ENSG00000164294

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000503787 ENSG00000164294 HEK293_OSMI2_2hA HEK293_TMG_2hB GPX8 protein_coding protein_coding 23.30972 10.58534 30.28649 1.205901 2.348039 1.51572 7.233606 2.085975 9.722639 0.4027048 0.1085049 2.2152098 0.2946458 0.1961000 0.3245333 0.1284333 4.239406e-02 1.914096e-07 FALSE TRUE
ENST00000514317 ENSG00000164294 HEK293_OSMI2_2hA HEK293_TMG_2hB GPX8 protein_coding processed_transcript 23.30972 10.58534 30.28649 1.205901 2.348039 1.51572 6.617869 4.723673 7.405616 0.7474000 0.6373418 0.6476065 0.3073167 0.4421667 0.2442667 -0.1979000 1.914096e-07 1.914096e-07 FALSE TRUE
MSTRG.26188.10 ENSG00000164294 HEK293_OSMI2_2hA HEK293_TMG_2hB GPX8 protein_coding   23.30972 10.58534 30.28649 1.205901 2.348039 1.51572 6.742446 2.435997 9.409557 0.3870248 2.0239313 1.9452365 0.2810833 0.2303333 0.3072333 0.0769000 5.521215e-01 1.914096e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164294 E001 0.7665478 0.0245956155 7.701133e-01 8.515526e-01 5 55160167 55160167 1 + 0.250 0.189 -0.513
ENSG00000164294 E002 0.7665478 0.0245956155 7.701133e-01 8.515526e-01 5 55160168 55160168 1 + 0.250 0.189 -0.513
ENSG00000164294 E003 0.7665478 0.0245956155 7.701133e-01 8.515526e-01 5 55160169 55160169 1 + 0.250 0.189 -0.513
ENSG00000164294 E004 0.7665478 0.0245956155 7.701133e-01 8.515526e-01 5 55160170 55160170 1 + 0.250 0.189 -0.513
ENSG00000164294 E005 1.0600137 0.0216622478 8.927012e-01 9.354372e-01 5 55160171 55160173 3 + 0.295 0.320 0.163
ENSG00000164294 E006 4.7915176 0.0130874633 2.080293e-02 5.317556e-02 5 55160174 55160181 8 + 0.822 0.420 -1.790
ENSG00000164294 E007 45.7948598 0.0006331053 4.820509e-02 1.059964e-01 5 55160182 55160194 13 + 1.671 1.554 -0.398
ENSG00000164294 E008 87.5217552 0.0046275320 6.393562e-01 7.527515e-01 5 55160195 55160243 49 + 1.923 1.899 -0.082
ENSG00000164294 E009 89.4019138 0.0045959723 6.078082e-02 1.279416e-01 5 55160244 55160329 86 + 1.952 1.858 -0.315
ENSG00000164294 E010 72.2252882 0.0003428629 4.621801e-01 6.020466e-01 5 55160330 55160346 17 + 1.842 1.807 -0.116
ENSG00000164294 E011 93.0235615 0.0003232614 6.960608e-01 7.965125e-01 5 55160347 55160396 50 + 1.945 1.929 -0.056
ENSG00000164294 E012 0.4482035 0.0274180544 4.169312e-01 5.603221e-01 5 55160397 55160706 310 + 0.200 0.001 -8.745
ENSG00000164294 E013 97.5301832 0.0003352439 5.786991e-01 7.037353e-01 5 55160994 55161051 58 + 1.968 1.945 -0.076
ENSG00000164294 E014 112.8113501 0.0002717251 4.074452e-01 5.510095e-01 5 55161052 55161119 68 + 2.033 2.003 -0.103
ENSG00000164294 E015 148.4843169 0.0004420061 8.228752e-01 8.883249e-01 5 55161120 55161255 136 + 2.138 2.144 0.018
ENSG00000164294 E016 137.5734750 0.0002386645 1.922681e-02 4.982712e-02 5 55164055 55164179 125 + 2.085 2.157 0.242
ENSG00000164294 E017 254.8209711 0.0002611220 4.082228e-10 6.501059e-09 5 55164180 55164599 420 + 2.329 2.467 0.460
ENSG00000164294 E018 403.0813664 0.0002298547 1.369800e-03 5.208319e-03 5 55164600 55167297 2698 + 2.588 2.529 -0.199