ENSG00000164219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379615 ENSG00000164219 HEK293_OSMI2_2hA HEK293_TMG_2hB PGGT1B protein_coding protein_coding 8.636239 2.651623 15.03648 0.5170808 0.1920751 2.499047 1.249498 0.3820594 1.828284 0.38205937 0.4068894 2.229216 0.1102833 0.1038333 0.12230000 0.01846667 0.536662471 0.006025428 FALSE TRUE
ENST00000419445 ENSG00000164219 HEK293_OSMI2_2hA HEK293_TMG_2hB PGGT1B protein_coding protein_coding 8.636239 2.651623 15.03648 0.5170808 0.1920751 2.499047 1.570162 0.4466251 2.794133 0.05200085 0.1066472 2.618473 0.2015167 0.1733667 0.18573333 0.01236667 0.800061832 0.006025428 FALSE TRUE
MSTRG.26767.2 ENSG00000164219 HEK293_OSMI2_2hA HEK293_TMG_2hB PGGT1B protein_coding   8.636239 2.651623 15.03648 0.5170808 0.1920751 2.499047 0.855544 0.5444782 1.421399 0.07570226 0.1131944 1.368223 0.1130458 0.2129667 0.09436667 -0.11860000 0.006025428 0.006025428 FALSE TRUE
MSTRG.26767.3 ENSG00000164219 HEK293_OSMI2_2hA HEK293_TMG_2hB PGGT1B protein_coding   8.636239 2.651623 15.03648 0.5170808 0.1920751 2.499047 4.948779 1.2784607 8.992660 0.11212832 0.3828646 2.804703 0.5743917 0.5098000 0.59763333 0.08783333 0.622013810 0.006025428 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164219 E001 160.733549 0.0002706877 0.0000639054 0.0003505628 5 115204012 115208696 4685 - 2.155 2.018 -0.456
ENSG00000164219 E002 248.244756 0.0002683457 0.0002721942 0.0012665796 5 115208697 115212307 3611 - 2.297 2.382 0.285
ENSG00000164219 E003 27.359991 0.0007131070 0.1795661265 0.3005970184 5 115212308 115212383 76 - 1.355 1.458 0.355
ENSG00000164219 E004 13.755218 0.0012715669 0.5958564456 0.7178782847 5 115212384 115212401 18 - 1.084 1.141 0.204
ENSG00000164219 E005 21.550185 0.0008517022 0.0026033369 0.0090749142 5 115212402 115212419 18 - 1.214 1.458 0.849
ENSG00000164219 E006 57.927837 0.0004365934 0.3121295870 0.4546518058 5 115212420 115212583 164 - 1.680 1.735 0.186
ENSG00000164219 E007 50.412949 0.0004495417 0.3378838898 0.4817609018 5 115216865 115216973 109 - 1.646 1.589 -0.195
ENSG00000164219 E008 69.863696 0.0003790238 0.0201583292 0.0518158936 5 115221824 115222008 185 - 1.795 1.671 -0.417
ENSG00000164219 E009 40.461083 0.0005911028 0.2098849106 0.3384110450 5 115230976 115231021 46 - 1.554 1.468 -0.295
ENSG00000164219 E010 0.000000       5 115231572 115231784 213 -      
ENSG00000164219 E011 56.590304 0.0004001845 0.8486684317 0.9060450176 5 115236390 115236522 133 - 1.679 1.690 0.037
ENSG00000164219 E012 70.315379 0.0008934179 0.3865224803 0.5307030162 5 115237858 115238009 152 - 1.785 1.740 -0.150
ENSG00000164219 E013 45.171444 0.0004862861 0.5205045647 0.6544592408 5 115241539 115241606 68 - 1.597 1.558 -0.136
ENSG00000164219 E014 0.147249 0.0438454126 1.0000000000   5 115252831 115253132 302 - 0.063 0.000 -7.127
ENSG00000164219 E015 3.255853 0.0046190405 0.0478682951 0.1053913594 5 115253133 115253136 4 - 0.633 0.224 -2.286
ENSG00000164219 E016 56.071300 0.0013673403 0.5745151672 0.7003151213 5 115253137 115253255 119 - 1.673 1.707 0.114
ENSG00000164219 E017 43.896859 0.0005236660 0.4681264627 0.6075490778 5 115262712 115262877 166 - 1.565 1.611 0.156