ENSG00000164172

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000510818 ENSG00000164172 HEK293_OSMI2_2hA HEK293_TMG_2hB MOCS2 protein_coding protein_coding 44.74663 40.31003 56.5624 3.538236 2.987445 0.4886017 25.730427 24.215737 30.103126 2.2278744 1.1123075 0.3138519 0.57548750 0.60033333 0.53330000 -0.06703333 0.02780928 0.02707233 TRUE  
ENST00000527216 ENSG00000164172 HEK293_OSMI2_2hA HEK293_TMG_2hB MOCS2 protein_coding protein_coding 44.74663 40.31003 56.5624 3.538236 2.987445 0.4886017 3.050465 2.628182 3.859819 0.1505545 0.9366419 0.5527222 0.06848333 0.06653333 0.06683333 0.00030000 1.00000000 0.02707233 FALSE  
ENST00000584946 ENSG00000164172 HEK293_OSMI2_2hA HEK293_TMG_2hB MOCS2 protein_coding protein_coding 44.74663 40.31003 56.5624 3.538236 2.987445 0.4886017 11.302742 9.353396 15.681896 1.0328315 0.5559390 0.7449159 0.25387500 0.23116667 0.27946667 0.04830000 0.37168295 0.02707233    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164172 E001 92.6047747 0.0003024795 6.041416e-45 2.812108e-42 5 53095679 53098066 2388 - 2.167 1.603 -1.900
ENSG00000164172 E002 1.3455385 0.4372717319 6.844977e-01 7.874520e-01 5 53098067 53098070 4 - 0.338 0.391 0.309
ENSG00000164172 E003 13.1520037 0.0027688684 1.107122e-03 4.327054e-03 5 53098071 53098098 28 - 0.963 1.281 1.145
ENSG00000164172 E004 305.6071993 0.0011766709 1.371648e-16 5.801622e-15 5 53098099 53098383 285 - 2.374 2.587 0.710
ENSG00000164172 E005 407.8290344 0.0020617905 9.451981e-04 3.772250e-03 5 53098384 53098539 156 - 2.567 2.660 0.308
ENSG00000164172 E006 392.6747366 0.0010118719 2.861451e-01 4.265496e-01 5 53098540 53098667 128 - 2.584 2.615 0.101
ENSG00000164172 E007 0.4470576 0.0214578063 6.897596e-01 7.915960e-01 5 53098668 53098711 44 - 0.200 0.134 -0.693
ENSG00000164172 E008 223.0952950 0.0002590969 1.193657e-01 2.190400e-01 5 53100411 53100452 42 - 2.333 2.378 0.151
ENSG00000164172 E009 190.3183914 0.0003200498 7.969208e-01 8.704195e-01 5 53100453 53100487 35 - 2.277 2.292 0.048
ENSG00000164172 E010 189.8754639 0.0001876032 6.235461e-01 7.401146e-01 5 53100488 53100534 47 - 2.275 2.296 0.069
ENSG00000164172 E011 6.1527507 0.0027239586 2.188725e-01 3.490462e-01 5 53100535 53101125 591 - 0.776 0.935 0.613
ENSG00000164172 E012 2.3741155 0.0350747384 6.010441e-01 7.222022e-01 5 53101126 53101358 233 - 0.484 0.589 0.491
ENSG00000164172 E013 326.5139737 0.0019592281 1.877841e-01 3.109470e-01 5 53101359 53101509 151 - 2.532 2.499 -0.112
ENSG00000164172 E014 283.2628069 0.0025933299 1.412992e-01 2.498231e-01 5 53102097 53102224 128 - 2.475 2.431 -0.149
ENSG00000164172 E015 250.2869585 0.0011596486 3.112237e-02 7.414070e-02 5 53107077 53107221 145 - 2.427 2.374 -0.178
ENSG00000164172 E016 7.2347343 0.0058790469 3.130286e-04 1.432770e-03 5 53107222 53108097 876 - 1.083 0.629 -1.770
ENSG00000164172 E017 196.8835721 0.0009761275 1.524097e-04 7.576969e-04 5 53108522 53108643 122 - 2.345 2.243 -0.341
ENSG00000164172 E018 19.7543011 0.0250298009 8.051298e-01 8.760269e-01 5 53109251 53109711 461 - 1.326 1.295 -0.107
ENSG00000164172 E019 103.8228470 0.0004188006 6.684492e-04 2.783080e-03 5 53109712 53109777 66 - 2.074 1.962 -0.377
ENSG00000164172 E020 0.4386386 0.1139262765 7.107132e-01 8.078193e-01 5 53109985 53110063 79 - 0.200 0.133 -0.699