ENSG00000164187

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296603 ENSG00000164187 HEK293_OSMI2_2hA HEK293_TMG_2hB LMBRD2 protein_coding protein_coding 3.199959 0.650075 4.637421 0.2264962 0.01984494 2.815728 2.2887175 0.34248599 3.5722186 0.03625822 0.1522323 3.345216 0.7139458 0.62446667 0.7701 0.1456333 0.485012468 0.005114026 FALSE TRUE
ENST00000503535 ENSG00000164187 HEK293_OSMI2_2hA HEK293_TMG_2hB LMBRD2 protein_coding retained_intron 3.199959 0.650075 4.637421 0.2264962 0.01984494 2.815728 0.1016557 0.27346070 0.0000000 0.19202421 0.0000000 -4.825077 0.1326583 0.30606667 0.0000 -0.3060667 0.005114026 0.005114026   FALSE
MSTRG.26064.2 ENSG00000164187 HEK293_OSMI2_2hA HEK293_TMG_2hB LMBRD2 protein_coding   3.199959 0.650075 4.637421 0.2264962 0.01984494 2.815728 0.6856118 0.03412828 0.9003864 0.00370240 0.1873274 4.366704 0.1272083 0.06946667 0.1945 0.1250333 0.121569793 0.005114026 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164187 E001 235.6722200 0.0025860417 5.092480e-06 3.618160e-05 5 36098407 36103848 5442 - 2.146 2.305 0.534
ENSG00000164187 E002 28.4822143 0.0007647285 3.303407e-01 4.739377e-01 5 36103849 36104106 258 - 1.275 1.192 -0.292
ENSG00000164187 E003 24.1961591 0.0007814597 2.414617e-01 3.758922e-01 5 36105068 36105197 130 - 1.212 1.095 -0.418
ENSG00000164187 E004 1.1072432 0.0116166030 6.663170e-01 7.737855e-01 5 36108522 36108533 12 - 0.207 0.310 0.768
ENSG00000164187 E005 21.5263098 0.0008976130 8.811499e-02 1.722592e-01 5 36108534 36108639 106 - 1.172 0.969 -0.736
ENSG00000164187 E006 15.2141625 0.0011954006 8.980105e-01 9.388974e-01 5 36109945 36109991 47 - 1.012 1.015 0.014
ENSG00000164187 E007 18.7311642 0.0078465858 2.486157e-01 3.842913e-01 5 36111155 36111258 104 - 1.111 0.969 -0.517
ENSG00000164187 E008 11.4967269 0.0077844726 4.849867e-01 6.229146e-01 5 36114424 36114484 61 - 0.893 1.015 0.456
ENSG00000164187 E009 8.9756513 0.0019033315 7.774225e-01 8.567693e-01 5 36114485 36114521 37 - 0.820 0.792 -0.108
ENSG00000164187 E010 15.7914206 0.0010940053 1.566650e-01 2.706595e-01 5 36115015 36115120 106 - 1.049 0.860 -0.708
ENSG00000164187 E011 14.8951153 0.0011834019 3.837442e-02 8.805533e-02 5 36116460 36116593 134 - 1.033 0.713 -1.234
ENSG00000164187 E012 18.0371767 0.0320336233 1.292437e-01 2.331356e-01 5 36117735 36117916 182 - 1.103 0.860 -0.903
ENSG00000164187 E013 20.7451961 0.0016123878 2.248178e-01 3.562108e-01 5 36122280 36122463 184 - 1.150 1.015 -0.489
ENSG00000164187 E014 19.8148287 0.0010295018 1.175508e-02 3.294668e-02 5 36122848 36122961 114 - 1.147 0.792 -1.327
ENSG00000164187 E015 16.7763844 0.0011005543 7.628492e-04 3.124832e-03 5 36124191 36124265 75 - 1.090 0.488 -2.443
ENSG00000164187 E016 28.1481710 0.0007707472 3.816744e-05 2.211090e-04 5 36136309 36136519 211 - 1.298 0.713 -2.180
ENSG00000164187 E017 23.9542724 0.0289497530 8.900183e-03 2.603123e-02 5 36137274 36137441 168 - 1.226 0.793 -1.605
ENSG00000164187 E018 0.9963223 0.0129823500 2.222180e-07 2.111790e-06 5 36141041 36141106 66 - 0.000 0.859 14.146
ENSG00000164187 E019 19.7169952 0.0052511376 1.890097e-01 3.125012e-01 5 36141107 36141202 96 - 1.101 1.270 0.603
ENSG00000164187 E020 18.0244016 0.0011251380 8.247096e-02 1.634109e-01 5 36142502 36142599 98 - 1.057 1.271 0.766
ENSG00000164187 E021 0.0000000       5 36142600 36142757 158 -      
ENSG00000164187 E022 22.9782551 0.0043402227 8.277607e-01 8.917262e-01 5 36143176 36143406 231 - 1.175 1.220 0.162
ENSG00000164187 E023 2.0209488 0.0074318031 2.702083e-05 1.625033e-04 5 36151088 36151555 468 - 0.179 0.918 3.838
ENSG00000164187 E024 22.1187439 0.0009847672 3.413019e-01 4.852148e-01 5 36151556 36151887 332 - 1.147 1.271 0.439