ENSG00000164465

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296955 ENSG00000164465 HEK293_OSMI2_2hA HEK293_TMG_2hB DCBLD1 protein_coding protein_coding 7.561041 4.361276 9.408086 0.5695686 0.1471454 1.107379 0.3501816 0.03630796 0.8706956 0.01861251 0.1023789 4.24931130 0.03762083 0.008633333 0.09226667 0.08363333 1.176268e-05 1.176268e-05 FALSE  
ENST00000338728 ENSG00000164465 HEK293_OSMI2_2hA HEK293_TMG_2hB DCBLD1 protein_coding protein_coding 7.561041 4.361276 9.408086 0.5695686 0.1471454 1.107379 4.5817329 2.12278244 6.5065696 0.17654884 0.2681864 1.61137590 0.59470833 0.504666667 0.69283333 0.18816667 1.901322e-01 1.176268e-05 FALSE  
ENST00000478345 ENSG00000164465 HEK293_OSMI2_2hA HEK293_TMG_2hB DCBLD1 protein_coding processed_transcript 7.561041 4.361276 9.408086 0.5695686 0.1471454 1.107379 0.1698588 0.63786292 0.0000000 0.34673528 0.0000000 -6.01761669 0.04139583 0.165633333 0.00000000 -0.16563333 1.365522e-01 1.176268e-05 FALSE  
ENST00000487076 ENSG00000164465 HEK293_OSMI2_2hA HEK293_TMG_2hB DCBLD1 protein_coding processed_transcript 7.561041 4.361276 9.408086 0.5695686 0.1471454 1.107379 0.4246495 0.15078911 0.5539520 0.10002076 0.2426241 1.81040281 0.05813750 0.034900000 0.05850000 0.02360000 7.620475e-01 1.176268e-05    
MSTRG.28871.8 ENSG00000164465 HEK293_OSMI2_2hA HEK293_TMG_2hB DCBLD1 protein_coding   7.561041 4.361276 9.408086 0.5695686 0.1471454 1.107379 1.1761774 0.68053790 0.6580894 0.35612731 0.1620460 -0.04767946 0.13268333 0.151466667 0.06950000 -0.08196667 8.833512e-01 1.176268e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164465 E001 0.0000000       6 117453817 117453833 17 +      
ENSG00000164465 E002 0.0000000       6 117453834 117453897 64 +      
ENSG00000164465 E003 0.0000000       6 117464056 117464165 110 +      
ENSG00000164465 E004 0.0000000       6 117480346 117480470 125 +      
ENSG00000164465 E005 0.0000000       6 117480862 117480999 138 +      
ENSG00000164465 E006 0.6653823 0.0170586769 8.265898e-01 8.908931e-01 6 117482640 117482656 17 + 0.218 0.172 -0.424
ENSG00000164465 E007 1.1135859 0.0121008564 3.242702e-01 4.676310e-01 6 117482657 117482673 17 + 0.363 0.172 -1.425
ENSG00000164465 E008 13.4901467 0.0013063343 1.637615e-05 1.036002e-04 6 117482674 117482893 220 + 1.260 0.768 -1.823
ENSG00000164465 E009 0.7490443 0.0655804080 1.302661e-01 2.345332e-01 6 117484950 117484994 45 + 0.320 0.000 -13.039
ENSG00000164465 E010 1.0435424 0.1552734306 8.060518e-02 1.604962e-01 6 117484995 117485040 46 + 0.403 0.000 -13.153
ENSG00000164465 E011 0.0000000       6 117485041 117485042 2 +      
ENSG00000164465 E012 0.0000000       6 117494756 117494866 111 +      
ENSG00000164465 E013 0.1472490 0.0429820156 1.000000e+00   6 117503559 117503766 208 + 0.086 0.000 -10.943
ENSG00000164465 E014 11.7315870 0.0099680030 3.888708e-03 1.283233e-02 6 117503767 117503783 17 + 1.187 0.834 -1.304
ENSG00000164465 E015 44.0085301 0.0004974287 5.841975e-04 2.475441e-03 6 117503784 117503979 196 + 1.699 1.493 -0.701
ENSG00000164465 E016 0.1451727 0.0431950556 1.000000e+00   6 117508015 117508115 101 + 0.086 0.000 -10.941
ENSG00000164465 E017 46.4100476 0.0103522332 2.346620e-02 5.871515e-02 6 117519816 117519950 135 + 1.710 1.528 -0.619
ENSG00000164465 E018 33.0463093 0.0093624248 5.803674e-01 7.051207e-01 6 117521525 117521576 52 + 1.530 1.474 -0.192
ENSG00000164465 E019 33.8026884 0.0113598792 6.884849e-01 7.905987e-01 6 117525362 117525434 73 + 1.535 1.489 -0.159
ENSG00000164465 E020 42.0942636 0.0057912833 8.115467e-01 8.803998e-01 6 117532260 117532393 134 + 1.625 1.600 -0.083
ENSG00000164465 E021 27.4743370 0.0030015479 2.652789e-01 4.033184e-01 6 117537185 117537225 41 + 1.467 1.377 -0.309
ENSG00000164465 E022 51.6443235 0.0004427227 4.000583e-01 5.437749e-01 6 117538620 117538774 155 + 1.723 1.674 -0.167
ENSG00000164465 E023 44.6221335 0.0004970278 5.908144e-02 1.250481e-01 6 117538775 117538835 61 + 1.680 1.568 -0.380
ENSG00000164465 E024 0.3030308 0.3205294574 6.448459e-01   6 117538836 117539254 419 + 0.158 0.000 -11.107
ENSG00000164465 E025 38.5622533 0.0097889232 9.803665e-02 1.875278e-01 6 117539255 117539308 54 + 1.623 1.490 -0.454
ENSG00000164465 E026 39.3660256 0.0208004967 1.007054e-01 1.915380e-01 6 117539309 117539379 71 + 1.637 1.492 -0.494
ENSG00000164465 E027 1.4949656 0.4464921712 7.862070e-01 8.630905e-01 6 117539380 117540667 1288 + 0.404 0.306 -0.585
ENSG00000164465 E028 54.9767190 0.0024540003 3.881932e-02 8.884786e-02 6 117540668 117540815 148 + 1.770 1.650 -0.408
ENSG00000164465 E029 48.7474404 0.0004627076 3.517252e-01 4.959545e-01 6 117540918 117541025 108 + 1.697 1.641 -0.189
ENSG00000164465 E030 41.0023485 0.0005607267 7.338406e-01 8.249943e-01 6 117543124 117543211 88 + 1.611 1.585 -0.090
ENSG00000164465 E031 2.9151407 0.0351413001 8.362557e-01 8.976137e-01 6 117544270 117544527 258 + 0.583 0.537 -0.211
ENSG00000164465 E032 27.5325372 0.0007377250 5.610968e-01 6.889769e-01 6 117544528 117544531 4 + 1.451 1.403 -0.163
ENSG00000164465 E033 37.3740392 0.0018959493 5.075949e-01 6.430456e-01 6 117544532 117544577 46 + 1.552 1.585 0.113
ENSG00000164465 E034 41.0929972 0.0005617247 6.785703e-02 1.398137e-01 6 117545478 117545597 120 + 1.570 1.665 0.323
ENSG00000164465 E035 289.7557941 0.0002418280 4.032592e-23 3.624110e-21 6 117547907 117549797 1891 + 2.378 2.553 0.582
ENSG00000164465 E036 2.2487287 0.0066422791 1.211286e-01 2.215497e-01 6 117569620 117569858 239 + 0.583 0.295 -1.542