ENSG00000164180

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296595 ENSG00000164180 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM161B protein_coding protein_coding 8.549782 1.648229 13.30283 0.1343135 0.5601958 3.005102 4.1138251 1.0836012 5.637811 0.399858444 0.05447582 2.368605 0.51994583 0.63073333 0.42516667 -0.2055667 5.653071e-01 2.094757e-10 FALSE TRUE
ENST00000506536 ENSG00000164180 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM161B protein_coding protein_coding 8.549782 1.648229 13.30283 0.1343135 0.5601958 3.005102 0.5917163 0.3360743 1.062742 0.249715400 0.22205466 1.632150 0.09780000 0.22586667 0.07886667 -0.1470000 9.103589e-01 2.094757e-10 FALSE TRUE
ENST00000510089 ENSG00000164180 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM161B protein_coding nonsense_mediated_decay 8.549782 1.648229 13.30283 0.1343135 0.5601958 3.005102 0.9405931 0.1020107 1.256211 0.007519105 0.03743468 3.498810 0.11258750 0.06283333 0.09453333 0.0317000 4.266729e-01 2.094757e-10 TRUE FALSE
MSTRG.26547.4 ENSG00000164180 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM161B protein_coding   8.549782 1.648229 13.30283 0.1343135 0.5601958 3.005102 1.3527738 0.0000000 2.578364 0.000000000 0.15619680 8.015897 0.09124167 0.00000000 0.19370000 0.1937000 2.094757e-10 2.094757e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164180 E001 4.5320015 0.0043295026 6.586292e-01 7.676781e-01 5 88189439 88189479 41 - 0.636 0.554 -0.362
ENSG00000164180 E002 4.8369949 0.0436692572 6.184319e-01 7.360614e-01 5 88189480 88189533 54 - 0.660 0.555 -0.464
ENSG00000164180 E003 4.7184648 0.0114119825 9.618471e-01 9.799279e-01 5 88189633 88189961 329 - 0.636 0.648 0.051
ENSG00000164180 E004 3.4602459 0.0962390009 6.501449e-01 7.612361e-01 5 88189962 88190050 89 - 0.554 0.436 -0.580
ENSG00000164180 E005 2.2070108 0.0073031408 3.597845e-01 5.041111e-01 5 88190051 88190155 105 - 0.372 0.554 0.934
ENSG00000164180 E006 2.5883799 0.0058480593 3.634237e-01 5.078261e-01 5 88190156 88190230 75 - 0.472 0.270 -1.192
ENSG00000164180 E007 2.6031417 0.0552563701 3.955646e-01 5.393667e-01 5 88190231 88190261 31 - 0.473 0.271 -1.189
ENSG00000164180 E008 1.1802960 0.0108032267 3.185396e-01 4.615048e-01 5 88195047 88195168 122 - 0.298 0.000 -11.104
ENSG00000164180 E009 0.5911862 0.0193874923 9.660177e-01 9.826365e-01 5 88195169 88195206 38 - 0.174 0.000 -10.104
ENSG00000164180 E010 86.6231213 0.0041218687 1.225569e-13 3.439708e-12 5 88195207 88195827 621 - 1.716 2.100 1.290
ENSG00000164180 E011 69.9177308 0.0004131161 1.958529e-11 3.887000e-10 5 88195828 88196116 289 - 1.637 1.973 1.136
ENSG00000164180 E012 68.7394435 0.0003689400 7.375883e-07 6.305397e-06 5 88196117 88196349 233 - 1.649 1.909 0.879
ENSG00000164180 E013 29.2332048 0.0010358714 1.396019e-03 5.293351e-03 5 88196350 88196375 26 - 1.292 1.549 0.890
ENSG00000164180 E014 45.3017217 0.0014288431 3.817666e-01 5.260567e-01 5 88196376 88196488 113 - 1.512 1.580 0.232
ENSG00000164180 E015 28.8249125 0.0018288164 4.056687e-01 5.493283e-01 5 88197669 88197765 97 - 1.321 1.400 0.274
ENSG00000164180 E016 18.7273577 0.0231950538 3.880207e-01 5.321366e-01 5 88197766 88198975 1210 - 1.136 1.240 0.370
ENSG00000164180 E017 43.0948673 0.0007140496 6.641108e-01 7.719870e-01 5 88198976 88199069 94 - 1.492 1.528 0.125
ENSG00000164180 E018 50.1587506 0.0004484772 9.345882e-01 9.628030e-01 5 88199070 88199150 81 - 1.561 1.560 -0.005
ENSG00000164180 E019 65.8412335 0.0004086703 1.138229e-04 5.853419e-04 5 88199151 88202683 3533 - 1.710 1.442 -0.915
ENSG00000164180 E020 8.5779140 0.0020211742 1.472108e-02 3.986198e-02 5 88202684 88202942 259 - 0.897 0.435 -2.000
ENSG00000164180 E021 4.7403259 0.0033441395 6.441310e-03 1.976909e-02 5 88202943 88202961 19 - 0.693 0.000 -13.104
ENSG00000164180 E022 62.9587701 0.0019533429 9.815197e-02 1.877123e-01 5 88202962 88203075 114 - 1.671 1.560 -0.377
ENSG00000164180 E023 1.7683591 0.0092113559 5.993689e-01 7.207790e-01 5 88205754 88205800 47 - 0.324 0.435 0.640
ENSG00000164180 E024 2.0671236 0.0072106731 7.702839e-01 8.516419e-01 5 88205801 88205813 13 - 0.372 0.435 0.349
ENSG00000164180 E025 56.7518928 0.0007084759 2.042853e-01 3.315166e-01 5 88205814 88205954 141 - 1.623 1.539 -0.286
ENSG00000164180 E026 0.0000000       5 88206420 88206438 19 -      
ENSG00000164180 E027 32.8610087 0.0010006240 1.777837e-01 2.983434e-01 5 88206439 88206499 61 - 1.400 1.281 -0.415
ENSG00000164180 E028 21.0330366 0.0009290121 2.271337e-01 3.589765e-01 5 88207029 88207034 6 - 1.217 1.086 -0.469
ENSG00000164180 E029 40.8153329 0.0039014949 2.750756e-01 4.143235e-01 5 88207035 88207142 108 - 1.488 1.400 -0.305
ENSG00000164180 E030 27.2781967 0.0068207391 1.928377e-01 3.173302e-01 5 88207143 88207180 38 - 1.326 1.194 -0.466
ENSG00000164180 E031 32.0329176 0.0046052318 1.010540e-01 1.920719e-01 5 88220563 88220614 52 - 1.396 1.239 -0.547
ENSG00000164180 E032 45.9787060 0.0037799687 2.785411e-01 4.182156e-01 5 88220615 88220719 105 - 1.539 1.455 -0.288
ENSG00000164180 E033 0.7687379 0.1191686019 6.087462e-01 7.283852e-01 5 88221301 88221471 171 - 0.174 0.270 0.811
ENSG00000164180 E034 0.7406253 0.0154072004 6.352444e-01 7.495910e-01 5 88221674 88221760 87 - 0.208 0.000 -10.426
ENSG00000164180 E035 38.2862002 0.0007691821 7.590824e-03 2.274762e-02 5 88225769 88225866 98 - 1.477 1.240 -0.827
ENSG00000164180 E036 0.0000000       5 88228441 88228444 4 -      
ENSG00000164180 E037 25.4994896 0.0007573172 3.936040e-02 8.983880e-02 5 88228445 88228458 14 - 1.305 1.086 -0.777
ENSG00000164180 E038 47.4037634 0.0015747179 1.339946e-03 5.109679e-03 5 88228459 88228528 70 - 1.569 1.300 -0.927
ENSG00000164180 E039 44.5602916 0.0045176907 9.692539e-06 6.465117e-05 5 88240813 88240916 104 - 1.557 1.116 -1.540
ENSG00000164180 E040 0.0000000       5 88250651 88251037 387 -      
ENSG00000164180 E041 0.0000000       5 88259232 88259363 132 -      
ENSG00000164180 E042 39.1501196 0.0006015801 7.487370e-06 5.118207e-05 5 88268721 88268787 67 - 1.503 1.054 -1.579
ENSG00000164180 E043 28.9735177 0.0125681201 1.775379e-03 6.520621e-03 5 88268788 88269070 283 - 1.375 0.982 -1.403
ENSG00000164180 E044 0.0000000       5 88269364 88269476 113 -