ENSG00000164221

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379611 ENSG00000164221 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC112 protein_coding protein_coding 5.635369 1.891866 8.092607 0.2772459 0.144256 2.090971 1.068496 1.249514 1.954174 0.2999763 0.4936343 0.6410554 0.3148750 0.6507667 0.2435667 -0.4072000 1.506232e-02 1.525846e-06 FALSE TRUE
ENST00000395557 ENSG00000164221 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC112 protein_coding protein_coding 5.635369 1.891866 8.092607 0.2772459 0.144256 2.090971 1.783486 0.000000 2.318001 0.0000000 0.5984603 7.8629481 0.2221500 0.0000000 0.2846667 0.2846667 1.525846e-06 1.525846e-06 FALSE TRUE
ENST00000506442 ENSG00000164221 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC112 protein_coding protein_coding 5.635369 1.891866 8.092607 0.2772459 0.144256 2.090971 2.528444 0.533553 3.546253 0.1836876 0.1446328 2.7098652 0.4192292 0.3047667 0.4378333 0.1330667 5.356562e-01 1.525846e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164221 E001 2.6741131 0.0740929405 2.013476e-01 3.278613e-01 5 115267190 115267354 165 - 0.428 0.684 1.192
ENSG00000164221 E002 2.1580681 0.1434944585 4.379483e-02 9.801646e-02 5 115267355 115267374 20 - 0.303 0.734 2.131
ENSG00000164221 E003 14.8041209 0.0021611116 7.092155e-15 2.390725e-13 5 115267375 115267638 264 - 0.847 1.538 2.473
ENSG00000164221 E004 56.2418940 0.0004268623 9.825160e-08 9.990591e-07 5 115267639 115267918 280 - 1.611 1.871 0.879
ENSG00000164221 E005 46.3691099 0.0021229647 9.159827e-03 2.668217e-02 5 115268882 115269000 119 - 1.562 1.718 0.530
ENSG00000164221 E006 0.5202097 0.0204219819 6.066270e-01 7.267164e-01 5 115269599 115269702 104 - 0.126 0.213 0.917
ENSG00000164221 E007 27.5114708 0.0007780785 2.515751e-01 3.878337e-01 5 115269703 115269798 96 - 1.361 1.450 0.309
ENSG00000164221 E008 84.3476586 0.0003611318 5.991101e-01 7.205775e-01 5 115271213 115271626 414 - 1.866 1.849 -0.058
ENSG00000164221 E009 42.6345642 0.0006106822 3.457887e-01 4.899233e-01 5 115275216 115275334 119 - 1.584 1.530 -0.185
ENSG00000164221 E010 20.7166045 0.0009812645 3.448815e-03 1.157846e-02 5 115275335 115275338 4 - 1.328 1.046 -1.004
ENSG00000164221 E011 59.7994587 0.0005614030 3.673444e-05 2.136306e-04 5 115275339 115275606 268 - 1.766 1.538 -0.775
ENSG00000164221 E012 29.7528064 0.0009685116 3.513911e-02 8.190910e-02 5 115275994 115276069 76 - 1.460 1.300 -0.553
ENSG00000164221 E013 31.1738242 0.0007144416 1.524261e-02 4.103549e-02 5 115276965 115277054 90 - 1.482 1.300 -0.629
ENSG00000164221 E014 0.0000000       5 115277055 115277185 131 -      
ENSG00000164221 E015 32.6005655 0.0007287077 1.700184e-01 2.882150e-01 5 115279647 115279768 122 - 1.482 1.387 -0.326
ENSG00000164221 E016 0.0000000       5 115280352 115280480 129 -      
ENSG00000164221 E017 26.1107615 0.0008693743 4.970172e-02 1.086289e-01 5 115284787 115284908 122 - 1.400 1.241 -0.554
ENSG00000164221 E018 0.1472490 0.0431959290 1.000000e+00   5 115295910 115296268 359 - 0.067 0.001 -6.195
ENSG00000164221 E019 17.1855409 0.0050168145 1.052158e-02 3.002745e-02 5 115296427 115296693 267 - 1.245 0.965 -1.011