ENSG00000164306

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314970 ENSG00000164306 HEK293_OSMI2_2hA HEK293_TMG_2hB PRIMPOL protein_coding protein_coding 3.910732 2.682636 5.684362 0.2749833 0.2537244 1.080515 1.64640045 0.3327963 3.38720835 0.24967048 0.13941671 3.3089262 0.37131250 0.11080000 0.59923333 0.48843333 2.169958e-02 6.199799e-06 FALSE TRUE
ENST00000503752 ENSG00000164306 HEK293_OSMI2_2hA HEK293_TMG_2hB PRIMPOL protein_coding protein_coding 3.910732 2.682636 5.684362 0.2749833 0.2537244 1.080515 0.33692379 0.1475242 0.41385612 0.14752418 0.24077667 1.4280013 0.07757917 0.05826667 0.06966667 0.01140000 7.677193e-01 6.199799e-06 FALSE TRUE
ENST00000509538 ENSG00000164306 HEK293_OSMI2_2hA HEK293_TMG_2hB PRIMPOL protein_coding retained_intron 3.910732 2.682636 5.684362 0.2749833 0.2537244 1.080515 0.52685461 0.8422320 0.57950956 0.03404798 0.06477283 -0.5317310 0.14657083 0.31866667 0.10153333 -0.21713333 6.199799e-06 6.199799e-06   FALSE
ENST00000510864 ENSG00000164306 HEK293_OSMI2_2hA HEK293_TMG_2hB PRIMPOL protein_coding processed_transcript 3.910732 2.682636 5.684362 0.2749833 0.2537244 1.080515 0.05871513 0.1623645 0.00000000 0.16236448 0.00000000 -4.1073906 0.02292083 0.06413333 0.00000000 -0.06413333 6.779011e-01 6.199799e-06   FALSE
ENST00000512658 ENSG00000164306 HEK293_OSMI2_2hA HEK293_TMG_2hB PRIMPOL protein_coding retained_intron 3.910732 2.682636 5.684362 0.2749833 0.2537244 1.080515 0.74606298 0.7717285 0.56449762 0.31755235 0.14055095 -0.4443668 0.23505833 0.27130000 0.10146667 -0.16983333 1.595145e-01 6.199799e-06   FALSE
ENST00000512834 ENSG00000164306 HEK293_OSMI2_2hA HEK293_TMG_2hB PRIMPOL protein_coding protein_coding 3.910732 2.682636 5.684362 0.2749833 0.2537244 1.080515 0.18531752 0.1884730 0.08939131 0.14877690 0.08939131 -0.9977509 0.04827917 0.07850000 0.01503333 -0.06346667 5.805419e-01 6.199799e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164306 E001 1.333885 0.0115206697 3.856899e-01 0.5298722479 4 184649667 184649694 28 + 0.280 0.440 0.956
ENSG00000164306 E002 2.283270 0.0200791437 6.657470e-01 0.7733811542 4 184649695 184649724 30 + 0.449 0.525 0.375
ENSG00000164306 E003 3.205600 0.0054903222 8.813553e-01 0.9279619265 4 184649725 184649737 13 + 0.570 0.594 0.108
ENSG00000164306 E004 6.948816 0.0034548378 3.500727e-01 0.4942483047 4 184649738 184649755 18 + 0.886 0.754 -0.517
ENSG00000164306 E005 9.399309 0.0018482896 4.588296e-01 0.5990991588 4 184649756 184649776 21 + 0.994 0.904 -0.338
ENSG00000164306 E006 9.171521 0.0019444103 3.216377e-01 0.4648926011 4 184649777 184649780 4 + 0.994 0.871 -0.464
ENSG00000164306 E007 28.654003 0.0009421377 9.906471e-01 0.9983144451 4 184649781 184649908 128 + 1.427 1.427 0.001
ENSG00000164306 E008 30.111016 0.0008021709 8.110001e-01 0.8801394481 4 184652023 184652100 78 + 1.447 1.463 0.057
ENSG00000164306 E009 10.769450 0.0018553887 7.432234e-01 0.8319310524 4 184657082 184657084 3 + 1.025 1.061 0.132
ENSG00000164306 E010 36.200470 0.0005795020 2.272047e-01 0.3590737236 4 184657085 184657320 236 + 1.505 1.578 0.251
ENSG00000164306 E011 5.220026 0.0041084960 9.716934e-06 0.0000648002 4 184657321 184657654 334 + 0.501 1.083 2.355
ENSG00000164306 E012 16.558797 0.0022185611 9.104994e-01 0.9470783221 4 184659340 184659437 98 + 1.200 1.209 0.034
ENSG00000164306 E013 13.569898 0.0013491339 8.393867e-01 0.8996385645 4 184661774 184661903 130 + 1.124 1.104 -0.074
ENSG00000164306 E014 14.286788 0.0015905060 9.052443e-01 0.9436744804 4 184665917 184666064 148 + 1.136 1.123 -0.045
ENSG00000164306 E015 25.341003 0.0374207571 1.534689e-01 0.2663742944 4 184672173 184672460 288 + 1.412 1.230 -0.634
ENSG00000164306 E016 12.658878 0.0138380170 1.480425e-02 0.0400545593 4 184678232 184678276 45 + 1.153 0.836 -1.175
ENSG00000164306 E017 17.624120 0.0012103468 1.251532e-03 0.0048149736 4 184678277 184678394 118 + 1.293 0.963 -1.188
ENSG00000164306 E018 14.609419 0.0012816354 8.217832e-02 0.1629485699 4 184682248 184682336 89 + 1.195 1.015 -0.649
ENSG00000164306 E019 6.451687 0.0026059052 4.237532e-01 0.5667911014 4 184685409 184685411 3 + 0.865 0.754 -0.439
ENSG00000164306 E020 14.852531 0.0012034522 6.395877e-01 0.7529488215 4 184685412 184685498 87 + 1.169 1.123 -0.164
ENSG00000164306 E021 18.334197 0.0010004032 9.827560e-02 0.1879089289 4 184685576 184685684 109 + 1.277 1.123 -0.545
ENSG00000164306 E022 5.068892 0.0128452210 7.636465e-04 0.0031276734 4 184691368 184691498 131 + 0.570 1.037 1.865
ENSG00000164306 E023 20.385545 0.0011168270 6.931668e-02 0.1422271989 4 184691499 184691581 83 + 1.242 1.387 0.505
ENSG00000164306 E024 18.496163 0.0065321556 1.781893e-01 0.2988784917 4 184691666 184691712 47 + 1.210 1.331 0.425
ENSG00000164306 E025 1.471569 0.0259826373 1.823727e-01 0.3041959348 4 184694293 184694370 78 + 0.280 0.524 1.371
ENSG00000164306 E026 31.813443 0.0131139698 1.951903e-01 0.3202357945 4 184694522 184694963 442 + 1.438 1.553 0.393