ENSG00000164402

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296873 ENSG00000164402 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN8 protein_coding protein_coding 39.21116 39.13691 42.43792 3.438496 0.6818723 0.1167956 14.579225 12.38823 21.383394 1.735062 4.0990790 0.7870312 0.3689958 0.3263000 0.50120000 0.17490000 3.809725e-01 5.646861e-46 FALSE  
ENST00000448933 ENSG00000164402 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN8 protein_coding protein_coding 39.21116 39.13691 42.43792 3.438496 0.6818723 0.1167956 17.844401 23.34005 11.608783 4.824408 4.1124294 -1.0069665 0.4591333 0.5845667 0.27670000 -0.30786667 1.622351e-01 5.646861e-46 FALSE  
MSTRG.26911.8 ENSG00000164402 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN8 protein_coding   39.21116 39.13691 42.43792 3.438496 0.6818723 0.1167956 2.200138 0.00000 3.766657 0.000000 0.1001971 8.5609661 0.0551500 0.0000000 0.08876667 0.08876667 5.646861e-46 5.646861e-46 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164402 E001 7.7089284 0.0218077901 4.748175e-01 6.136159e-01 5 132750819 132751458 640 - 0.974 0.940 -0.129
ENSG00000164402 E002 9.5407568 0.0174021390 9.941342e-01 1.000000e+00 5 132751459 132752178 720 - 1.002 1.047 0.167
ENSG00000164402 E003 1.8767977 0.0640655907 1.117899e-01 2.081851e-01 5 132752179 132752181 3 - 0.580 0.305 -1.460
ENSG00000164402 E004 0.2924217 0.0290785164 1.960513e-01   5 132754179 132754520 342 - 0.211 0.000 -10.671
ENSG00000164402 E005 1.2897882 0.0128695496 3.107899e-02 7.406343e-02 5 132756001 132756004 4 - 0.118 0.528 2.925
ENSG00000164402 E006 585.4324503 0.0075945604 1.881541e-11 3.745820e-10 5 132756005 132756332 328 - 2.552 2.901 1.160
ENSG00000164402 E007 734.4280770 0.0052710673 1.222322e-09 1.780997e-08 5 132756333 132756642 310 - 2.705 2.975 0.899
ENSG00000164402 E008 1753.9619417 0.0015694880 2.019247e-05 1.250990e-04 5 132756643 132758142 1500 - 3.177 3.299 0.407
ENSG00000164402 E009 96.2377383 0.0005919241 7.694837e-01 8.511197e-01 5 132758143 132758143 1 - 1.960 2.023 0.211
ENSG00000164402 E010 171.0826038 0.0011469538 4.091026e-01 5.527143e-01 5 132758144 132758199 56 - 2.198 2.275 0.257
ENSG00000164402 E011 426.8776272 0.0009439857 1.929864e-02 4.998318e-02 5 132758200 132758556 357 - 2.578 2.678 0.332
ENSG00000164402 E012 433.9957955 0.0019314266 5.938157e-01 7.161238e-01 5 132758557 132758824 268 - 2.623 2.654 0.102
ENSG00000164402 E013 18.5070670 0.0462021601 2.634581e-01 4.013682e-01 5 132758825 132759007 183 - 1.348 1.234 -0.399
ENSG00000164402 E014 375.6377899 0.0001865653 1.355508e-01 2.418825e-01 5 132760802 132760992 191 - 2.566 2.589 0.077
ENSG00000164402 E015 427.6763836 0.0007210754 5.983032e-04 2.527297e-03 5 132761133 132761265 133 - 2.646 2.622 -0.077
ENSG00000164402 E016 298.0886685 0.0001753191 2.009741e-05 1.245875e-04 5 132761458 132761500 43 - 2.498 2.460 -0.125
ENSG00000164402 E017 392.0069296 0.0007679836 2.988050e-05 1.778942e-04 5 132761501 132761626 126 - 2.618 2.576 -0.140
ENSG00000164402 E018 302.5530164 0.0055891861 8.553161e-02 1.682645e-01 5 132761800 132761896 97 - 2.497 2.468 -0.094
ENSG00000164402 E019 371.4028389 0.0029140778 3.081822e-05 1.828391e-04 5 132762484 132762602 119 - 2.615 2.528 -0.290
ENSG00000164402 E020 248.5070111 0.0033400959 9.229947e-06 6.184868e-05 5 132762603 132762645 43 - 2.453 2.340 -0.377
ENSG00000164402 E021 242.7968121 0.0024746583 2.174316e-05 1.336397e-04 5 132763706 132763768 63 - 2.434 2.341 -0.311
ENSG00000164402 E022 232.5666026 0.0002269165 1.961459e-07 1.882625e-06 5 132763769 132763823 55 - 2.407 2.335 -0.240
ENSG00000164402 E023 216.3539051 0.0003854295 1.131068e-07 1.137777e-06 5 132763824 132763886 63 - 2.382 2.300 -0.275
ENSG00000164402 E024 88.9970636 0.0015009363 9.118469e-05 4.805994e-04 5 132763887 132763892 6 - 2.013 1.903 -0.371
ENSG00000164402 E025 6.7507485 0.0473536467 3.159051e-01 4.586806e-01 5 132763961 132764038 78 - 0.945 0.846 -0.376
ENSG00000164402 E026 8.9470433 0.0077923562 8.105907e-01 8.798161e-01 5 132764039 132764064 26 - 0.960 1.034 0.276
ENSG00000164402 E027 7.4957524 0.0504888053 3.071928e-01 4.493888e-01 5 132764065 132764223 159 - 0.989 0.870 -0.452
ENSG00000164402 E028 162.6355112 0.0013602209 1.146093e-05 7.513292e-05 5 132764224 132764258 35 - 2.262 2.168 -0.314
ENSG00000164402 E029 285.8606448 0.0007608614 3.855092e-12 8.588142e-11 5 132764259 132764390 132 - 2.518 2.398 -0.400
ENSG00000164402 E030 156.4451762 0.0025330495 4.246885e-07 3.810370e-06 5 132764391 132764419 29 - 2.266 2.124 -0.475
ENSG00000164402 E031 162.0821788 0.0078869299 5.895892e-05 3.263195e-04 5 132765409 132765529 121 - 2.291 2.125 -0.554
ENSG00000164402 E032 1.3964557 0.0099806463 8.189327e-02 1.625297e-01 5 132773923 132774212 290 - 0.503 0.225 -1.685
ENSG00000164402 E033 0.2214452 0.0453028784 4.935183e-01   5 132775735 132775966 232 - 0.000 0.127 8.792
ENSG00000164402 E034 59.0676722 0.0231439325 1.083479e-02 3.076881e-02 5 132777108 132777421 314 - 1.863 1.679 -0.623
ENSG00000164402 E035 0.4783925 0.0221956758 5.521499e-01 6.814669e-01 5 132777676 132777757 82 - 0.211 0.127 -0.878
ENSG00000164402 E036 0.4720498 0.1587582073 5.994402e-01 7.208184e-01 5 132777758 132777894 137 - 0.210 0.127 -0.873
ENSG00000164402 E037 0.0000000       5 132777895 132778009 115 -      
ENSG00000164402 E038 0.0000000       5 132778085 132778216 132 -      
ENSG00000164402 E039 0.0000000       5 132807066 132807241 176 -