ENSG00000164237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296658 ENSG00000164237 HEK293_OSMI2_2hA HEK293_TMG_2hB CMBL protein_coding protein_coding 13.51645 9.809369 20.19824 0.8888309 0.3589973 1.041241 3.8018391 4.014956 4.580467 0.4266382 0.3502302 0.1896678 0.30468750 0.4124000 0.2274000 -0.18500000 0.008366176 0.008366176 FALSE TRUE
ENST00000506821 ENSG00000164237 HEK293_OSMI2_2hA HEK293_TMG_2hB CMBL protein_coding retained_intron 13.51645 9.809369 20.19824 0.8888309 0.3589973 1.041241 3.5608303 1.642404 5.107458 0.4953958 0.7063882 1.6308609 0.25354167 0.1650000 0.2537333 0.08873333 0.431003581 0.008366176 FALSE TRUE
ENST00000514202 ENSG00000164237 HEK293_OSMI2_2hA HEK293_TMG_2hB CMBL protein_coding retained_intron 13.51645 9.809369 20.19824 0.8888309 0.3589973 1.041241 0.2634575 0.000000 1.347361 0.0000000 0.6804235 7.0846605 0.02180417 0.0000000 0.0658000 0.06580000 0.265156004 0.008366176   FALSE
MSTRG.25934.3 ENSG00000164237 HEK293_OSMI2_2hA HEK293_TMG_2hB CMBL protein_coding   13.51645 9.809369 20.19824 0.8888309 0.3589973 1.041241 5.3732808 3.492563 8.646773 0.1115828 0.7677208 1.3054182 0.37782917 0.3603333 0.4273667 0.06703333 0.505387401 0.008366176 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164237 E001 3.1290352 0.0049679067 5.130156e-01 0.6478636100 5 10275875 10276224 350 - 0.568 0.692 0.535
ENSG00000164237 E002 291.3004926 0.0060742070 8.922768e-06 0.0000600132 5 10277595 10280318 2724 - 2.377 2.554 0.590
ENSG00000164237 E003 100.6859052 0.0027877649 1.445425e-01 0.2542042323 5 10280319 10280465 147 - 1.967 2.056 0.299
ENSG00000164237 E004 116.9237014 0.0011556512 2.137265e-01 0.3429147204 5 10280466 10280632 167 - 2.080 2.069 -0.038
ENSG00000164237 E005 77.2897390 0.0003591294 4.366222e-01 0.5786692358 5 10282197 10282288 92 - 1.895 1.895 0.001
ENSG00000164237 E006 4.1013345 0.0775204919 5.908641e-01 0.7136818747 5 10286132 10286172 41 - 0.653 0.759 0.435
ENSG00000164237 E007 5.1030822 0.0538367431 2.514960e-01 0.3877499624 5 10286173 10286353 181 - 0.679 0.885 0.820
ENSG00000164237 E008 108.4768910 0.0004495119 4.104441e-03 0.0134364572 5 10286354 10286496 143 - 2.067 2.001 -0.221
ENSG00000164237 E009 107.2258681 0.0004640229 2.624848e-03 0.0091430002 5 10288422 10288529 108 - 2.066 1.995 -0.236
ENSG00000164237 E010 0.3030308 0.3706535433 4.013510e-01   5 10290404 10290547 144 - 0.188 0.000 -9.961
ENSG00000164237 E011 153.6610948 0.0012421919 1.133323e-03 0.0044154393 5 10290548 10290781 234 - 2.218 2.148 -0.236
ENSG00000164237 E012 0.3634088 0.3968064911 2.065211e-01   5 10307197 10307380 184 - 0.000 0.253 10.764
ENSG00000164237 E013 2.3070409 0.0848565524 6.310604e-01 0.7461630994 5 10307515 10307624 110 - 0.461 0.575 0.546
ENSG00000164237 E014 87.0510390 0.0101461442 7.007752e-02 0.1434961329 5 10307625 10307902 278 - 1.979 1.896 -0.277