ENSG00000164181

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000425382 ENSG00000164181 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL7 protein_coding protein_coding 5.145696 1.62789 9.028548 0.1234955 0.5853066 2.464253 1.3076501 1.27318231 1.9996701 0.19468482 0.1553197 0.6472326 0.27307500 0.772333333 0.22203333 -0.55030000 5.481006e-11 5.481006e-11 FALSE TRUE
ENST00000508821 ENSG00000164181 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL7 protein_coding protein_coding 5.145696 1.62789 9.028548 0.1234955 0.5853066 2.464253 2.6412925 0.34427178 5.0157846 0.07693332 0.1153827 3.8264204 0.58022917 0.221666667 0.55913333 0.33746667 7.520159e-04 5.481006e-11 FALSE TRUE
MSTRG.26249.1 ENSG00000164181 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL7 protein_coding   5.145696 1.62789 9.028548 0.1234955 0.5853066 2.464253 0.7102369 0.00000000 0.4990877 0.00000000 0.4990877 5.6698423 0.07647917 0.000000000 0.04903333 0.04903333 1.000000e+00 5.481006e-11 TRUE TRUE
MSTRG.26249.5 ENSG00000164181 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL7 protein_coding   5.145696 1.62789 9.028548 0.1234955 0.5853066 2.464253 0.2953239 0.01043549 1.3007364 0.01043549 0.1314190 6.0031569 0.03667917 0.005966667 0.14583333 0.13986667 3.489601e-05 5.481006e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164181 E001 0.0000000       5 60748306 60748331 26 -      
ENSG00000164181 E002 0.1482932 0.0412277968 0.079250312   5 60751791 60751791 1 - 0.000 0.264 14.615
ENSG00000164181 E003 0.2934659 0.0299985811 0.243477057   5 60751792 60751792 1 - 0.052 0.264 2.731
ENSG00000164181 E004 280.9902695 0.0350731204 0.002738076 0.009486991 5 60751793 60754385 2593 - 2.250 2.541 0.971
ENSG00000164181 E005 23.3376850 0.0008698139 0.435926065 0.578074292 5 60754386 60754457 72 - 1.244 1.289 0.160
ENSG00000164181 E006 20.5836116 0.0009256125 0.107163131 0.201353276 5 60754458 60754506 49 - 1.208 1.159 -0.174
ENSG00000164181 E007 65.2660193 0.0007415658 0.136530530 0.243225218 5 60754507 60754833 327 - 1.674 1.711 0.125
ENSG00000164181 E008 42.2955695 0.0005031706 0.035504548 0.082623867 5 60757509 60757645 137 - 1.502 1.470 -0.110
ENSG00000164181 E009 17.4375334 0.0011060849 0.028371963 0.068754024 5 60764227 60764229 3 - 1.150 1.010 -0.507
ENSG00000164181 E010 24.1241740 0.0008691328 0.016827692 0.044548164 5 60764230 60764260 31 - 1.280 1.159 -0.426
ENSG00000164181 E011 33.4842339 0.0007380234 0.071241584 0.145399750 5 60764261 60764332 72 - 1.402 1.374 -0.096
ENSG00000164181 E012 31.3342780 0.0012045875 0.027808565 0.067637042 5 60766574 60766630 57 - 1.380 1.308 -0.250
ENSG00000164181 E013 34.8613124 0.0197250775 0.633512860 0.748208364 5 60767823 60767903 81 - 1.400 1.477 0.266
ENSG00000164181 E014 0.4545463 0.6042232021 1.000000000 1.000000000 5 60768646 60768690 45 - 0.141 0.000 -11.031
ENSG00000164181 E015 25.6391297 0.0007943314 0.138800623 0.246439693 5 60771903 60771948 46 - 1.288 1.270 -0.063
ENSG00000164181 E016 39.5534258 0.0007144416 0.328504788 0.472004357 5 60771949 60772093 145 - 1.457 1.506 0.169
ENSG00000164181 E017 1.3423068 0.2232628317 0.225757666 0.357296557 5 60784094 60784212 119 - 0.330 0.000 -12.608
ENSG00000164181 E018 0.0000000       5 60785824 60786051 228 -      
ENSG00000164181 E019 29.0821633 0.0075804286 0.075403253 0.152166160 5 60787334 60787431 98 - 1.347 1.291 -0.195
ENSG00000164181 E020 0.1817044 0.0405689793 0.078577322   5 60787432 60787465 34 - 0.000 0.265 14.626
ENSG00000164181 E021 15.0019687 0.0013360216 0.001284948 0.004926625 5 60799180 60799230 51 - 1.109 0.781 -1.236
ENSG00000164181 E022 2.2206161 0.0094193411 0.251855945 0.388148305 5 60802627 60802665 39 - 0.442 0.265 -1.075
ENSG00000164181 E023 0.1482932 0.0412277968 0.079250312   5 60843422 60843538 117 - 0.000 0.264 14.622
ENSG00000164181 E024 15.6535302 0.0012552807 0.084839388 0.167150958 5 60844160 60844309 150 - 1.101 1.010 -0.331