MSTRG.27338.4 ENSG00000164466 HEK293_OSMI2_2hA HEK293_TMG_2hB SFXN1 protein_coding   75.40547 40.34265 121.4209 5.99894 2.863908 1.589401 25.557868 9.4131883 45.858783 1.1762880 1.5938840 2.2832255 0.32521250 0.24350000 0.37750000 0.13400000 0.120237239 1.425249e-07 TRUE TRUE
MSTRG.27338.7 ENSG00000164466 HEK293_OSMI2_2hA HEK293_TMG_2hB SFXN1 protein_coding   75.40547 40.34265 121.4209 5.99894 2.863908 1.589401 4.769918 3.2343840 4.799608 0.8739564 0.3164018 0.5679748 0.06573333 0.07773333 0.03966667 -0.03806667 0.006502216 1.425249e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164466 E001 0.0000000       5 175477062 175477190 129 +      
ENSG00000164466 E002 0.6362506 0.5201950150 1.000000e+00 1.000000e+00 5 175478461 175478482 22 + 0.206 0.185 -0.191
ENSG00000164466 E003 0.7834997 0.1370786766 6.931978e-01 7.942552e-01 5 175478483 175478493 11 + 0.256 0.184 -0.603
ENSG00000164466 E004 1.5283913 0.1209466082 2.090594e-01 3.374085e-01 5 175478494 175478503 10 + 0.449 0.184 -1.774
ENSG00000164466 E005 3.1721025 0.0048720381 2.591647e-01 3.965398e-01 5 175478504 175478517 14 + 0.644 0.493 -0.690
ENSG00000164466 E006 40.3123487 0.0015483529 3.187472e-06 2.370670e-05 5 175478518 175478559 42 + 1.656 1.394 -0.899
ENSG00000164466 E007 42.0023590 0.0026900235 2.913571e-06 2.186269e-05 5 175478560 175478563 4 + 1.675 1.403 -0.932
ENSG00000164466 E008 43.8414911 0.0030905393 1.617308e-05 1.024589e-04 5 175478564 175478564 1 + 1.687 1.445 -0.827
ENSG00000164466 E009 44.2832502 0.0032143731 3.602298e-05 2.099054e-04 5 175478565 175478565 1 + 1.689 1.461 -0.778
ENSG00000164466 E010 70.1446640 0.0003676523 2.930315e-07 2.718074e-06 5 175478566 175478574 9 + 1.878 1.681 -0.666
ENSG00000164466 E011 142.4463901 0.0047815719 1.802807e-05 1.129830e-04 5 175478575 175478589 15 + 2.173 2.011 -0.544
ENSG00000164466 E012 142.4110163 0.0038159951 5.288208e-06 3.742380e-05 5 175478590 175478590 1 + 2.173 2.011 -0.543
ENSG00000164466 E013 145.4367988 0.0048356405 2.980428e-05 1.774906e-04 5 175478591 175478591 1 + 2.181 2.024 -0.526
ENSG00000164466 E014 231.0812832 0.0044733099 3.052807e-04 1.400876e-03 5 175478592 175478639 48 + 2.369 2.256 -0.377
ENSG00000164466 E015 4.4575992 0.0280678990 9.315893e-01 9.609064e-01 5 175478640 175478667 28 + 0.699 0.758 0.240
ENSG00000164466 E016 1.6500539 0.1190649965 8.806860e-01 9.274741e-01 5 175491494 175491651 158 + 0.415 0.409 -0.030
ENSG00000164466 E017 3.7225872 0.0126715087 9.384458e-01 9.653612e-01 5 175491652 175492094 443 + 0.624 0.673 0.209
ENSG00000164466 E018 490.1481272 0.0001364345 2.388499e-15 8.600912e-14 5 175492095 175492206 112 + 2.691 2.599 -0.305
ENSG00000164466 E019 482.4540055 0.0001283667 5.715786e-07 5.001102e-06 5 175492207 175492267 61 + 2.669 2.631 -0.125
ENSG00000164466 E020 0.7707125 0.0153787590 1.727131e-01 2.917312e-01 5 175492268 175492546 279 + 0.146 0.412 1.981
ENSG00000164466 E021 327.6543222 0.0001806514 5.702409e-02 1.214999e-01 5 175509032 175509060 29 + 2.487 2.497 0.036
ENSG00000164466 E022 666.0873527 0.0001682468 1.639195e-01 2.802586e-01 5 175509061 175509202 142 + 2.788 2.817 0.098
ENSG00000164466 E023 3.8460072 0.0040279241 5.609993e-03 1.757879e-02 5 175509203 175509403 201 + 0.764 0.313 -2.187
ENSG00000164466 E024 527.1226641 0.0012680273 5.854847e-01 7.091738e-01 5 175510109 175510207 99 + 2.676 2.734 0.195
ENSG00000164466 E025 0.8889039 0.3824680947 6.690531e-01 7.759561e-01 5 175510208 175510312 105 + 0.205 0.323 0.877
ENSG00000164466 E026 0.7415557 0.1097608075 6.513856e-01 7.622648e-01 5 175511436 175511450 15 + 0.256 0.183 -0.611
ENSG00000164466 E027 452.0714012 0.0030450496 8.699884e-01 9.203655e-01 5 175511451 175511526 76 + 2.612 2.659 0.154
ENSG00000164466 E028 0.5891098 0.0182727925 2.049159e-01 3.322979e-01 5 175511527 175511579 53 + 0.256 0.000 -11.286
ENSG00000164466 E029 457.0955506 0.0001449958 7.974711e-01 8.707745e-01 5 175512111 175512196 86 + 2.616 2.672 0.188
ENSG00000164466 E030 528.0366912 0.0001525548 1.498393e-01 2.614662e-01 5 175513463 175513590 128 + 2.688 2.715 0.090
ENSG00000164466 E031 10.2971076 0.0016587545 7.364954e-08 7.675166e-07 5 175513591 175513738 148 + 0.749 1.345 2.195
ENSG00000164466 E032 404.3387382 0.0001637951 7.801698e-05 4.186399e-04 5 175516614 175516663 50 + 2.590 2.564 -0.085
ENSG00000164466 E033 1.6432613 0.0890240088 1.971676e-02 5.088990e-02 5 175521886 175521918 33 + 0.507 0.000 -12.750
ENSG00000164466 E034 391.9949015 0.0002922728 3.988071e-04 1.769784e-03 5 175521919 175521968 50 + 2.574 2.551 -0.076
ENSG00000164466 E035 424.8214167 0.0001420664 2.256020e-03 8.018027e-03 5 175522375 175522422 48 + 2.604 2.597 -0.021
ENSG00000164466 E036 10.1328145 0.0153222924 1.767891e-03 6.497251e-03 5 175522423 175522842 420 + 1.108 0.718 -1.486
ENSG00000164466 E037 22.6448604 0.0123904134 1.238435e-04 6.314228e-04 5 175522843 175524103 1261 + 1.430 1.080 -1.230
ENSG00000164466 E038 4.8955214 0.0078712342 6.392772e-01 7.526982e-01 5 175525792 175525891 100 + 0.749 0.719 -0.123
ENSG00000164466 E039 3.2303896 0.0797311032 5.974822e-01 7.192316e-01 5 175525892 175525965 74 + 0.557 0.675 0.521
ENSG00000164466 E040 675.6022979 0.0001192683 3.074023e-02 7.340277e-02 5 175526638 175526793 156 + 2.797 2.816 0.063
ENSG00000164466 E041 2093.9656591 0.0017793953 9.083445e-07 7.610257e-06 5 175526794 175528114 1321 + 3.245 3.376 0.435
ENSG00000164466 E042 1271.0433450 0.0098037840 5.754392e-04 2.442283e-03 5 175528115 175529742 1628 + 2.997 3.203 0.685
ENSG00000164466 E043 0.4502799 0.0348485293 3.389489e-01 4.828578e-01 5 175533681 175533728 48 + 0.205 0.000 -10.872
ENSG00000164466 E044 0.0000000       5 175538339 175538395 57 +