ENSG00000164292

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379982 ENSG00000164292 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOBTB3 protein_coding protein_coding 7.525973 3.53896 13.37695 0.2508202 0.4817163 1.915359 5.1302118 1.33493639 9.2390828 0.13261828 0.32046717 2.781772 0.60986250 0.3786000 0.69113333 0.31253333 4.300194e-07 4.300194e-07 FALSE TRUE
ENST00000503737 ENSG00000164292 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOBTB3 protein_coding protein_coding 7.525973 3.53896 13.37695 0.2508202 0.4817163 1.915359 0.6547553 1.65327784 0.2067103 0.33716143 0.20671032 -2.940189 0.19439583 0.4601333 0.01473333 -0.44540000 2.670450e-03 4.300194e-07 FALSE FALSE
MSTRG.26619.5 ENSG00000164292 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOBTB3 protein_coding   7.525973 3.53896 13.37695 0.2508202 0.4817163 1.915359 0.5168700 0.08625219 1.3415110 0.08625219 0.08855172 3.811610 0.04703333 0.0281000 0.10056667 0.07246667 1.889956e-01 4.300194e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164292 E001 0.1515154 0.0430928075 1.000000e+00   5 95713522 95713590 69 + 0.054 0.000 -8.123
ENSG00000164292 E002 0.0000000       5 95713591 95713711 121 +      
ENSG00000164292 E003 0.0000000       5 95717535 95717632 98 +      
ENSG00000164292 E004 0.0000000       5 95717633 95717765 133 +      
ENSG00000164292 E005 0.0000000       5 95730872 95730896 25 +      
ENSG00000164292 E006 11.2340653 0.0019411097 8.691054e-01 9.198773e-01 5 95731146 95731335 190 + 0.946 1.056 0.405
ENSG00000164292 E007 8.4983120 0.0020084848 8.511753e-01 9.077188e-01 5 95731336 95731343 8 + 0.852 0.913 0.234
ENSG00000164292 E008 29.7368430 0.0008256605 7.819986e-01 8.600164e-01 5 95731344 95731684 341 + 1.350 1.424 0.256
ENSG00000164292 E009 1.0371996 0.0195925265 2.195671e-01 3.498724e-01 5 95731725 95731858 134 + 0.285 0.000 -12.224
ENSG00000164292 E010 32.1052785 0.0184283490 1.855504e-01 3.081937e-01 5 95731859 95731955 97 + 1.401 1.356 -0.157
ENSG00000164292 E011 39.1905242 0.0096810401 5.143247e-02 1.117003e-01 5 95731956 95732055 100 + 1.492 1.412 -0.275
ENSG00000164292 E012 28.1616653 0.0063276914 3.631693e-01 5.076016e-01 5 95732056 95732084 29 + 1.342 1.353 0.038
ENSG00000164292 E013 4.5339709 0.0093683340 7.841718e-03 2.338506e-02 5 95732085 95732751 667 + 0.513 0.990 1.960
ENSG00000164292 E014 32.3965203 0.0006786369 2.039157e-02 5.230897e-02 5 95736889 95736938 50 + 1.419 1.321 -0.339
ENSG00000164292 E015 48.8675524 0.0006280668 4.714945e-03 1.513748e-02 5 95736939 95737075 137 + 1.592 1.496 -0.331
ENSG00000164292 E016 22.7419087 0.0028449143 1.078339e-01 2.023335e-01 5 95748333 95748335 3 + 1.271 1.208 -0.223
ENSG00000164292 E017 62.9305039 0.0008493858 1.673312e-02 4.435049e-02 5 95748336 95748487 152 + 1.690 1.644 -0.154
ENSG00000164292 E018 55.4381164 0.0032884216 2.437200e-02 6.058604e-02 5 95752239 95752350 112 + 1.635 1.577 -0.200
ENSG00000164292 E019 98.1277375 0.0005528689 4.072582e-03 1.334680e-02 5 95755396 95755761 366 + 1.876 1.838 -0.130
ENSG00000164292 E020 1.6606605 0.0085505084 2.869749e-03 9.882131e-03 5 95755762 95756093 332 + 0.185 0.762 3.172
ENSG00000164292 E021 57.5004897 0.0004274172 5.708308e-03 1.783936e-02 5 95763508 95763620 113 + 1.653 1.576 -0.260
ENSG00000164292 E022 0.2214452 0.0385820088 8.349145e-02   5 95767755 95767890 136 + 0.000 0.255 13.206
ENSG00000164292 E023 40.9718903 0.0101293240 4.356176e-01 5.778314e-01 5 95768046 95768139 94 + 1.490 1.521 0.106
ENSG00000164292 E024 25.7127447 0.0008720625 3.051879e-01 4.472261e-01 5 95768140 95768166 27 + 1.301 1.304 0.013
ENSG00000164292 E025 0.2903454 0.3343588899 1.000000e+00   5 95780007 95780251 245 + 0.102 0.000 -10.360
ENSG00000164292 E026 31.1120780 0.0007011766 6.890450e-01 7.910213e-01 5 95780252 95780320 69 + 1.357 1.485 0.439
ENSG00000164292 E027 37.8702336 0.0005358075 9.146232e-01 9.499677e-01 5 95780321 95780425 105 + 1.448 1.538 0.307
ENSG00000164292 E028 0.0000000       5 95783582 95783796 215 +      
ENSG00000164292 E029 27.0152870 0.0007819606 4.474511e-02 9.974029e-02 5 95783797 95783833 37 + 1.337 1.249 -0.306
ENSG00000164292 E030 47.6947510 0.0005032053 1.741808e-02 4.586307e-02 5 95783834 95783963 130 + 1.573 1.507 -0.225
ENSG00000164292 E031 35.9936722 0.0006015908 1.863050e-02 4.852070e-02 5 95788762 95788814 53 + 1.459 1.368 -0.313
ENSG00000164292 E032 23.7771359 0.0009010337 1.198815e-02 3.350477e-02 5 95788815 95788820 6 + 1.295 1.139 -0.553
ENSG00000164292 E033 31.4733595 0.0007238720 2.058482e-02 5.271828e-02 5 95788821 95788858 38 + 1.405 1.304 -0.352
ENSG00000164292 E034 2.9601060 0.0135297969 3.406973e-01 4.846404e-01 5 95788859 95789383 525 + 0.456 0.698 1.101
ENSG00000164292 E035 0.1451727 0.0431969626 1.000000e+00   5 95793039 95793058 20 + 0.054 0.000 -9.531
ENSG00000164292 E036 37.3913122 0.0056004430 3.079333e-03 1.049888e-02 5 95793059 95793170 112 + 1.487 1.320 -0.577
ENSG00000164292 E037 124.6190027 0.0003014419 2.108733e-02 5.378062e-02 5 95793171 95794018 848 + 1.973 1.978 0.018
ENSG00000164292 E038 393.2072871 0.0163480575 2.143280e-07 2.042547e-06 5 95794019 95796361 2343 + 2.390 2.733 1.145
ENSG00000164292 E039 0.4428904 0.4189947586 3.901081e-02 8.921715e-02 5 95823837 95824383 547 + 0.000 0.427 13.069