ENSG00000164244

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296666 ENSG00000164244 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC1 protein_coding protein_coding 19.71715 13.06661 31.63912 3.254749 0.6060197 1.275177 14.059077 7.773422 24.032462 2.043226 1.0789811 1.6271080 0.6745542 0.5918333 0.7588333 0.1670000 0.0005642311 0.0005642311 FALSE TRUE
ENST00000512635 ENSG00000164244 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC1 protein_coding protein_coding 19.71715 13.06661 31.63912 3.254749 0.6060197 1.275177 5.289037 5.174415 6.978168 1.259516 0.4902389 0.4307332 0.3043542 0.3975000 0.2213333 -0.1761667 0.0006836801 0.0005642311 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164244 E001 8.704989 0.0021865820 1.233139e-06 1.004405e-05 5 127517640 127517650 11 + 1.083 0.415 -2.795
ENSG00000164244 E002 11.995094 0.0016978452 4.176671e-05 2.396589e-04 5 127517651 127517655 5 + 1.184 0.763 -1.573
ENSG00000164244 E003 121.652451 0.0072672259 1.953163e-06 1.522719e-05 5 127517656 127517776 121 + 2.113 1.896 -0.728
ENSG00000164244 E004 2.803507 0.0055680315 4.446812e-01 5.862458e-01 5 127517946 127517999 54 + 0.577 0.496 -0.379
ENSG00000164244 E005 144.990751 0.0048735963 1.297543e-05 8.392760e-05 5 127523460 127523582 123 + 2.175 2.021 -0.513
ENSG00000164244 E006 1.251283 0.0133128520 7.438235e-01 8.323497e-01 5 127523583 127524108 526 + 0.341 0.316 -0.155
ENSG00000164244 E007 306.265002 0.0099813205 8.506497e-04 3.440207e-03 5 127524531 127524920 390 + 2.490 2.363 -0.422
ENSG00000164244 E008 186.836949 0.0022698708 5.776762e-04 2.451097e-03 5 127526618 127526778 161 + 2.261 2.198 -0.213
ENSG00000164244 E009 130.282638 0.0025059429 3.451716e-01 4.892502e-01 5 127530294 127530396 103 + 2.081 2.105 0.079
ENSG00000164244 E010 173.369929 0.0006004242 4.752283e-02 1.047732e-01 5 127533623 127533786 164 + 2.210 2.218 0.026
ENSG00000164244 E011 174.723927 0.0002800066 2.752394e-01 4.145133e-01 5 127539040 127539143 104 + 2.204 2.243 0.129
ENSG00000164244 E012 86.532540 0.0092385949 3.545678e-01 4.988808e-01 5 127547819 127547834 16 + 1.875 1.986 0.373
ENSG00000164244 E013 162.996018 0.0048877176 3.648979e-01 5.092362e-01 5 127547835 127547921 87 + 2.153 2.245 0.307
ENSG00000164244 E014 21.446599 0.0325350273 1.149417e-03 4.469306e-03 5 127547922 127551706 3785 + 1.406 1.042 -1.288
ENSG00000164244 E015 227.958950 0.0066394680 9.565526e-01 9.767426e-01 5 127551707 127551878 172 + 2.312 2.361 0.165
ENSG00000164244 E016 777.998261 0.0012493628 3.689374e-02 8.526371e-02 5 127551879 127553796 1918 + 2.853 2.884 0.102
ENSG00000164244 E017 813.968787 0.0180059806 1.911725e-04 9.261729e-04 5 127553797 127555085 1289 + 2.775 3.046 0.904