ENSG00000164190

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282516 ENSG00000164190 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPBL protein_coding protein_coding 8.891819 4.547838 11.94832 0.3477254 0.2097545 1.391594 0.4761208 0.0000000 0.6807035 0.0000000 0.680703532 6.109995 0.0370750 0.0000000 0.05576667 0.05576667 9.822330e-01 3.37697e-10 FALSE TRUE
ENST00000448238 ENSG00000164190 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPBL protein_coding protein_coding 8.891819 4.547838 11.94832 0.3477254 0.2097545 1.391594 4.8695039 0.8240113 7.4679375 0.1826797 0.385829401 3.164502 0.4630750 0.1897667 0.62593333 0.43616667 6.856686e-05 3.37697e-10 FALSE TRUE
ENST00000513819 ENSG00000164190 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPBL protein_coding protein_coding 8.891819 4.547838 11.94832 0.3477254 0.2097545 1.391594 0.8657832 1.8569503 0.5884641 0.5120823 0.137384660 -1.641347 0.1262458 0.3970000 0.04933333 -0.34766667 1.183167e-05 3.37697e-10 FALSE FALSE
ENST00000514335 ENSG00000164190 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPBL protein_coding retained_intron 8.891819 4.547838 11.94832 0.3477254 0.2097545 1.391594 0.4134067 0.8408831 0.1524569 0.2168594 0.005261137 -2.388904 0.0929000 0.1804667 0.01276667 -0.16770000 3.376970e-10 3.37697e-10 FALSE TRUE
MSTRG.26082.6 ENSG00000164190 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPBL protein_coding   8.891819 4.547838 11.94832 0.3477254 0.2097545 1.391594 1.8000187 0.9959120 2.2977612 0.1053931 0.366536563 1.197990 0.2436833 0.2250000 0.19213333 -0.03286667 8.493387e-01 3.37697e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164190 E001 0.0000000       5 36876769 36876789 21 +      
ENSG00000164190 E002 0.2924217 0.0273293682 1.000000e+00   5 36876790 36876840 51 + 0.111 0.001 -7.958
ENSG00000164190 E003 2.0628572 0.0142522105 8.200419e-01 8.864482e-01 5 36876841 36876857 17 + 0.416 0.389 -0.147
ENSG00000164190 E004 17.4775298 0.0050203634 8.581376e-05 4.554592e-04 5 36876858 36877130 273 + 1.233 0.728 -1.887
ENSG00000164190 E005 12.2151585 0.0015794584 2.178595e-03 7.775590e-03 5 36877131 36877178 48 + 1.083 0.665 -1.617
ENSG00000164190 E006 31.6388176 0.0006318279 1.180541e-08 1.436324e-07 5 36953618 36953760 143 + 1.483 0.916 -2.020
ENSG00000164190 E007 0.0000000       5 36954968 36955010 43 +      
ENSG00000164190 E008 39.2082338 0.0005255050 1.943750e-09 2.728494e-08 5 36955472 36955637 166 + 1.571 1.047 -1.838
ENSG00000164190 E009 30.2319587 0.0115592100 9.391798e-05 4.933585e-04 5 36958104 36958231 128 + 1.454 1.047 -1.437
ENSG00000164190 E010 14.0057400 0.0027692947 1.286165e-02 3.559213e-02 5 36961484 36961505 22 + 1.128 0.832 -1.100
ENSG00000164190 E011 22.6439948 0.0043451077 1.040813e-05 6.891718e-05 5 36961506 36961583 78 + 1.340 0.833 -1.849
ENSG00000164190 E012 36.1580330 0.0005459554 1.012665e-08 1.246889e-07 5 36962123 36962274 152 + 1.536 1.018 -1.824
ENSG00000164190 E013 37.1644203 0.0012449378 3.165212e-07 2.914127e-06 5 36970876 36971036 161 + 1.539 1.100 -1.536
ENSG00000164190 E014 33.2561003 0.0006280686 1.161499e-08 1.415338e-07 5 36971945 36972041 97 + 1.501 0.953 -1.946
ENSG00000164190 E015 101.5036319 0.0003330901 4.396635e-14 1.314598e-12 5 36975776 36976402 627 + 1.963 1.587 -1.271
ENSG00000164190 E016 218.5890068 0.0006554353 3.434189e-24 3.477267e-22 5 36984676 36986301 1626 + 2.291 1.941 -1.172
ENSG00000164190 E017 0.2966881 0.0269547359 1.000000e+00   5 36995150 36995621 472 + 0.111 0.000 -10.398
ENSG00000164190 E018 43.0737332 0.0007022661 1.288193e-07 1.281139e-06 5 36995622 36995749 128 + 1.601 1.190 -1.425
ENSG00000164190 E019 27.6209171 0.0007522507 9.212308e-06 6.174577e-05 5 36995750 36995804 55 + 1.415 0.987 -1.524
ENSG00000164190 E020 0.1817044 0.0391953419 8.854034e-02   5 36996472 36997002 531 + 0.000 0.237 11.613
ENSG00000164190 E021 56.1750378 0.0004405245 6.892913e-08 7.222975e-07 5 37000373 37000570 198 + 1.709 1.357 -1.207
ENSG00000164190 E022 31.6392119 0.0006276890 6.654982e-03 2.032806e-02 5 37000817 37000888 72 + 1.450 1.247 -0.707
ENSG00000164190 E023 31.6605214 0.0006422095 1.468846e-04 7.336560e-04 5 37000989 37001078 90 + 1.463 1.147 -1.106
ENSG00000164190 E024 32.2885288 0.0008068964 1.645103e-05 1.040392e-04 5 37002662 37002765 104 + 1.474 1.100 -1.313
ENSG00000164190 E025 31.7061981 0.0390593219 8.768527e-03 2.570398e-02 5 37003261 37003347 87 + 1.459 1.156 -1.059
ENSG00000164190 E026 68.6872770 0.0003894227 2.056197e-03 7.399381e-03 5 37006357 37006588 232 + 1.767 1.619 -0.502
ENSG00000164190 E027 56.7819286 0.0012833348 6.935508e-04 2.875394e-03 5 37007323 37007474 152 + 1.694 1.498 -0.668
ENSG00000164190 E028 37.1545366 0.0008479298 1.067771e-01 2.007961e-01 5 37008008 37008088 81 + 1.501 1.409 -0.318
ENSG00000164190 E029 39.1109643 0.0005447084 4.316645e-01 5.742039e-01 5 37008623 37008723 101 + 1.513 1.487 -0.089
ENSG00000164190 E030 47.4682483 0.0004918930 7.485787e-02 1.512994e-01 5 37010087 37010225 139 + 1.606 1.517 -0.304
ENSG00000164190 E031 40.3124055 0.0031992449 2.508776e-01 3.869846e-01 5 37014683 37014765 83 + 1.532 1.476 -0.192
ENSG00000164190 E032 44.4081143 0.0185974466 5.253782e-02 1.136799e-01 5 37016038 37016170 133 + 1.589 1.429 -0.549
ENSG00000164190 E033 43.1616534 0.0007783993 3.304980e-04 1.502781e-03 5 37017019 37017162 144 + 1.586 1.343 -0.839
ENSG00000164190 E034 46.8390505 0.0004636131 5.137854e-04 2.210918e-03 5 37019311 37019400 90 + 1.616 1.396 -0.755
ENSG00000164190 E035 70.6482071 0.0003300589 2.522223e-04 1.184530e-03 5 37020459 37020673 215 + 1.785 1.603 -0.616
ENSG00000164190 E036 47.6268179 0.0004924571 2.256072e-01 3.571211e-01 5 37020775 37020877 103 + 1.594 1.545 -0.170
ENSG00000164190 E037 56.9396571 0.0175471467 1.357569e-01 2.421636e-01 5 37022051 37022149 99 + 1.678 1.585 -0.316
ENSG00000164190 E038 62.4760722 0.0004195745 1.292706e-01 2.331699e-01 5 37022244 37022390 147 + 1.713 1.655 -0.195
ENSG00000164190 E039 51.8513122 0.0013732686 4.550318e-01 5.955935e-01 5 37024585 37024719 135 + 1.606 1.682 0.261
ENSG00000164190 E040 45.1594919 0.0009069247 6.591504e-01 7.680446e-01 5 37026229 37026327 99 + 1.552 1.611 0.202
ENSG00000164190 E041 33.7929640 0.0006870365 9.773285e-01 9.898739e-01 5 37027359 37027412 54 + 1.434 1.466 0.111
ENSG00000164190 E042 40.4302635 0.0005179306 3.269179e-01 4.703664e-01 5 37036379 37036487 109 + 1.526 1.487 -0.134
ENSG00000164190 E043 58.1439308 0.0004223854 3.907325e-01 5.346972e-01 5 37038602 37038738 137 + 1.675 1.655 -0.069
ENSG00000164190 E044 58.2386943 0.0006134918 2.366298e-01 3.702773e-01 5 37044347 37044487 141 + 1.652 1.749 0.328
ENSG00000164190 E045 50.0354752 0.0004712296 3.761972e-03 1.247474e-02 5 37044636 37044729 94 + 1.563 1.760 0.669
ENSG00000164190 E046 60.9116172 0.0004489239 2.918272e-03 1.002535e-02 5 37045443 37045597 155 + 1.648 1.835 0.634
ENSG00000164190 E047 32.6063260 0.0006662651 1.600999e-04 7.922485e-04 5 37046109 37046199 91 + 1.352 1.641 0.992
ENSG00000164190 E048 53.8821930 0.0012352243 1.017779e-08 1.252698e-07 5 37048502 37048675 174 + 1.549 1.891 1.161
ENSG00000164190 E049 76.9203159 0.0004071148 2.007102e-04 9.668416e-04 5 37049111 37049301 191 + 1.743 1.948 0.689
ENSG00000164190 E050 1.8424692 0.0076343981 9.161340e-01 9.509786e-01 5 37050943 37051778 836 + 0.391 0.389 -0.013
ENSG00000164190 E051 60.7278100 0.0004590507 5.421203e-03 1.707307e-02 5 37051779 37051886 108 + 1.648 1.826 0.603
ENSG00000164190 E052 84.9355949 0.0003269584 2.436239e-06 1.859916e-05 5 37052366 37052566 201 + 1.777 2.013 0.797
ENSG00000164190 E053 79.0228183 0.0021552192 1.757348e-05 1.103751e-04 5 37057186 37057332 147 + 1.746 1.988 0.816
ENSG00000164190 E054 39.3410029 0.0175728177 8.755922e-04 3.528875e-03 5 37058891 37058902 12 + 1.427 1.746 1.090
ENSG00000164190 E055 112.2777443 0.0008479089 1.684504e-14 5.375361e-13 5 37058903 37059165 263 + 1.867 2.193 1.094
ENSG00000164190 E056 84.1579524 0.0054384739 5.081259e-10 7.941830e-09 5 37060844 37061018 175 + 1.725 2.093 1.240
ENSG00000164190 E057 96.5478716 0.0068174586 6.922187e-16 2.671939e-14 5 37063790 37063978 189 + 1.747 2.214 1.568
ENSG00000164190 E058 19.5239198 0.0013912523 5.493037e-11 1.012492e-09 5 37063979 37064019 41 + 1.033 1.596 1.971
ENSG00000164190 E059 19.9850389 0.0009076270 6.473152e-09 8.271410e-08 5 37064020 37064190 171 + 1.073 1.571 1.743
ENSG00000164190 E060 141.5467466 0.0166784004 1.961028e-10 3.289453e-09 5 37064527 37066413 1887 + 1.916 2.378 1.548