ENSG00000164171

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296585 ENSG00000164171 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA2 protein_coding protein_coding 1.871568 0.4515243 2.538784 0.05861536 0.0643461 2.465331 1.39921152 0.04352206 1.8309150 0.04352206 0.08961827 5.104145 0.5081333 0.08133333 0.7203333 0.6390000 5.172724e-07 5.172724e-07 FALSE TRUE
ENST00000503810 ENSG00000164171 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA2 protein_coding nonsense_mediated_decay 1.871568 0.4515243 2.538784 0.05861536 0.0643461 2.465331 0.34312654 0.19104242 0.7078687 0.14742275 0.02749138 1.836220 0.2661583 0.42400000 0.2796667 -0.1443333 9.840354e-01 5.172724e-07 FALSE TRUE
ENST00000509814 ENSG00000164171 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA2 protein_coding nonsense_mediated_decay 1.871568 0.4515243 2.538784 0.05861536 0.0643461 2.465331 0.03050171 0.00000000 0.0000000 0.00000000 0.00000000 0.000000 0.0681250 0.00000000 0.0000000 0.0000000   5.172724e-07 TRUE TRUE
ENST00000513685 ENSG00000164171 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA2 protein_coding nonsense_mediated_decay 1.871568 0.4515243 2.538784 0.05861536 0.0643461 2.465331 0.08659762 0.21695979 0.0000000 0.11767909 0.00000000 -4.504365 0.1361292 0.49466667 0.0000000 -0.4946667 4.645111e-02 5.172724e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164171 E001 1.914579 0.007740418 1.059476e-01 1.995392e-01 5 52989340 52989351 12 + 0.398 0.001 -9.067
ENSG00000164171 E002 5.473473 0.003079255 6.776092e-01 7.822837e-01 5 52989352 52989439 88 + 0.672 0.669 -0.014
ENSG00000164171 E003 6.519757 0.003214066 7.257676e-01 8.189684e-01 5 52989440 52989532 93 + 0.732 0.747 0.061
ENSG00000164171 E004 6.541883 0.002547692 8.914691e-03 2.606850e-02 5 53026748 53026868 121 + 0.776 0.282 -2.440
ENSG00000164171 E005 7.952157 0.002036723 1.696987e-02 4.487000e-02 5 53042112 53042221 110 + 0.839 0.452 -1.686
ENSG00000164171 E006 8.261531 0.002097012 1.334630e-02 3.672621e-02 5 53045001 53045092 92 + 0.853 0.452 -1.741
ENSG00000164171 E007 7.732786 0.002119628 2.106526e-01 3.393149e-01 5 53048363 53048477 115 + 0.808 0.669 -0.568
ENSG00000164171 E008 7.245974 0.002282218 1.090679e-01 2.041697e-01 5 53048643 53048770 128 + 0.793 0.574 -0.920
ENSG00000164171 E009 6.936728 0.002514664 1.328515e-01 2.380725e-01 5 53051411 53051559 149 + 0.776 0.574 -0.855
ENSG00000164171 E010 9.134654 0.001933202 2.179583e-01 3.479674e-01 5 53055538 53055688 151 + 0.867 0.747 -0.473
ENSG00000164171 E011 10.518892 0.001753515 1.028295e-01 1.947962e-01 5 53055984 53056149 166 + 0.924 0.747 -0.691
ENSG00000164171 E012 9.007452 0.002172741 1.028214e-01 1.947901e-01 5 53058025 53058101 77 + 0.867 0.669 -0.794
ENSG00000164171 E013 14.857517 0.116061624 7.445882e-01 8.328674e-01 5 53059874 53060012 139 + 1.030 1.095 0.236
ENSG00000164171 E014 12.875637 0.033120301 8.112355e-01 8.802056e-01 5 53060901 53061046 146 + 0.964 1.084 0.441
ENSG00000164171 E015 15.599643 0.003709978 7.383438e-02 1.496459e-01 5 53062786 53062929 144 + 1.078 0.921 -0.582
ENSG00000164171 E016 16.993358 0.001103045 3.064508e-02 7.322374e-02 5 53064912 53065115 204 + 1.119 0.921 -0.728
ENSG00000164171 E017 0.000000       5 53065800 53065840 41 +      
ENSG00000164171 E018 10.450342 0.001643100 6.504767e-01 7.615164e-01 5 53065841 53065977 137 + 0.906 0.921 0.056
ENSG00000164171 E019 10.036811 0.003266084 2.606188e-01 3.981762e-01 5 53067118 53067257 140 + 0.906 0.813 -0.360
ENSG00000164171 E020 9.502194 0.001735404 5.639143e-04 2.398776e-03 5 53070109 53070260 152 + 0.918 0.282 -2.991
ENSG00000164171 E021 10.123364 0.002418235 4.621602e-01 6.020418e-01 5 53071938 53072048 111 + 0.900 0.870 -0.113
ENSG00000164171 E022 7.677954 0.017721614 7.557862e-01 8.410217e-01 5 53072613 53072695 83 + 0.792 0.812 0.078
ENSG00000164171 E023 11.891521 0.019097917 8.552898e-01 9.105330e-01 5 53073118 53073259 142 + 0.942 1.045 0.381
ENSG00000164171 E024 10.260712 0.001837139 1.123792e-01 2.090114e-01 5 53074385 53074477 93 + 0.918 0.747 -0.669
ENSG00000164171 E025 8.614342 0.001959627 5.078098e-01 6.432447e-01 5 53075061 53075137 77 + 0.839 0.813 -0.101
ENSG00000164171 E026 10.744866 0.026367897 5.960865e-01 7.180716e-01 5 53075221 53075304 84 + 0.918 0.921 0.010
ENSG00000164171 E027 13.198808 0.001408886 8.296247e-01 8.930312e-01 5 53078772 53078874 103 + 0.991 1.044 0.198
ENSG00000164171 E028 15.143803 0.025018246 6.905662e-01 7.922396e-01 5 53080511 53080621 111 + 1.048 1.079 0.112
ENSG00000164171 E029 13.826078 0.014599260 1.886256e-01 3.120077e-01 5 53081592 53081696 105 + 1.030 0.920 -0.410
ENSG00000164171 E030 12.845908 0.011216435 4.454547e-01 5.869919e-01 5 53083340 53083453 114 + 0.991 0.966 -0.093
ENSG00000164171 E031 10.329840 0.005596207 4.171994e-02 9.422649e-02 5 53086952 53087041 90 + 0.930 0.669 -1.037
ENSG00000164171 E032 12.449289 0.002905682 8.050601e-02 1.603493e-01 5 53089946 53090062 117 + 0.991 0.813 -0.676
ENSG00000164171 E033 148.199179 0.011738075 6.427334e-12 1.380074e-10 5 53090519 53094779 4261 + 1.930 2.312 1.278