ENSG00000164176

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296591 ENSG00000164176 HEK293_OSMI2_2hA HEK293_TMG_2hB EDIL3 protein_coding protein_coding 0.4627593 0.171035 1.091022 0.04475304 0.03711178 2.604503 0.20476565 0.02146024 0.4686149 0.02146024 0.05367410 3.927264 0.31351667 0.08236667 0.4296333 0.3472667 0.17335406 0.04644553 FALSE TRUE
ENST00000380138 ENSG00000164176 HEK293_OSMI2_2hA HEK293_TMG_2hB EDIL3 protein_coding protein_coding 0.4627593 0.171035 1.091022 0.04475304 0.03711178 2.604503 0.20510853 0.14957480 0.5099464 0.02331184 0.04132499 1.704130 0.59541250 0.91763333 0.4690667 -0.4485667 0.04644553 0.04644553 FALSE TRUE
ENST00000510271 ENSG00000164176 HEK293_OSMI2_2hA HEK293_TMG_2hB EDIL3 protein_coding processed_transcript 0.4627593 0.171035 1.091022 0.04475304 0.03711178 2.604503 0.04657119 0.00000000 0.1124611 0.00000000 0.03467457 3.614252 0.06188333 0.00000000 0.1012667 0.1012667 0.42339366 0.04644553 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164176 E001 0.1482932 0.041159753 5.383687e-02   5 83940554 83940599 46 - 0.000 0.258 11.119
ENSG00000164176 E002 35.7480224 0.003615506 5.648635e-07 4.947156e-06 5 83940600 83943568 2969 - 1.386 1.659 0.936
ENSG00000164176 E003 6.6652955 0.002529931 6.139037e-01 7.325062e-01 5 83963205 83963360 156 - 0.784 0.705 -0.320
ENSG00000164176 E004 1.0373134 0.013017185 3.643526e-01 5.087263e-01 5 84047606 84048272 667 - 0.281 0.000 -12.777
ENSG00000164176 E005 8.2417581 0.008031856 8.237980e-01 8.889810e-01 5 84060300 84060484 185 - 0.845 0.875 0.118
ENSG00000164176 E006 6.6373097 0.002997484 3.237918e-01 4.671209e-01 5 84064700 84064844 145 - 0.793 0.629 -0.679
ENSG00000164176 E007 5.0713557 0.003215704 2.770662e-02 6.743498e-02 5 84066451 84066606 156 - 0.724 0.259 -2.401
ENSG00000164176 E008 0.0000000       5 84078629 84078828 200 -      
ENSG00000164176 E009 2.2477983 0.006898734 3.895108e-01 5.335931e-01 5 84106649 84106659 11 - 0.451 0.259 -1.164
ENSG00000164176 E010 6.7312020 0.006318728 1.235086e-01 2.249537e-01 5 84106660 84106830 171 - 0.811 0.537 -1.164
ENSG00000164176 E011 6.0210177 0.004108721 4.522905e-01 5.931528e-01 5 84137241 84137354 114 - 0.755 0.629 -0.527
ENSG00000164176 E012 5.7084099 0.004358155 2.461897e-01 3.814812e-01 5 84180393 84180521 129 - 0.745 0.537 -0.901
ENSG00000164176 E013 0.0000000       5 84181099 84181242 144 -      
ENSG00000164176 E014 1.0457324 0.013921497 3.656851e-01 5.099875e-01 5 84229855 84229884 30 - 0.281 0.000 -12.777
ENSG00000164176 E015 4.2908627 0.004962065 5.681496e-02 1.211415e-01 5 84254084 84254212 129 - 0.667 0.258 -2.164
ENSG00000164176 E016 3.2451303 0.032164890 1.663713e-01 2.834806e-01 5 84384308 84384386 79 - 0.572 0.258 -1.751
ENSG00000164176 E017 3.0936149 0.062116425 2.089997e-01 3.373208e-01 5 84384387 84384880 494 - 0.556 0.258 -1.682